Dose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS, and IMRT indices

Dahshan, Basem; Weir, Joshua; Bice, Robert P.; Renz, Paul; Cifarelli, Daniel T; Poplawski, Linda; Hack, Joshua; Vargo, John A.; Cifarelli, Christopher P.

doi:10.1016/j.brachy.2020.11.004

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…For combined treatments (see Supplementary Figure S4 ), cells were seeded as described previously, treated with ligand #190 (IC 25) and, after 72 h, irradiated in culture flasks at a single acute dose of 20 Gy with a cesium-137 ( 137 Cs) gamma ray source (Gammacell 40 Exactor, NORDION, Ottawa, ON, Canada) operating at a dose rate of 0.8 Gy/min (Istituto Superiore Sanità facility). A single radiation dose of 20 Gy was used, comparable to total doses delivered during radiation therapy in a fractionated regimen and to a single high dose used in special therapeutic modalities, such as intraoperative radiotherapy and stereotactic radiosurgery [ 75 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of the Combined Treatment with a G-Quadruplex-Stabilizing Ligand and Photon Beams on Glioblastoma Stem-like Cells: A Magnetic Resonance Study

Palma

Grande

Luciani

et al. 2021

IJMS

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Glioblastoma multiforme is a malignant primary brain tumor with a poor prognosis and high rates of chemo-radiotherapy failure, mainly due to a small cell fraction with stem-like properties (GSCs). The mechanisms underlying GSC response to radiation need to be elucidated to enhance sensitivity to treatments and to develop new therapeutic strategies. In a previous study, two GSC lines, named line #1 and line #83, responded differently to carbon ions and photon beams, with the differences likely attributable to their own different metabolic fingerprint rather than to radiation type. Data from the literature showed the capability of RHPS4, a G-quadruplex stabilizing ligand, to sensitize the glioblastoma radioresistant U251MG cells to X-rays. The combined metabolic effect of ligand #190, a new RHPS4-derivative showing reduced cardiotoxicity, and a photon beam has been monitored by magnetic resonance (MR) spectroscopy for the two GSC lines, #1 and #83, to reveal whether a synergistic response occurs. MR spectra from both lines were affected by single and combined treatments, but the variations of the analysed metabolites were statistically significant mainly in line #1, without synergistic effects due to combination. The multivariate analysis of ten metabolites shows a separation between control and treated samples in line #1 regardless of treatment type, while separation was not detected in line #83.

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Section: Methodsmentioning

confidence: 99%

Effects of the Combined Treatment with a G-Quadruplex-Stabilizing Ligand and Photon Beams on Glioblastoma Stem-like Cells: A Magnetic Resonance Study

Palma

Grande

Luciani

et al. 2021

IJMS

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“…For irradiation treatments, line #61 and #74 cells were seeded as described previously and after 72 h, cells were irradiated in culture flasks at a single acute dose of 20 Gy with a cesium-137 gamma ray source (Gammacell 40 Exactor, NORDION, Ottawa, ON, Canada) operating at a dose rate of 0.66 Gy/min at Istituto Superiore di Sanità, Rome, Italy. A single radiation dose of 20 Gy was used, comparable to total doses delivered during radiation therapy in a fractionated regimen and to a single high dose used in special therapeutic modalities, such as intraoperative radiotherapy and stereotactic radiosurgery [ 36 ]. MRS experiments were run on control and irradiated samples 72 h after irradiation for both lines.…”

Section: Methodsmentioning

confidence: 99%

Glioblastoma Stem-Like Cells (GSCs) with Mesenchymal Signature: Lipid Profiles of Mobile Lipids Obtained with MRS before and after Radio/Chemical Treatments

et al. 2022

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Glioblastoma is the most common and lethal primary malignant brain tumor in adults. Glioblastoma stem cells (GSCs) promote and are responsible for glioblastoma intratumoral heterogeneity and therapy resistance, due to their two main features: self-renewal and differentiation. Lipids have important biological and physiological functions that are critical for understanding the regulation and control of stem cell fate; lipid metabolism and related unsaturation levels play a possible role as the target of therapeutics to overcome glioblastoma radioresistance. This paper aimed at an in-depth analysis of 13 GSC mesenchymal (MES) lines, two subclones, and a stabilized glioblastoma line (T98G) by magnetic resonance spectroscopy (MRS). Particularly, 2D MRS was used to investigate lipid unsaturation behavior during growth in culture and after treatment with etomoxir and photon beams. MES lines, although belonging to the same genetic and metabolic cluster, showed metabolic heterogeneity when observed by MRS, focusing on lipid signals. Nonetheless, the observed unsaturation level stability for two representative lines after stressful treatments suggests unusual robustness of the unsaturation levels for each line, as a peculiar and intrinsic characteristic of GSCs.

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“…Compared to conventional radiation therapy, SRS uses smaller and more focused beams, resulting in a steep dose gradient and potentially worse dose homogeneity compared to conventional methods. [ 52 ] This poses a higher risk of radiation-induced damage to surrounding healthy tissues, especially when the tumor is located near critical structures. However, the highly focused nature of SRS allows for higher doses to be delivered to the tumor while sparing surrounding healthy tissues, which can be beneficial in certain cases.…”

Section: T Reatment P Lanningmentioning

confidence: 99%

Historical Progress of Stereotactic Radiation Surgery

Khaledi,

Khan,

Gräfe

2023

Journal of Medical Physics

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Radiosurgery and stereotactic radiotherapy have established themselves as precise and accurate areas of radiation oncology for the treatment of brain and extracranial lesions. Along with the evolution of other methods of radiotherapy, this type of treatment has been associated with significant advances in terms of a variety of modalities and techniques to improve the accuracy and efficacy of treatment. This paper provides a comprehensive overview of the progress in stereotactic radiosurgery (SRS) over several decades, and includes a review of various articles and research papers, commencing with the emergence of stereotactic techniques in radiotherapy. Key clinical aspects of SRS, such as fixation methods, radiobiology considerations, quality assurance practices, and treatment planning strategies, are presented. In addition, the review highlights the technological advancements in treatment modalities, encompassing the transition from cobalt-based systems to linear accelerator-based modalities. By addressing these topics, this study aims to offer insights into the advancements that have shaped the field of SRS, that have ultimately enhanced the accuracy and effectiveness of treatment.

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Dose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS, and IMRT indices

Cited by 11 publications

References 29 publications

Effects of the Combined Treatment with a G-Quadruplex-Stabilizing Ligand and Photon Beams on Glioblastoma Stem-like Cells: A Magnetic Resonance Study

Effects of the Combined Treatment with a G-Quadruplex-Stabilizing Ligand and Photon Beams on Glioblastoma Stem-like Cells: A Magnetic Resonance Study

Glioblastoma Stem-Like Cells (GSCs) with Mesenchymal Signature: Lipid Profiles of Mobile Lipids Obtained with MRS before and after Radio/Chemical Treatments

Historical Progress of Stereotactic Radiation Surgery

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