Dose Effects of Morphine and Butorphanol Alone and in Combination After Burn Injury in the Rat

Osgood, Patricia F.; Kazianis, A.; Kemp, James W.; Atchison, N.E.; Carr, D.B.; Szyfelbein, S.K.

doi:10.1097/00004630-199507000-00004

Cited by 9 publications

(3 citation statements)

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“…Butorphanol is more effective than morphine as an analgesic in burned rats, but the combination of morphine and butorphanol is less effective than butorphanol alone, both in duration and quality of analgesia. 8 The combination of oxymorphone, an OP3 agonist, and butorphanol has additive antinociceptive effects compared to the administration of each agent alone in cats. 9 Hydromorphone is a clinically useful analgesic in cats.…”

mentioning

confidence: 99%

Antinociceptive Effects of Hydromorphone, Butorphanol, or the Combination in Cats

Lascelles

Robertson

2004

Veterinary Internal Medicne

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The goal of this study was to assess the antinociceptive activity of a single dose of hydromorphone or butorphanol and to examine the effect of their coadministration on thermal thresholds in cats. Thermal thresholds were measured after IM administration of hydromorphone (0.1 mg/kg), butorphanol (0.4 mg/kg), a combination of butorphanol and hydromorphone (0.4 and 0.1 mg/kg), or saline to each of 6 cats in a randomized, blinded, crossover study design. There were at least 12 days between treatments. Thermal thresholds were measured by a thorax-mounted thermal threshold-testing device specifically developed for cats. Thermal thresholds were measured before treatment, at varying intervals to 12 hours, and at 24 hours after treatments. Data were analyzed by an analysis of variance with a repeat factor of time. Dysphoria was associated with butorphanol administration but not with hydromorphone or hydromorphone-butorphanol combined administration. Vomiting was seen with hydromorphone but not with butorphanol or hydromorphone-butorphanol combined. The control treatment group was stable over time (P = .22; mean threshold, 40.1 degrees C). Thresholds were significantly (P < .05) higher than the control treatment between 15 and 165 minutes for butorphanol, between 15 and 345 minutes for hydromorphone, and between 15 and 540 minutes for hydromorphone-butorphanol combined. The addition of butorphanol to hydromorphone decreased the intensity of antinociception during the 1st 2 hours but extended the duration of observable antinociception from 5.75 to 9 hours. The present study suggests that the combination of butorphanol and a pure OP3 (mu) receptor agonist clinically does not produce increased analgesia and indeed may result in decreased analgesia.

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confidence: 99%

Antinociceptive Effects of Hydromorphone, Butorphanol, or the Combination in Cats

Lascelles

Robertson

2004

Veterinary Internal Medicne

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“…In humans, the use of butorphanol as premedication did not change the interoperative fentanyl requirement for hysterectomy 34 and butorphanol has been reported to have a synergistic effect when used together with m-agonist in cats 35 and rats. 36 Butorphanol was also used in rabbits, 37 rats 38 and humans 39 to reverse the respiratory depression caused by fentanyl without compromising postoperative analgesia.…”

Section: Schö Ffmann Et Al Piglet Responses To Propofol/fentanyl Anamentioning

confidence: 99%

Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl

et al. 2009

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The purpose of the study was to assess the haemodynamic (blood pressure and heart rate) changes and stress responses (serum cortisol and serum amyloid A [SAA] concentrations) to surgery in piglets during total intravenous anaesthesia (TIVA) with propofol and fentanyl. After preanaesthetic medication with intramuscular midazolam (0.5 mg/kg body mass), ketamine (10 mg/kg) and butorphanol (0.5 mg/kg) anaesthesia was induced in five piglets, with intravenous propofol (1 mg/kg) followed by tracheal intubation and mechanical lung ventilation. Soft tissue surgery was performed in the jugular and inguinal regions during TIVA with propofol (8 mg/kg/h) and fentanyl (35 mg/kg/h). Anaesthesia was maintained for 300 min after surgery as the piglets were the control group of a project involving extracorporeal membrane oxygenation. Mean plasma cortisol concentration decreased significantly (P , 0.05) from 59 + 39.9 nmol/L (mean + 1 SD) before surgery to 7.5 + 2.5 nmol/L 300 min after end of surgical procedure. The mean SAA concentrations increased over the same period from 1.6 + 2.3 mg/mL to 4.2 + 5.6 mg/mL without statistical significance. The baseline ( presurgery) mean arterial pressure (MAP) was 72 + 9 mmHg compared with 72 + 11 mmHg 300 min after end of surgery. Neither heart rate nor lactate concentrations changed significantly over the same time points: heart rate was 104 + 11 and 103 + 15 beats/min whereas mean lactate concentrations were reduced from 1.14 + 0.45 mmol/L to 0.90 + 0.22 mmol/L. Haemodynamic stability, a decrease in serum cortisol and a non-statistically significant rise in mean SAA concentrations suggest that the anaesthetic described suppresses the stress response of piglets to surgery without adverse cardiovascular effects. Therefore, it may prove useful in cardiovascular research.

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“…Although comparative studies were performed between morphine and butorphanol [11,12], no investigations of the clinical antinociceptive effects of butorphanol combined with morphine PCA have been considered. The objective of this study was to evaluate the analgesic efficacy, morphine-sparing effect and side effects of butorphanol administered intravenously by a continuous basal infusion combined with intravenous morphine PCA after total abdominal hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

Continuous infusion of butorphanol combined with intravenous morphine patient-controlled analgesia after total abdominal hysterectomy: a randomized, double-blind controlled trial

Shen¹,

Liu²,

Xu³

et al. 2009

European Journal of Anaesthesiology

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Dose Effects of Morphine and Butorphanol Alone and in Combination After Burn Injury in the Rat

Cited by 9 publications

References 0 publications

Antinociceptive Effects of Hydromorphone, Butorphanol, or the Combination in Cats

Antinociceptive Effects of Hydromorphone, Butorphanol, or the Combination in Cats

Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl

Continuous infusion of butorphanol combined with intravenous morphine patient-controlled analgesia after total abdominal hysterectomy: a randomized, double-blind controlled trial

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