Dose ranging study on the effect of preoperative dexamethasone on postoperative quality of recovery and opioid consumption after ambulatory gynaecological surgery

Oliveira, Gildàsio S. De; Ahmad, Shireen; Fitzgerald, Paul C.; Marcus, R-Jay; Altman, C.; Panjwani, A.S.; McCarthy, Robert J.

doi:10.1093/bja/aer156

Cited by 127 publications

(83 citation statements)

References 33 publications

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“…Although the observed decrease in opioid consumption (21%) with the addition of an adductor canal block in addition to LIA in this study was less expected, the observed difference is clinically important. Opioid consumption in the immediate postsurgical period has been shown to be inversely related to quality of patient recovery, 27 and the observed reduction in opioid consumption in this study would likely be associated with improved quality of recovery. 28 Our findings must be interpreted within the context of the study's limitations.…”

Section: Discussionmentioning

confidence: 59%

Single-Dose Adductor Canal Block With Local Infiltrative Analgesia Compared With Local Infiltrate Analgesia After Total Knee Arthroplasty

Nader¹,

Kendall

Manning

et al. 2016

Regional Anesthesia and Pain Medicine

133

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Section: Discussionmentioning

confidence: 59%

Single-Dose Adductor Canal Block With Local Infiltrative Analgesia Compared With Local Infiltrate Analgesia After Total Knee Arthroplasty

Nader¹,

Kendall

Manning

et al. 2016

Regional Anesthesia and Pain Medicine

133

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show abstract

“…Therefore, dexamethasone should be useful in lowering pain, nausea and vomitting, due to its potential anti- inflammatory effect. Dexamethasone is the most powerful anti-inflammatory drug with a long half- life; and its administration is considered safe for periods shorter than two weeks even in amounts above physiological doses (10, 11). …”

Section: Introductionmentioning

confidence: 99%

The Effect of Single-Dose Administration of Dexamethasone on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy

et al. 2014

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Background:Postoperative pain is considered as a reason of patient’s delay in discharge and disability aggravation. Therefore, multimodal approaches have been suggested in order to mitigate pain and decrease postoperative side effects.Objectives:The aim of this study was to evaluate analgesic effect of a single dose injection of dexamethasone on reducing postoperative pain in laparoscopic cholecystectomy.Patients and Methods:In this double-blind, prospective study, 122 patients aged 18-60 years old, whom were selected for laparoscopic cholecystectomy, were classified into two case and control groups, and 61 patients were included in each group. The case (D) group underwent general anesthesia and a single- dose intravenous injection of dexamethasone. The Control (C) group received general anesthesia and intravenous injection of normal saline. Total dose of consumed meperidine and pain intensity during first 24 hours were evaluated in both groups.Results:No significant difference existed between two groups regarding age, sex, weight and operation time. Pain intensity in group D was significantly less than group C (P < 0.01) after two, six and 12 hoursof surgery. No significant difference existed in pain intensity between two groups at the beginning of and 24 hours after the surgery (P > 0.05). Meperidine consumption in group D was significantly less than group C (P < 0.05).Conclusions:Findings of present study showed that single dose of intravenous dexamethasone, led to less pain intensity and amounts of meperidine consumption, in comparison with placebo.

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“…The Quality of Recovery-9 (QoR-9) is a validated scale with 5 domains [20–22]. These measure physical comfort, emotional state, physical independence, psychological support, and pain.…”

Section: Methodsmentioning

confidence: 99%

Cardioprotection of Electroacupuncture for Enhanced Recovery after Surgery on Patients Undergoing Heart Valve Replacement with Cardiopulmonary Bypass: A Randomized Control Clinical Trial

Zhang

Xiao

2017

Evidence-Based Complementary and Alternative Medicine

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We attempted to investigate cardioprotection of electroacupuncture (EA) for enhanced recovery after surgery on patients undergoing heart valve replacement with cardiopulmonary bypass. Forty-four patients with acquired heart valve replacement were randomly allocated to the EA group or the control group. Patients in the EA group received EA stimulus at bilateral Neiguan (PC6), Ximen (PC4), Shenting (GV24), and Baihui (GV20) acupoints twenty minutes before anesthesia induction to the end of surgery. The primary end point was cardioprotection effect of electroacupuncture postoperatively and the secondary endpoints were quality of recovery and cognitive functioning postoperatively. The present study demonstrated that electroacupuncture reduced the occurrence of complications and played a role of cardioprotective effect on patients after heart valve replacement surgery with cardiopulmonary bypass, and it benefits patients more comfortable and contributes to recovery after surgery. This trial is registered with ChiCTR-IOC-16009123.

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Dose ranging study on the effect of preoperative dexamethasone on postoperative quality of recovery and opioid consumption after ambulatory gynaecological surgery

Abstract: Dexamethasone demonstrated dose-dependent effects on quality of recovery. Dexamethasone 0.1 mg kg(-1) reduced opioid consumption compared with dexamethasone 0.05 mg kg(-1), which may be beneficial for improving recovery after ambulatory gynaecological surgery.

Cited by 127 publications

References 33 publications

Single-Dose Adductor Canal Block With Local Infiltrative Analgesia Compared With Local Infiltrate Analgesia After Total Knee Arthroplasty

Single-Dose Adductor Canal Block With Local Infiltrative Analgesia Compared With Local Infiltrate Analgesia After Total Knee Arthroplasty

The Effect of Single-Dose Administration of Dexamethasone on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy

Cardioprotection of Electroacupuncture for Enhanced Recovery after Surgery on Patients Undergoing Heart Valve Replacement with Cardiopulmonary Bypass: A Randomized Control Clinical Trial

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