1986
DOI: 10.1128/aac.29.5.849
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Dose ranging study of cefpimizole (U-63196E) for treatment of uncomplicated gonorrhea in men

Abstract: We conducted a two-center dose ranging study to evaluate the efficacy, tolerance, and toxicity of cefpimizole, a new cephalosporin, in the treatment of uncomplicated gonorrhea in 96 males. Twelve patients at each center were treated intramuscularly with single doses of 1.0, 0.5, 0.2$, and 0.125 g of cefpimizole. All urethral infections were cured at the highest dose, but lower doses produced progressively decreasing cure rates of 90% (0.5 g), 83% (0.25 g), and 71% (0.125 g). Despite recent declines in the repo… Show more

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