Dose-dependent responses of metabolism and tissue injuries in clam Ruditapes philippinarum after subchronic exposure to cadmium

Zhan, Junfei; Wang, Shuang; Li, Fēi; Ji, Chenglong; Wu, Huifeng

doi:10.1016/j.scitotenv.2021.146479

Cited by 39 publications

(8 citation statements)

References 49 publications

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“…Instead, this type of response may be more specific to alterations in the endocrine system, for which there are many examples of larger effects at low and nontoxic concentrations. 53 Nonmonotonic responses have also been reported in other invertebrate species exposed to chemical pollutants such as in the clam Ruditapes phillipanarum exposed to cadmium whereby enzyme activity shows a nonmonotonic response, 56 and in Daphnia magna exposed to the biopesticide Bacillus thuringiensis whereby survival and immobilization have a nonmonotonic response. 57 In conclusion, using L. stagnalis as a model mollusc, our findings indicate that similarly to field derived correlational analyses, pollutants may rank highest for potential to cause harm to FW molluscs with effects observed at our lowest test level which is below the concentrations detected in the environment.…”

Section: ■ Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Laboratory-Based Comparison for the Effects of Environmental Stressors Supports Field Evidence for the Relative Importance of Pollution on Life History and Behavior of the Pond Snail, Lymnaea stagnalis

Moore

Alexander

Sloman

et al. 2021

Environ. Sci. Technol.

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Biodiversity is declining at an alarming rate globally, with freshwater ecosystems particularly threatened. Field-based correlational studies have "ranked" stressors according to their relative effects on freshwater biota, however, supporting cause-effect data from laboratory exposures are lacking. Here, we designed exposures to elicit chronic effects over equivalent exposure ranges for three ubiquitous stressors (temperature: 22−28 °C; pollution [14 component mixture]: 0.05−50 μg/L; invasive predator cue [signal crayfish, Pacifasticus leniusculus]: 25−100% cue) and investigated effects on physiological end points in the pond snail (Lymnaea stagnalis). All stressors reduced posthatch survival at their highest exposure levels, however, highly divergent effects were observed at lower test levels. Temperature stimulated hatching, growth, and reproduction, whereas pollution delayed hatching, decreased growth, reduced egg number/embryo viability, and induced avoidance behavior. The invasive predator cue stimulated growth and reduced embryo viability. In agreement with field-based ranking of stressors, pollution was identified as having the most severe effects in our test system. We demonstrate here the utility of laboratory studies to effectively determine hierarchy of stressors according to their likelihood of causing harm in the field, which has importance for conservation. Finally, we report negative impacts on life-history traits central to population stability (survival/reproduction) at the lowest pollution level tested (0.05 μg/L).

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Section: ■ Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Laboratory-Based Comparison for the Effects of Environmental Stressors Supports Field Evidence for the Relative Importance of Pollution on Life History and Behavior of the Pond Snail, Lymnaea stagnalis

Moore

Alexander

Sloman

et al. 2021

Environ. Sci. Technol.

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“…28,29 CSs are known to respond to abiotic stress. 30,31 For example, a combination of transcriptomic and proteomic data indicated that CS is a key detoxification enzyme for aluminum toxicity in a tolerant maize line. 32 In our study, under 0.45 μM ISA exposure, each of the three OECS4 lines (OECS4-4, 8, 11) showed weak growth compared to WT (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…CS catalyzes the first committed step of the TCA cycle, which is the reaction of oxaloacetate with acetyl coenzyme A (acetyl‐CoA) to produce citrate 28,29 . CSs are known to respond to abiotic stress 30,31 . For example, a combination of transcriptomic and proteomic data indicated that CS is a key detoxification enzyme for aluminum toxicity in a tolerant maize line 32 .…”

Section: Discussionmentioning

confidence: 99%

Multi‐omics analysis identifies EcCS4 is negatively regulated in response to phytotoxin isovaleric acid stress in Echinochloa crus‐galli

