Dose‐related analgesic effects of flupirtine.

Hummel, Thomas; Friedmann, T.; Pauli, E.; Niebch, G.; Borbe, H.O.; Kobal, Gerd

doi:10.1111/j.1365-2125.1991.tb05615.x

Cited by 36 publications

(43 citation statements)

References 14 publications

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“…This was indicated by the decrease of CSSERP amplitude P2 [16,27,36]. It has previously been demonstrated that event-related potentials represent an objective tool for assessment of pain and analgesic effects [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Thus, our data indicate the presence of analgesic effects of both flurbiprofen enantiomers.…”

Section: Discussionmentioning

confidence: 56%

“…Changes in CSSERP amplitudes were found largest with 100 mg (R)-flurbiprofen, which reduced amplitude P2 by 36%. Compared with other analgesics investigated with the same model, the magnitude of this effect was superior to the effects produced by 800 mg ibuprofen [25] and 1000 mg acetylsalicylic acid [22] and was comparable with the effects observed after injection of 30 mg pentazocine [22] or 0.2 mg fentanyl [37] or after oral administration of 200 mg flupirtine [23]. However, there is a need to compare (R)-flurbiprofen directly with other non-opioid analgesics like paracetamol or with opioids.…”

Section: Discussionmentioning

confidence: 96%

“…One of the advantages of this technique is that the method is non-invasive and the results seem negligibly influenced by non-analgesic drug effects [24,30]. So far, this model has been applied in quantifying the analgesic activity of both opioid and nonopioid analgesics [22][23][24][25]34].…”

Section: Introductionmentioning

confidence: 99%

“…Using a variety of stimulation techniques, ERPs have been shown to correlate well with the ratings of pain intensity [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Furthermore, event-related potentials have been used to assess the analgesic effects of numerous drugs [15,[21][22][23][24][25][26]. For example, Kobal and co-workers established an experimental pain model based on chemo-somatosensory event-related potentials (CSSERP) in response to painful stimulation of the nasal mucosa with carbon dioxide [12,[27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

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Effects of flurbiprofen enantiomers on pain‐related chemo‐somatosensory evoked potentials in human subjects.

Lötsch

Geißlinger

Mohammadian

et al. 1995

Brit J Clinical Pharma

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1 The aim of the study was to investigate the analgesic effects of flurbiprofen enantiomers using an experimental pain model based on both chemo-somatosensory event-related potentials (CSSERP) and subjective pain ratings. 2 Healthy female volunteers (n = 16, age 23-36 years) participated in a placebocontrolled, randomised, double-blind, four-way crossover study. Single doses of (S)-flurbiprofen (50 mg), (R)-flurbiprofen (50 and 100 mg) and placebo were administered orally. Measurements were taken before and 2 h after administration of the medications. During each measurement, 32 painful stimuli of gaseous carbon dioxide (200 ms duration, interval approximately 30 s) of two concentrations (60 and 65% CO2 v/v) were applied to the right nostril. EEG was recorded from five positions and CSSERP were obtained in response to the painful C02-stimuli. Additionally, subjects rated the perceived intensity of the painful stimuli by means of a visual analogue scale (VAS). 3 The CSSERP-amplitude P2, a measure of analgesic effect, decreased after administration of both (R)-and (S)-flurbiprofen, while it increased after placebo. This was statistically significant at recording positions C4 (P < 0.01) and Fz (P < 0.05).The analgesia-related decreases in evoked potential produced by (R)-flurbiprofen were dose-dependent. Comparing similar doses of (R)-and (S)-flurbiprofen, the decrease in CSSERP-amplitudes produced by the (S)-enantiomer was somewhat more pronounced, indicating a higher analgesic potency. 4 The present data indicate that both enantiomers of flurbiprofen produce analgesic effects. Since (R)-flurbiprofen caused only little toxicity in rats as compared with the (S)-enantiomer or the racemic compound, a reduction of the quantitatively most important side effects in the gastrointestinal tract might be achieved by employing (R)-flurbiprofen in pain therapy.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of flurbiprofen enantiomers on pain‐related chemo‐somatosensory evoked potentials in human subjects.

Lötsch

Geißlinger

Mohammadian

et al. 1995

Brit J Clinical Pharma

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“…Furthermore, the chemo-somatosensory evoked potential (CSSEP) pain model has been successfully employed to quantify the effects of several central-acting analgesics [7]. Thus, the aim of the present study was to investigate the acute analgesic effectiveness of oral lamotrigine using the CSSEP pain model.…”

Section: Discussionmentioning

confidence: 99%

Effects of lamotrigine on pain‐induced chemo‐somatosensory evoked potentials

Klamt¹,

Posner

1999

Anaesthesia

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SummaryLamotrigine, a sodium channel blocker that selectively inhibits the neuronal release of glutamate, has been shown to produce analgesia in acute and chronic pain models in rats without causing noticeable sedation. After oral administration it also reduces pain scores, as assessed by the cold pain test, in volunteers. The purpose of this study was to determine the analgesic effect of lamotrigine given by mouth to healthy volunteers as evidenced by alterations in chemosomatosensory evoked potentials. The following factors were measured: latency to N 1 and P 100 peak (ms); amplitude between the N 1 and P 100 peak (mV); visual analogue pain intensity scores. A double-blind, randomised and crossover design was used in which 12 volunteers received either placebo or lamotrigine 300 mg on separate occasions as determined by the randomisation schedule. Volunteers were tested before and 2 h after the treatment. The plasma lamotrigine concentration was measured immediately after the end of the experimental sessions. Lamotrigine produced a significantly higher latency to P 100 values at 2 h postdrug than placebo (p < 0.05) but had no significant effects on the other factors. Although plasma concentrations were similar to those observed in the cold pain test, we conclude that lamotrigine 300 mg by mouth had no analgesic effect in this acute pain model. Preto -SP, Brazil. CEP 14010-190 Accepted: 16 March 1998 Lamotrigine is a novel antiepileptic drug indicated for treatment of partial and generalised tonic clonic seizures. It is thought to act primarily by stabilising the presynaptic neuronal membrane by blocking voltage-dependent Na þ channels, thereby preventing the pathological release of excitatory neurotransmitters, principally glutamate [1-3]. Nakamura-Craig and Follenfant [4,5] have shown that oral administration of lamotrigine produces analgesia in acute (subplantar injection of PGE 2 ) and chronic (diabetic neuropathy and loose sciatic ligation) models of hyperalgesia in rats. A pilot study with volunteers using the coldpain test indicated that a single oral dose of lamotrigine 300 mg caused a significant reduction in subjective pain (unpublished data).Short painful chemical (CO 2 ) stimuli applied to the nasal mucosa elicit responses (late nearfield potentials) that significantly correlate with subjective pain ratings [6]. Furthermore, the chemo-somatosensory evoked potential (CSSEP) pain model has been successfully employed to quantify the effects of several central-acting analgesics [7]. Thus, the aim of the present study was to investigate the acute analgesic effectiveness of oral lamotrigine using the CSSEP pain model. Methods

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Therapie mit Analgetika und nicht-steroidalen Antirheumatika

Hackenthal¹

1993

Pharmakotherapie Und Alter

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Dose‐related analgesic effects of flupirtine.

Cited by 36 publications

References 14 publications

Effects of flurbiprofen enantiomers on pain‐related chemo‐somatosensory evoked potentials in human subjects.

Effects of flurbiprofen enantiomers on pain‐related chemo‐somatosensory evoked potentials in human subjects.

Effects of lamotrigine on pain‐induced chemo‐somatosensory evoked potentials

Therapie mit Analgetika und nicht-steroidalen Antirheumatika

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