Dose optimization of nonionic contrast agent in dynamic computed tomography scanning of the abdomen and pelvis

Quantitative and Qualitative Evaluation of Volume of Low Osmolality Contrast Medium Needed for Routine Helical Abdominal CT

“…Bree et al [4] showed quantitatively that optimal hepatic enhancement could be produced by 125 mL of iohexol 350 injected at 2 mL/sec (total iodine = 43.7 g) despite the fact that the qualitative optimal hepatic enhancement was seen in those receiving 150 mL of iohexol 300 (total iodine = 45 g) at 2 mL /sec; however, both regimens increased hepatic enhancement by 50 H from baseline. Allen et al [19] reported results of a dose reduction study in which 45 patients were randomized to one of five groups receiving 100%, 75%, 60%, 50%, or 30% of 150 mL of ioversol 320. Diagnostic image quality in eight anatomic regions was assessed qualitatively, and quantitative analysis of density measurements in the abdominal aorta and inferior vena cava was performed.…”