Dose-Dependent Effects of Transdermal Nicotine on Early Morning Awakening and Rapid Eye Movement Sleep Time in Nonsmoking Normal Volunteers

Jc, Gillin; Lardon, M; Ruiz, Caroline; Golshan, Shahrokh; Salín-Pascual, Rafael J.

doi:10.1097/00004714-199408000-00006

Cited by 65 publications

(29 citation statements)

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“…Both exposure to nicotine and withdrawal from nicotine have been shown to have adverse effects on sleep quality (53,54). Nonsmoking individuals who are exposed to nicotine have increases in earlier awakening and decreased rapid eye movement sleep (55). Our findings suggest that the role of tobacco cessation in sleep among those who undergo dialysis merits study, although our results cannot establish causality or reversibility.…”

Section: Discussionmentioning

confidence: 55%

Sleep Quality and Its Correlates in the First Year of Dialysis

Unruh

Buysse

Dew

et al. 2006

Clinical Journal of the American Society of Nephrology

106

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Although sleep problems are thought to be prevalent among patients who undergo dialysis, there is only limited information on the determinants of sleep quality and the change in sleep quality during the first year of dialysis treatment. This report uses data from a national cohort study of incident hemodialysis and peritoneal dialysis patients to identify the correlates of sleep quality and to determine the extent to which sleep quality is related to patients' health-related quality of life and survival. This report includes 909 incident dialysis patients who responded to questions about sleep quality. Three quarters of incident dialysis patients reported impaired sleep, and 14% had a decline in sleep quality in the first year of treatment. Poor sleep quality was significantly related to black race, higher serum phosphate, current smoking, benzodiazepine prescription, and complaints of severe restless legs. Poor baseline sleep quality was associated with lower SF-36 physical and mental component summary scores, vitality scores, and bodily pain scores (all P < 0.001). Younger age, current smoking, and benzodiazepine prescription were associated with decreases in sleep quality at 1 yr. There was no association between baseline sleep quality and survival; however, a decline in sleep quality during the first year on dialysis was associated with shorter survival (hazard ratio 1.44; 95% confidence interval 1.13 to 1.83; P ‫؍‬ 0.003). Future work should examine the link between sleep quality and daytime functioning in the kidney failure population and the extent to which improving sleep quality will improve dialysis patient outcomes.

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Section: Discussionmentioning

confidence: 55%

Sleep Quality and Its Correlates in the First Year of Dialysis

Unruh

Buysse

Dew

et al. 2006

Clinical Journal of the American Society of Nephrology

106

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“…Polysomnography findings between different studies examining nicotine withdrawal have been inconsistent, likely reflecting differences in the degree of nicotine dependence of participants and differences in psychometric tools used (Jaehne et al, 2009). Studies assessing sleep in non-smokers have demonstrated acute changes in sleep architecture, chiefly dose-dependent reductions in REM, followed by REM rebound in subsequent sleep episodes (Gillin et al, 1994).…”

Section: Sleep Studiesmentioning

confidence: 99%

Commonly used stimulants: Sleep problems, dependence and psychological distress

Ogeil¹,

Phillips²

2015

Drug and Alcohol Dependence

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“…A small number of studies did not use change scores; instead, a placebo postdose mean (and standard deviation) was reported as were postdose means (and standard deviations) for active doses (e.g., Gillin, Lardon, Ruiz, Golshan, & Salin-Pascual, 1994;Kumari, Cotter, Checkley, & Gray, 1997). Effect sizes for these studies are not directly comparable with the effect sizes from the within-subjects designs because of the lack of predose means and standard deviations.…”

Section: Studies Included In Reviewmentioning

confidence: 99%

Does nicotine do what we think it does? A meta‐analytic review of the subjective effects of nicotine in nasal spray and intravenous studies with smokers and nonsmokers

Kalman

Smith

2005

Nicotine & Tobacco Research

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We conducted a meta-analysis of placebo-controlled laboratory studies of the subjective effects of nicotine. A total of 15 studies (11 with nasal spray, four with intravenous administration) with smokers and six studies (all with nasal spray) with never-smokers were included. Studies of other routes of administration (e.g., smoked tobacco) were not included because of insufficient numbers of available effect sizes. Meta-analysis results indicated that nicotine increased vigor for smokers but increased fatigue for never-smokers. Nicotine increased head rush for both smokers and never-smokers. In studies of smokers only, nicotine also increased ratings of drug high and drug liking. Contrary to expectations, nicotine decreased relaxation and increased tension/jitteriness for both smokers and never-smokers. Dose-response relationships were most clearly observed for head rush and drug high. Considerable variability was found across studies for a given nicotine dose and route of administration. Implications of the current findings about the role of subjective effects in nicotine reinforcement and self-administration are discussed along with commentary on methodological issues and recommendations for future studies.

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Dose-Dependent Effects of Transdermal Nicotine on Early Morning Awakening and Rapid Eye Movement Sleep Time in Nonsmoking Normal Volunteers

Cited by 65 publications

References 0 publications

Sleep Quality and Its Correlates in the First Year of Dialysis

Sleep Quality and Its Correlates in the First Year of Dialysis

Commonly used stimulants: Sleep problems, dependence and psychological distress

Does nicotine do what we think it does? A meta‐analytic review of the subjective effects of nicotine in nasal spray and intravenous studies with smokers and nonsmokers

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