Dose of Histamine for Maximal Stimulation of Gastric Acid Secretion

Maximum acid output to graded doses of pentagastrin and its relation to parietal cell mass in Chinese patients with duodenal ulcer.

“…The difference may be related in part to the doses of histamine acid phosphate used. In Indians weighing between 40 and 60 kg, doses of histamine acid phosphate of 0 05 mg/kg for normal subjects and 0'06 mg/kg for duodenal ulcer patients were required for maximal stimulation (Desai et al, 1969), while in Singaporean Chinese the equivalent dose was found to be 0-06 mg/kg (Fung, 1970). Under such maximal stimulation, the Indians but not the Singaporean Chinese in these studies achieved a maximum acid output which was comparable with that of the Westerners.…”

“…Using a 'standard' dose of histamine acid phosphate (0-04 mg/kg) as stimulus, the maximum acid output (MAO) of Indians (Vakil and Mulekar, 1965;Goyal et al, 1966;Desai et al, 1969) and Singaporean Chinese (Fung, 1970) was about half the values obtained in Occidentals, both with respect to normal subjects and patients with duodenal ulcer. The difference may be related in part to the doses of histamine acid phosphate used.…”

Gastric acid secretion of normal Japanese subjects in relation to Helicobacter pylori infection, aging, and gender

“…In this study population, there was a substantial difference in mean body weight between men and women (66 AE 10 kg, 54 AE 9 kg, respectively). In a previous study it was demonstrated that when the dose of histamine, as a stimulant for gastric acid secretion, was calculated in relation to body weight, it did not yield maximal acid stimulation in lean populations (38,39). Although 4 mg/kg tetragastrin was used in this study, a smaller dose of tetragastrin administered to women may partly explain the difference in gastric acid secretion between male and female H. pylori-negative subjects.…”

Histamine and insulin dose-response studies of gastric secretion in Indian control subjects and patients with duodenal ulcer in the Ganges delta

“…Post stimulation 15minute periods Desai et al (1969) that to produce maximal stimulation of gastric acid, Indian subjects require a higher dose of histamine than do subjects of Western countries. Not only did our control subjects produce maximal secretion at a dose of 0 04 mg/kg, but there were no discernible differences between these and the ulcer patients where the dose of histamine required to produce peak acid output was concerned.…”

“…However, in Indian subjects an effective dose of insulin to stimulate gastric secretion has not been established, although various studies of histamine stimulated gastric acid secretion have been reported (Vakil and Mulekar, 1965;Goyal et al, 1966;Desai et al, 1967;Desai et al, 1969). Of particular interest is the study of Desai et al (1969) who showed that, in subjects weighing less than 60 kg, 0 04 mg/kg histamine acid phosphate provides a submaximal stimulus for gastric acid secretion.…”