Dose‐dependent reduction in renal magnesium clearance by amiloride during frusemide‐induced diuresis in rats

Abstract

1The effects of the potassium-sparing diuretic, amiloride, on fractional magnesium excretion were investigated at four doses (0.02, 0.08, 0.20 and 2.00mgkg1lh-1) during frusemide-induced diuresis. 2 Amiloride caused a dose-dependent reduction in the fractional excretion of both magnesium and potassium, whereas the effects of amiloride, over the same dose range, on fractional sodium and calcium excretion were not dose-dependent. 3 The results indicate that amiloride exerted a specific renal action to alter magnesium and potassium transport dissociated from effects on sodium excretion.

Tissue Electrolyte Changes Induced by High Doses of Diuretics in Rats

“…In relation to the second objective of the present study it was found that the addition of amiloride increased potassium in plasma and skeletal muscle and enhanced magnesium in all examined tissues compared to the furosemide group and also partly to the control group. This is in good correspondence with both acute renal studies (Devane & Ryan 1983) and a clinical study on electrolyte content in lymphocytes showing that the addition of amiloride to furosemide administration compensates for mag-nesium and potassium losses. In the present study the renal magnesium and potassium sparing effects of amiloride have probably overcorrected for the renal effects of furosemide.…”

“…The first aim of the present study was to investigate whether the long term administration of the loop blocking diuretic furosemide might result in myocardial losses of magnesium and potassium as well as in electrolyte disturbances of plasma, skeletal muscle and bone. The second aim of the study was to investigate if the diuretic amiloride, known to correct for furosemide-induced losses of magnesium and potassium in acute renal clearance studies in the rat (Devane & Ryan 1983) might prevent potential electrolyte disturbances induced by furosemide also in a chronic experiment.…”

Diuretics

“…Amiloride impairs urinary acidification (GUIGNARD and PETERS 1970). Amiloride also reduces urinary Mgz+ (DEVANE and RYAN 1983) and Ca z + (COSTANZO and WEINER 1976) excretion. Amiloride also reduces urinary Mgz+ (DEVANE and RYAN 1983) and Ca z + (COSTANZO and WEINER 1976) excretion.…”

“…The use of amiloride in combination with other diuretics, such as furosemide, prevents diuretic-induced Mg2+ wasting (DEVANE and RYAN 1983;. The use of amiloride in combination with other diuretics, such as furosemide, prevents diuretic-induced Mg2+ wasting (DEVANE and RYAN 1983;.…”

Direct Effects of Furosemide and Amiloride on the Perfused and Ischaemic Rat Heart

“…The addition of amiloride to rats receiving furosemide for four weeks increased myocardial tolerance to ischaemia . The most likely explanation was related to the opposing effects of furosemide and amiloride upon the renal handling of magnesium and potassium (Devane & Ryan 1983) and thus to the normalization of a low serum magnesium (and potassium) known to reduce myocardial tolerance to ischaemia (Borchgrevink & Jynge 1987b). However, a primary myocardial effect of furosemide with some protection by the addition of amiloride could not be neglected.…”