Dose distribution outside of a sphere of P-32 chromic phosphorous colloid

Hechtman, Charles D.; Li, Zuofeng; Mansur, David B.; Perez, Carlos A.; Myerson, Robert J.; Simpson, Joseph R.; Anders, Jon C.; Wu, Catherine S.; Palucci, Cindy A.

doi:10.1016/j.ijrobp.2004.12.071

Cited by 11 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The optimal prescribed dose to the cyst wall is 200–300 Gy (Hechtman et al, 2005; Sadeghi et al, 2007) up to 400 Gy with significant increased risks especially to the optic apparatus once doses surpass 400 Gy (Derrey et al, 2008; Floyd et al, 2009). There is evidence that cyst volumes exceeding 100 ml will not respond well (Albright et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

Bartels¹,

Laperrière²,

Bouffet³

et al. 2012

Front. Endocrin.

View full text Add to dashboard Cite

Introduction: Craniopharyngioma of childhood are commonly cystic in nature. An intracystic catheter insertion and subsequent instillation of substances inducing cyst shrinkage seems a beneficial strategy avoiding additional morbidity in a highly vulnerable brain location. Methods: A systematic review of the medical literature was performed to identify potentially relevant, all languages articles using Ovid MEDLINE and EMBASE from inception to July 2011 and Cochrane Central Register of Controlled Trials to third quarter 2011. All references were examined for relevancy. Results: Of 142 unique references, 71 referred to substances used for intracystic craniopharyngioma treatment. General aspects of intracystic catheter insertion as well as response rates, risks, and outcomes of children treated with intracystic radioisotopes, bleomycin, and interferon (IFN) are critically reviewed and an outline for potential future endeavors provided. Conclusion: IFN seems currently the intracystic substance with the best benefit risk ratio. The authors advocate for consensus on prospective data collection and standardized intracystic treatment strategies to allow reliable comparisons and herewith optimize treatment and outcome.

show abstract

Section: Resultsmentioning

confidence: 99%

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

Bartels¹,

Laperrière²,

Bouffet³

et al. 2012

Front. Endocrin.

View full text Add to dashboard Cite

show abstract

“…Dosimetry is standardized, and can be adjusted for cyst volume. The optimal prescribed dose to the cyst wall is 200 -300 Gy [17,28,29] . Additionally, multiple instillations of 32 P are not required to achieve a therapeutic eff ect; therefore, it does not require the implantation of a reservoir.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroendoscopy allows for direct visualization of the tumor cyst, facilitating tumor cyst aspiration and injection of the 32 P colloid [24] . The viscous nature of the colloid enables easier handling and less chance for extravasation [28] . Using direct visualization, there is less chance for multiple cyst perforations and subsequent leaking of the radionucleotide.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic, Image-Guided, Transnasal Instillation of³²P for Recurrent Infrachiasmatic Cystic Craniopharyngioma

Floyd

Cmelak²,

Russell³

et al. 2009

Minim Invasive Neurosurg

View full text Add to dashboard Cite

show abstract

“…There is some evidence that the radiocolloid does not always remain uniformly distributed throughout the cyst volume, but partly accumulates on the cyst wall during the course of therapy (e.g. Young et al 1976, Balachandran et al 1985, Harbert 1987, Hechtman et al 2005. As a consequence, such accumulation leads to an increased dose reaching surrounding structures at risk, with a magnitude depending on the size of the cyst (Harbert 1987, Hechtman et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Voxel-based dose calculation in radiocolloid therapy of cystic craniopharyngiomas

Treuer

Hoevels²,

Luyken³

et al. 2015

Phys. Med. Biol.

View full text Add to dashboard Cite

Very high doses are administered in radiocolloid therapy of cystic craniopharyngiomas. However individual dose planning is not common yet mainly due to insufficient image resolution. Our aim was to investigate whether currently available high-resolution image data can be used for voxel-based dose calculation for short-ranged β-emitters ((32)P,(90)Y,(186)Re) and to assess the achievable accuracy. We developed a convolution algorithm based on voxelized dose activity distributions and dose-spread kernels. Results for targets with 5-40 mm diameter were compared with high-resolution Monte Carlo calculations in spherical phantoms. Voxel size was 0.35 mm. Homogeneous volume and surface activity distributions were used. Dose-volume histograms of targets and shell structures were compared and γ index (dose tolerance 5%, distance to agreement 0.35 mm) was calculated for dose profiles along the principal axes. For volumetric activity distributions 89.3% ± 11.9% of all points passed the γ test (mean γ 0.53 ± 0.16). For surface distributions 33.6% ± 14.8% of all points passed the γ test (mean γ 2.01 ± 0.60). The shift of curves in dose-volume histograms was -1.7 Gy ± 7.6 Gy (-4.4 Gy ± 24.1 Gy for (186)Re) in volumetric distributions and 46.3% ± 32.8% in surface distributions. The results show that individual dose planning for radiocolloid therapy of cystic craniopharyngiomas based on high-resolution voxelized image data is feasible and yields highly accurate results for volumetric activity distributions and reasonable dose estimates for surface distributions.

show abstract

Dose distribution outside of a sphere of P-32 chromic phosphorous colloid

Cited by 11 publications

References 17 publications

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

Endoscopic, Image-Guided, Transnasal Instillation of³²P for Recurrent Infrachiasmatic Cystic Craniopharyngioma

Voxel-based dose calculation in radiocolloid therapy of cystic craniopharyngiomas

Contact Info

Product

Resources

About

Dose distribution outside of a sphere of P-32 chromic phosphorous colloid

Cited by 11 publications

References 17 publications

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

Endoscopic, Image-Guided, Transnasal Instillation of32P for Recurrent Infrachiasmatic Cystic Craniopharyngioma

Voxel-based dose calculation in radiocolloid therapy of cystic craniopharyngiomas

Contact Info

Product

Resources

About

Endoscopic, Image-Guided, Transnasal Instillation of³²P for Recurrent Infrachiasmatic Cystic Craniopharyngioma