Dose-enhancement of MCF 7 cell line radiotherapy using silica-iron oxide nanocomposite

Fathy, Mohamed; Saad, Omnia A.; Elshemey, Wael M.; Fahmy, Heba M.

doi:10.1016/j.bbrc.2022.09.087

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…MCF-7 cells tend to show increased radio-sensitization enhancement; meanwhile, with 0.5 Gy dose, dose enhancement factor (DEF) values of cells treated with 5 and 10 µg/mL of SIONPs were 1.21 and 1.32, respectively. Results demonstrated that SIONPs potentially improve the radio-sensitivity of breast cancer [66]. Guerra et al [67] studied the radio-sensitization effects produced by gold and dextran-coated superparamagnetic iron oxide nanoparticles (SPION-DX) in M059J and U87 human glioblastoma cell lines irradiated by 6 MV photons beam.…”

Section: Iron-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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In recent years, there has been an increasing interest in using nanoparticles in the medical sciences. Today, metal nanoparticles have many applications in medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., and treatment with radiation. This paper reviews recent findings of recent metal nanotheranostics in medical imaging and therapy. The study offers some critical insights into using different types of metal nanoparticles in medicine for cancer detection and treatment purposes. The data of this review study were gathered from multiple scientific citation websites such as Google Scholar, PubMed, Scopus, and Web of Science up through the end of January 2023. In the literature, many metal nanoparticles are used for medical applications. However, due to their high abundance, low price, and high performance for visualization and treatment, nanoparticles such as gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, and lead have been investigated in this review study. This paper has highlighted the importance of gold, gadolinium, and iron-based metal nanoparticles in different forms for tumor visualization and treatment in medical applications due to their ease of functionalization, low toxicity, and superior biocompatibility.

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Section: Iron-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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“…The MCF-7 cells exhibit enhanced radiosensitization when subjected to a dose of 0.5 Gy. Dose enhancement factor (DEF) values of cells treated with 5 and 10 μg/mL of SPIONS were 1.21 and 1.32, respectively, displaying the potential improvement of radiosensitivity of breast cancer . In another work, Guerra and colleagues conducted a study examining the impact of gold and dextran-coated superparamagnetic iron-oxide NPs on radiosensitization effects in human glioblastoma cell line (M059J and U87) exposed to 6 MV photon beams .…”

Section: Nanoparticles Used For Theranostic Purposesmentioning

confidence: 99%

“…Dose enhancement factor (DEF) values of cells treated with 5 and 10 μg/mL of SPIONS were 1.21 and 1.32, respectively, displaying the potential improvement of radiosensitivity of breast cancer. 132 In another work, Guerra and colleagues conducted a study examining the impact of gold and dextran-coated superparamagnetic iron-oxide NPs on radiosensitization effects in human glioblastoma cell line (M059J and U87) exposed to 6 MV photon beams. 133 Maximum enhancement was observed in the U87 cell group employing SPION-DX nanoparticles with a core diameter of 21.1 nm when exposed to 50 ug/mL of NPs.…”

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confidence: 99%