Dose optimization of lithium to increase the uptake and retention of I-131 in rat thyroid

Kumar, Sanny B.; Kamal, Rozy; Khan, Anna Ara; Chadha, Vijayta Dani

doi:10.1007/s00411-019-00783-4

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Previous studies suggested that lithium carbonate could increase iodine retention in the thyroid, but the influence of lithium carbonate on iodine uptake is not well studied. Kumar reported a significant increase in the thyroid counts in lithium-treated rats afterI-131 administration at 4 h and 24 h, when compared to the control group [24]. In the present study, the data suggested that lithium carbonate treatment had little effect on the RAIUs at 2 h and 4 h, while RAIU measured at 24 h increased significantly.…”

Section: Discussionsupporting

confidence: 39%

Could effective iodine-131 half-life be extended by lithium carbonate in Graves’ disease patients: Results from a retrospective analysis

Gao,

Wu,

Zhou

et al. 2024

Biomol Biomed

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The effective iodine-131 (I-131) half-life (EHL) plays an important role in the evaluation of radioactive iodine therapy for Graves’ disease (GD) patients. It has been observed that the EHL of GD patients varies after taking lithium carbonate. The purpose of this study is to investigate whether EHL can be extended and to identify the predictive factors associated with this outcome. The clinical data of 225 GD patients were retrospectively reviewed. Patients were divided into two groups based on whether the ΔEHL was ≥ 0.5 days. EHL tested after lithium carbonate was defined as Li-EHL. In the univariate analysis, age, sex, thyrotropin receptor antibody (TRAb), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and baseline-EHL exhibited significant differences between the two groups (P < 0.05). Cutoff values of age and baseline-EHL to predict significant EHL extension were 40.5 years and 4.85 days, respectively, as determined by receiver operating characteristic (ROC) curve analysis. Multiple linear regression analysis further revealed that the regression equation, which included age, sex, baseline-EHL, and the FT3, free triiodothyronine (FT4)/free thyroxine(FT3) ratio, was statistically significant (P < 0.05). Li-EHL positively correlated with baseline-EHL and the FT4/FT3 ratio, but negatively correlated with age. Li-EHL was also increased in female individuals. In conclusion, age, sex, baseline-EHL and the FT4/FT3 ratio were associated with Li-EHL in GD patients.

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Section: Discussionsupporting

confidence: 39%

Could effective iodine-131 half-life be extended by lithium carbonate in Graves’ disease patients: Results from a retrospective analysis

Gao,

Wu,

Zhou

et al. 2024

Biomol Biomed

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“…Previous study suggested that lithium carbonate could increase iodine retention in thyroid, but the in uence of lithium carbonate on iodine uptake is not well studied. Kumar reported a signi cant increase in the thyroid counts in lithium treated rats after 131 I administration at 4 h and 24 h, when compared to control group [21]. In the present study, the data suggested that lithium carbonate treatment had little effect on the RAIUs at 2 h and 4 h, while RAIU measured at 24 h was increased signi cantly.…”

Section: 4roc Curvessupporting

confidence: 40%

Qualitative and quantitative impact of lithium carbonate pretreatment on the effective 131-I half-life in radioiodine therapy for hyperthyroidism: results from a retrospective study

Gao,

Wu,

Zhou

et al. 2024

Preprint

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Objective: The aim of this study is to evaluate the impact of lithium carbonate pretreatment on the effective 131I half-life (EHL) in radioiodine therapy (RIT) for hyperthyroidism. Design: This analysis of 225 patients diagnosed as hyperthyroidism at our institution between February 2015 and September 2021 was retrospectively registered (registration number: 2024-KY-0016, date: Jan 4, 2024). Methods: The basic clinical and laboratory examination data before and after lithium carbonate pretreatment was recorded. Whether the EHL was extended by ≥ 0.5 days has been established as the grouping basis. The differences of the clinical factors between the two groups were analyzed, and possible factors predicting whether longer EHL could be achieved was carried out using logistic regression analyses. Results and conclusions: The result showed that a 7-day lithium carbonate pretreatment could increase radioactive iodine uptake rate (RAIU) at 24 h (by 9.93%), EHL (by 8.17%), and decrease FT3 (by 20.85%), FT4 (by 11.93%) levels in hyperthyroidism patients in this retrospective study. It is indicated that not all patients with hyperthyroidism could achieve longer EHL after using lithium carbonate. Young female with positive TRAb, positive TgAb, low blood concentration of TPOAb, and/or short baseline EHL is more likely to achieve longer EHL after a short-term lithium carbonate administration.

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“…I selected 18 animals. Six in control group A2, on lab diet, to Group B rodents lithium at a dose of 20mg/kg OD 8 in flour pellets and Croup C albinos were given injection Methylcobalamin 500mcg 9 thrice daily for four weeks along with lithium carbonate 20mg /kg OD for above time period in flour pellets. On twenty eight day the animals were sacrificed, brain was removed; the cerebellum was separated from the rest of the brain and fixed in formaldehyde 10 for 24 hours.…”

Section: Methodsmentioning

confidence: 99%

Ameliorarting Action of Methylcaobalamin on Degenerated Cerebellar Molecular Cell Layer

Kohari¹,

Amjad²,

Malick³

2021

PJMHS

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Background: Cerebellum the hindbrain is located in the posterior cranial fossa.The cerebellar cortex consists, of a gray matter and a white matter and the gray matter comprises of outer molecular layer, middle purkinje cell layer and inner most is the granule cell layer. The antimaniac drug lithium caused distortion to the outer molecular cell layer which was repaired and the damage was lessened by injecting the albino rats with Methylcobalamin. Aim: To observe and document the data of the restored thickness of molecular cell layer after Methylcobalamin administration. Methods: Eighteen albino rats were selected and were treated with lithium and Methylcobalamin for a period of 4 weeks. Results: The results showed regeneration and improved thickness of molecular cell layer stressing the need for educating our masses in dietary use of vitamin b12 and the consultants to prescribe Methylcobalamin in neuronal injuries. Conclusion: My study proved that the use of vitamin b12 is mandatory in strengthening and restoring the cerebellar molecular gray matter. Keywords: Cerebellar molecular cell layer,Degeneration, Regeneration

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Dose optimization of lithium to increase the uptake and retention of I-131 in rat thyroid

Cited by 5 publications

References 24 publications

Could effective iodine-131 half-life be extended by lithium carbonate in Graves’ disease patients: Results from a retrospective analysis

Could effective iodine-131 half-life be extended by lithium carbonate in Graves’ disease patients: Results from a retrospective analysis

Qualitative and quantitative impact of lithium carbonate pretreatment on the effective 131-I half-life in radioiodine therapy for hyperthyroidism: results from a retrospective study

Ameliorarting Action of Methylcaobalamin on Degenerated Cerebellar Molecular Cell Layer

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