Dose-dependent response of intramuscular fat accumulation in longissimus dorsi muscle of finishing pigs to dietary lysine levels

Effects of dietary lysine levels and lighting conditions on intramuscular fat accumulation in growing pigs

“…We previously reported that dietary low lysine promotes accumulation of intramuscular fat (IMF) in porcine muscle (Katsumata, Kobayashi, Matsumoto, Tsuneishi, & Kaji, 2005; Katsumata, Kyoya, Ishida, Ohtsuka, & Nakashima, 2012; Kobayashi, Ishida, Ashihara, Nakashima, & Katsumata, 2012). We subjected the pigs to ad libitum feeding in these experiments to allow them to obtain sufficient energy for IMF accumulation.…”

Research Article Expression of lipid metabolism and myosin heavy chain genes in pigs is affected by genotype and dietary lysine

“…A previous study reported that the content of carnitine in the Logissimus muscle was lower in pigs fed with low dietary lysine contents, promoting increase of IMF. Carnitine plays a pivotal role in β-oxidation of fatty acids by transporting fatty acyl-CoA across the inner mitochondrial membrane (Katsumata et al, 2012). Therefore, in the present study the reduced content of lysine decreased the expression of MyHC IIa in the Logissimus muscle of gilts, which may have led to a decrease of β-oxidation contributing to a higher intramuscular fat content.…”

“…The oxidative fibers may be associated to increased IMF content (Guo et al, 2011). Furthermore, low dietary lysine content decreases the transcription of fibers IIB, but there is no available report showing the mechanism by which lysine causes this effect (Morales et al, 2015) and increased IMF content (Katsumata et al, 2012;Madeira et al, 2013).…”

“…Fat accretion may be affected by dietary lysine content because lysine plays a pivotal role in regulating energy metabolism in the skeletal muscle without compromise growth rate of pigs (Katsumata, 2011;Katsumata et al, 2012). The extent of fat deposition in skeletal muscles varies according to the balance between triglycerides synthesis, fat mobilization, fatty acid transport as well as fatty acid oxidation (Zhao et al, 2009).…”

Effects of Dietary Low Level of Threonine and Lysine on the Accumulation of Intramuscular Fat in Porcine Muscle

“…We have been conducting a series of experiments on nutritional regulation of IMF in porcine muscle and have found that a shortage of a single amino acid lysine in the diet enhanced the IMF contents of longissimus dorsi muscle of pigs. [2][3][4] Since a reduction in dietary protein also enhanced the IMF contents of porcine muscle, [5][6][7] this effect of shortage of lysine allowed us to hypothesize that shortages of other indispensable amino acids enhance IMF contents in porcine muscle.…”