Dose recommendations for intravenous colistin in pediatric patients from a prospective, multicenter, population pharmacokinetic study

Abstract

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Pharmacokinetics of Antimicrobials in Children with Emphasis on Challenges Faced by Low and Middle Income Countries, a Clinical Review

“…Infants and children, especially those in the post-traumatic or post-operative period, having sepsis, burns or hematologic malignancies are at a higher risk of ARC [131,132]. In order to maintain adequate drug exposure in such children, either prolonged infusions, frequent dosing and increased dosing or change to an alternative antimicrobial drug are required [133][134][135].…”