“…Since 1996, multiple prospective studies have been performed revealing a dose response [2,[21][22][23]35] which resulted in a change of clinical practice by applying doses of 70-78 Gy during the last decade. Furthermore, new technologies, such as computerized treatment plan optimization, intensity-modulated radiotherapy (IMRT) and, most recently, image-guided radiotherapy (IGRT), have offered new possibilities for dose escalation [5, 6, 9, 11-13, 17, 19, 28, 31] enabling dose levels of ≥ 80 Gy [16,30,34]. Such doses are, in general, limited to prospective clinical studies performed by highly specialized radiotherapy centers, whereas in widespread daily clinical practice local doses so far applied range between 70-80 Gy.…”