Li,

Bai,

Bai

et al. 2023

Pest Management Science

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BACKGROUNDKnowledge of herbicidal targets is critical for weed management and food safety. The phytotoxin isovaleric acid (ISA) is effective against weeds with a broad spectrum, carries low environmental risks, and is thus an excellent herbicide lead. However, the biochemical and molecular mechanisms underlying the action of ISA remain unclear.RESULTSMulti‐omics data showed that acetyl coenzyme A (acetyl‐CoA) was the key affected metabolite, and that citrate synthase (CS) 4 was substantially down‐regulated under ISA treatment in Echinochloa crus‐galli leaves. In particular, the transcript level of EcCS4 was the most significantly regulated among the six genes involved in the top 10 different pathways. The EcCS4 encodes a protein of 472 amino acids and is localized to the cell membrane and mitochondria, similar to the CS4s of other plants. The protein content of EcCS4 was down‐regulated after ISA treatment at 0.5 h. ISA markedly inhibited the CS4 activity in vitro in a concentration‐dependent manner (IC50 = 41.35 μM). In addition, the transgenic rice plants overexpressing EcCS4 (IC50 = 111.8 mM for OECS4‐8 line) were more sensitive, whereas loss‐of‐function rice mutant lines (IC50 = 746.5 mM for oscs4‐19) were more resistant to ISA, compared to wild type (WT) plants (IC50 = 355.6 mM).CONCLUSIONCS4 was first reported as a negative regulator of plant responses to ISA. These results highlight that CS4 is a candidate target gene for the development of novel herbicides and for breeding herbicide‐resistant crops. © 2023 Society of Chemical Industry.

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“…A further survey of the literature for the purpose of this study revealed ample evidence suggestive of hormesis for numerous aquatic organisms and various pollutants and emerging contaminants in dozens of publications, of which only a few selected examples are cited here (older examples can also be traced in the therein references). These examples include a plethora of species, such as of algae (microphytes) [38][39][40][41][42][43][44][45][46][47][48][49] , aquatic flowering plants [50] , organism-attached biofilms [51] , crustaceans [52][53][54][55][56][57] , cyanobacteria [49,[58][59][60][61] , fishes [62][63][64][65][66][67][68][69] , macrophytes [70][71][72][73][74][75] , marine polychaete [76] , mollusks (e.g., clams and mussels) [77,78] , periphyton [79] , phytoplankton [80] , sea anemones [81,82] , and snails [83] . Responses suggestive of hormesis were found for molecular (molecules...…”

mentioning

confidence: 99%

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

Agathokleous¹,

Barceló²,

Fatta‐Kassinos³

et al. 2021

WECN

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Contaminants of emerging concern are widespread in the world’s waters, raising concerns regarding their effects on living organisms. To evaluate the effects of and predict risks associated with such chemicals, dose-response studies are needed, while the nature of the dose-response relationship is critical for the outcomes of such evaluations. Here, we summarize the literature reporting hormetic responses of aquatic organisms to contaminants of emerging concern. Hormesis is a biphasic dose response encompassing stimulatory responses to low doses and inhibitory responses to high doses. We demonstrate that it occurs widely in numerous aquatic organisms exposed to a wide array of contaminants, including nano/microplastics, suggesting potential effects at doses/concentrations that are considerably lower than the traditional toxicological threshold, which cannot be identified or predicted unless hormesis is considered in the study design. To tackle the effects and associated risks of nano/microplastics and other contaminants on aquatic organisms, hormesis should therefore be taken into account early in the design of studies as well as in relevant risk assessments.

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Dose-dependent responses of metabolism and tissue injuries in clam Ruditapes philippinarum after subchronic exposure to cadmium

Cited by 39 publications

References 49 publications

Laboratory-Based Comparison for the Effects of Environmental Stressors Supports Field Evidence for the Relative Importance of Pollution on Life History and Behavior of the Pond Snail, Lymnaea stagnalis

Laboratory-Based Comparison for the Effects of Environmental Stressors Supports Field Evidence for the Relative Importance of Pollution on Life History and Behavior of the Pond Snail, Lymnaea stagnalis

Multi‐omics analysis identifies EcCS4 is negatively regulated in response to phytotoxin isovaleric acid stress in Echinochloa crus‐galli

Contaminants of emerging concern and aquatic organisms: the need to consider hormetic responses in effect evaluations

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