Dose-dependent pulmonary response of well-dispersed titanium dioxide nanoparticles following intratracheal instillation

Oyabu, Takako; Morimoto, Yasuo; Hirohashi, Masami; Horie, Masanori; Kambara, Tatsunori; Lee, Byeong Woo; Hashiba, Masayoshi; Mizuguchi, Yohei; Myojo, Toshihiko; Kuroda, Etsushi

doi:10.1007/s11051-013-1600-y

Cited by 41 publications

(46 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Instillation studies have the problem that the lung burden with a large quantity of particles—albeit with low toxicity—can result in an excessive dose to macrophages, which would induce impaired clearance, accumulation of lung burden, and pathological changes [18,27,33,34]. In this study, the maximum dose of instilled nanoparticles we chose was 1 mg.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the amount of TiO 2 in the lung at 3 days after inhalation at the high concentration and that after the 0.36 mg instillation were almost the same. Although a single high dose of particles is known to induce delayed clearance due to the bolus effect [27,37], instillation studies result in almost the same BHT as in inhalation studies, probably because the nanoparticles are distributed evenly after instillation, causing a minimum bolus effect. Alternatively, the bolus effect after the intratracheal instillation might have been similar to the effect caused during the 4-week inhalation periods.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the investigation about whether the biopersistence is also available for evaluating the toxicity of nanoparticles is important and meaningful. Although we have reported the biopersistence of nanomaterials in inhalation and instillation [24,25,26,27] and there are some recent reports of nanomaterials [28,29,30,31,32], there is no report which verifies the usefulness or availability of biopersistence for evaluating the toxicity of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biopersistence of NiO and TiO2 Nanoparticles Following Intratracheal Instillation and Inhalation

Oyabu

Myojo

Lee

et al. 2017

IJMS

Self Cite

View full text Add to dashboard Cite

The hazards of various types of nanoparticles with high functionality have not been fully assessed. We investigated the usefulness of biopersistence as a hazard indicator of nanoparticles by performing inhalation and intratracheal instillation studies and comparing the biopersistence of two nanoparticles with different toxicities: NiO and TiO2 nanoparticles with high and low toxicity among nanoparticles, respectively. In the 4-week inhalation studies, the average exposure concentrations were 0.32 and 1.65 mg/m3 for NiO, and 0.50 and 1.84 mg/m3 for TiO2. In the instillation studies, 0.2 and 1.0 mg of NiO nanoparticles and 0.2, 0.36, and 1.0 mg of TiO2 were dispersed in 0.4 mL water and instilled to rats. After the exposure, the lung burden in each of five rats was determined by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES) from 3 days to 3 months for inhalation studies and to 6 months for instillation studies. In both the inhalation and instillation studies, NiO nanoparticles persisted for longer in the lung compared with TiO2 nanoparticles, and the calculated biological half times (BHTs) of the NiO nanoparticles was longer than that of the TiO2 nanoparticles. Biopersistence also correlated with histopathological changes, inflammatory response, and other biomarkers in bronchoalveolar lavage fluid (BALF) after the exposure to nanoparticles. These results suggested that the biopersistence is a good indicator of the hazards of nanoparticles.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biopersistence of NiO and TiO2 Nanoparticles Following Intratracheal Instillation and Inhalation

Oyabu

Myojo

Lee

et al. 2017

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…43 Still, nanoparticles can cause damage to higher organisms, especially when inhaled. [44][45][46] This is a common trait of nanoparticles and their interaction with the delicate and absorption-oriented cells of the pulmonary organs. The adverse effects are not necessarily related to the chemical reactivity and can occur with nonreactive particles such as silica particles.…”

Section: Nanoparticles As Uv Absorbers and Their Ecological And Toxicmentioning

confidence: 99%

Nanoparticulate inorganic UV absorbers: a review

2015

View full text Add to dashboard Cite

Inorganic nanoparticles with UV-absorbing properties are an important class of UV filters. They can be used in various applications and in a variety of forms, including suspensions, nanocomposites, and solid thin films. In this review, an overview of the synthetic methods and their respective products is given for the most popular UV-absorbing nanomaterials, including zinc oxide, titanium dioxide, cerium dioxide and ferrous oxides, and oxyhydroxides.

show abstract

“…The mass of TiO 2 retained in each lung was calculated from the determined Ti amounts divided by the Ti content (59.9 %) of the TiO 2 [4].…”

Section: Determination Of Tio 2 In Lungsmentioning

confidence: 99%

Comparison between whole-body inhalation and nose-only inhalation on the deposition and health effects of nanoparticles

Oyabu

Morimoto

Izumi

et al. 2015

Environ Health Prev Med

Self Cite

View full text Add to dashboard Cite

show abstract

Dose-dependent pulmonary response of well-dispersed titanium dioxide nanoparticles following intratracheal instillation

Cited by 41 publications

References 17 publications

Biopersistence of NiO and TiO2 Nanoparticles Following Intratracheal Instillation and Inhalation

Biopersistence of NiO and TiO2 Nanoparticles Following Intratracheal Instillation and Inhalation

Nanoparticulate inorganic UV absorbers: a review

Comparison between whole-body inhalation and nose-only inhalation on the deposition and health effects of nanoparticles

Contact Info

Product

Resources

About