Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats

Zhang, Kevin J.; Ramdev, Rajan A.; Tuta, Nicholas J.; Spritzer, Mark D.

doi:10.1016/j.psyneuen.2020.104850

Cited by 9 publications

(3 citation statements)

References 66 publications

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“…8 Castrated male rats given lower doses of testosterone (0.125 mg per rat) perform better on a response task in a plus-maze, whereas those given higher doses of testosterone (0.500 mg per rat) perform better on a place task. 9 These findings suggest that testosterone promotes the use of place memory and learning in a dose-dependent manner.…”

Section: Gonadal Hormones and Memory Biasmentioning

confidence: 90%

“…In a water maze task, castrated male rats administered lower doses of testosterone (0.125 mg per rat) are biased towards cued‐response memory compared to those administered higher doses of testosterone (0.500 mg per rat), which are biased towards place memory 8 . Castrated male rats given lower doses of testosterone (0.125 mg per rat) perform better on a response task in a plus‐maze, whereas those given higher doses of testosterone (0.500 mg per rat) perform better on a place task 9 . These findings suggest that testosterone promotes the use of place memory and learning in a dose‐dependent manner.…”

Section: Gonadal Hormones and Memory Biasmentioning

confidence: 96%

“…30,35 Allopregnanolone (50 μg kg À1 ) alters hippocampal BDNF protein levels in a time-dependent manner, initially decreasing within the first 30 min after systemic administration, then significantly increasing after 3 h. 36 In male rats, administration of lower levels of testosterone (0.125 mg per rat) is associated with increased BDNF in the striatum, whereas higher levels of testosterone (0.500 mg per rat) is associated with increased BDNF in the hippocampus, corresponding to their bias toward striatum-dependent response memory or hippocampusdependent place memory respectively. 9 Although neither dendritic spine density, nor BDNF can account for the rapid effects of gonadal hormones on memory bias, they do offer potential mechanisms for the changes in memory bias seen throughout the estrous cycle. BDNF acts on multiple signaling pathways, but of particular importance to synaptic plasticity is the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway.…”

Section: Potential Cellular Mechanismsmentioning

confidence: 99%

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The role of progesterone in memory bias during spatial navigation in females

Gomez‐Perales

Brake

2022

J Neuroendocrinology

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Rats can use several memory systems to navigate a maze toward a reward. Two of these are place memory and response memory and female rats can be biased to predominantly use one over another. Both progesterone and estrogens have been shown to alter memory bias. Although the effects of estrogens have been well documented, the effects of progesterone remain somewhat unexplored. Mechanisms through which progesterone may be acting to exert its effects are reviewed here. Converging evidence suggests that the actions of progesterone differ depending on the presence of estrogens, frequently acting in opposition to estrogens when administered together. The hippocampus, dorsal striatum, and prefrontal cortex are likely involved, as is the progesterone metabolite, allopregnanolone. There is a need for more research on progesterone and memory bias, especially considering current formulations of hormonal contraceptives include progestins.

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Section: Gonadal Hormones and Memory Biasmentioning

confidence: 90%

Section: Gonadal Hormones and Memory Biasmentioning

confidence: 96%