Dose-related caffeine discrimination in normal volunteers

Sm, Evans; Rr, Griffiths

doi:10.1097/00008877-199109000-00011

Cited by 28 publications

(4 citation statements)

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“…12,13 Persons consuming caffeine regularly may develop a withdrawal syndrome with caffeine cessation. 14 –19 Symptoms include headache, drowsiness, lethargy, fatigue, muscle pain or stiffness, impaired psychomotor performance, difficulty concentrating, and physiological complaints such as nausea and excessive yawning. Symptoms have occurred in some persons after cessation of doses as low as 100 mg of caffeine per day.…”

Section: Introductionmentioning

confidence: 99%

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Topographic Quantitative EEG Response to Acute Caffeine Withdrawal: A Comprehensive Analysis of Multiple Quantitative Variables

Reeves

Struve

Patrick

2002

Clinical Electroencephalography

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Most previous studies of the neurophysiological effects of caffeine have focused on the effects of caffeine ingestion, and few studies have examined the effects of caffeine withdrawal. This open study evaluated the quantitative EEG (QEEG) changes occurring during a 4-day period of abstinence in subjects who habitually consume 300 mg or more of caffeine daily. Thirteen subjects underwent QEEG studies during their usual caffeine consumption (baseline) and on days 1, 2, and 4 of a 4-day period of caffeine abstinence. Ten of the subjects underwent a second QEEG on day 4 that consisted of a period of recording after reinstitution of caffeine. A comprehensive analysis of multiple quantitative variables was performed for each study during the abstinence period and compared to the variables obtained at baseline for each subject. Changes occurring during caffeine abstinence included: 1) increases in theta absolute power over all cortical areas, 2) increases in delta absolute power over the frontal cortex, 3) decreases in the mean frequency of both the alpha and beta rhythm, 4) increase in theta relative power and decrease in beta relative power, and 5) significant changes in interhemispheric coherence. Most of these changes tended to return to pre-abstinence baseline levels rapidly after resumption of caffeine consumption. The caffeine withdrawal state affects a number of neurophysiological variables. Further investigation of the neurophysiological aspects of caffeine withdrawal using placebo controlled double blind assessment methods is warranted.

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Section: Introductionmentioning

confidence: 99%

“…Symptoms have occurred in some persons after cessation of doses as low as 100 mg of caffeine per day. 15,16…”

Section: Introductionmentioning

confidence: 99%

Topographic Quantitative EEG Response to Acute Caffeine Withdrawal: A Comprehensive Analysis of Multiple Quantitative Variables

Reeves

Struve

Patrick

2002

Clinical Electroencephalography

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“…During the last several years there has been a great deal of interest in the neurophysiological effects of caffeine withdrawal. Several investigators 1 –6 have shown that persons habitually consuming low or moderate amounts of caffeine may develop a withdrawal syndrome with caffeine cessation. Symptoms include headaches, drowsiness, lethargy, fatigue, muscle pain or stiffness, impaired psychomotor performance, difficulty concentrating and physiological complaints such as nausea and excessive yawning.…”

Section: Introductionmentioning

confidence: 99%

“…Symptoms have occurred in some persons after cessation of dosages as low as 100 mg per day of caffeine. 2,3…”

Section: Introductionmentioning

confidence: 99%

The Effects of Caffeine Withdrawal on Cognitive P300 Auditory and Visual Evoked Potentials

Reeves

Struve

Patrick

1999

Clinical Electroencephalography

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Auditory and visual P300 cognitive evoked potentials were obtained in 13 individuals who regularly consumed caffeine prior to and during a 4 day period of abstinence from caffeine. During the period of caffeine abstinence auditory P300 evoked potentials showed significant decreases in amplitude measures but no significant changes in latency, while the visual P300 evoked potentials showed significant latency decreases but no significant changes in amplitude. The reason for these opposite effects is unclear and further research in this area is needed.

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