2009
DOI: 10.1200/jco.2008.18.7641
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Dose-Modified Oral Chemotherapy in the Treatment of AIDS-Related Non-Hodgkin's Lymphoma in East Africa

Abstract: PURPOSE Africa is burdened by the AIDS epidemic and attendant increase in HIV/AIDS-related malignancies. Pragmatic approaches to therapeutic intervention could be of great value. Dose-modified oral chemotherapy for AIDS-related non-Hodgkin's lymphoma is one such approach. PATIENTS AND METHODS The oral regimen consisted of lomustine 50 mg/m(2) on day 1 (cycle 1 only), etoposide 100 mg/m(2) on days 1 to 3, and cyclophosphamide/procarbazine 50 mg/m(2) each on days 22 to 26 at 6-week intervals (one cycle) for two … Show more

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Cited by 40 publications
(50 citation statements)
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“…Based on our experience and other similar reports from SSA [5153], continued efforts to diagnose patients earlier, treat them with standardized protocols, improve supportive care, and incorporate newer non-cytotoxic therapies can likely increase cure rates substantially even for HIV-infected patients in highly resource-limited settings [54]. Strategies testing lower-intensity, oral, metronomic approaches are also under evaluation with some promising early experience [55, 56]. …”
Section: Non-hodgkin Lymphomamentioning
confidence: 86%
“…Based on our experience and other similar reports from SSA [5153], continued efforts to diagnose patients earlier, treat them with standardized protocols, improve supportive care, and incorporate newer non-cytotoxic therapies can likely increase cure rates substantially even for HIV-infected patients in highly resource-limited settings [54]. Strategies testing lower-intensity, oral, metronomic approaches are also under evaluation with some promising early experience [55, 56]. …”
Section: Non-hodgkin Lymphomamentioning
confidence: 86%
“…38 There are limited data examining the impact of HIV on NHL survival in sub-Saharan Africa, although studies suggest that concurrent ART may render survival similar to patients without HIV. 33,39,40 …”
Section: Hivmentioning
confidence: 99%
“…Drug shortages have similarly interfered with lymphoma treatment even in the context of an internationally funded clinical trial. 33,40 A global commitment to providing essential drugs to developing countries is clearly articulated in Millennium Development Goal 8.E. Nevertheless, availability of essential †AWP per dose assumes a body surface area of 2 m 2 and weight of 80 kg.…”
Section: Chemotherapeutic Agentsmentioning
confidence: 99%
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