Dose-dependent effects of xylooligosaccharides on glycemic regulation with L. rhamnosus CCFM1060 in diabetic mice

Abstract

Dietary intervention with L. rhamnosus CCFM1060 combined with different doses of XOS affected HFD- and STZ-induced diabetic metabolic disorders in a dose-dependent manner.

Xylooligosaccharides ameliorate insulin resistance by increasing Akkermansia muciniphila and improving intestinal barrier dysfunction in gestational diabetes mellitus mice

“…All these factors contribute to the varieties in the experimental results from different labs. Interestingly, a more recent study from Cui et al (2023) 28 showed that L. rhamnosus CCFM1060 combined with different doses of XOS exerted dose-dependent effects on glucose metabolism in diabetic mice. L. rhamnosus CCFM1060 (5 × 10 9 CFU mL L −1 ) combined with a low dose (250 mg kg −1 ) of XOS could alleviate diabetes symptoms and increase SCFA-producing bacteria.…”

“…), although they increased Bifidobacterium. 28 It is currently for sure that XOS intervention can affect the diversity and abundance of the gut microbiota. However, it is far from a complete understanding of how many beneficial bacteria can be selectively proliferated by XOS intervention, especially in human populations with a healthy status as well as various pathological statuses.…”