Dose-related Effect of Statins in Venous Thrombosis Risk Reduction

Khemasuwan, Danai; Chae, Young Kwang; Gupta, Shikha; Carpio, Alejandra; Yun, Jeong H.; Neagu, S; Lucca, Anabella B.; Valsecchi, Matías E.; Mora, Jorge

doi:10.1016/j.amjmed.2011.04.019

Cited by 38 publications

(28 citation statements)

References 35 publications

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“…Besides having a lipidlowering effect, a statin is associated with a reduction in all causes of death from non-obstructive coronary artery disease [4]. Additionally, some authors have found it to have a positive effect on vascular inflammation [5], and linked it to a lower risk of developing venous thromboembolism [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of alpha-tocopherol associated with lovastatin on brain tissue and memory function in SHRSPs

Guimarães

Murad

Paganelli

et al. 2015

Physiology & Behavior

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Strokes are preceded by oxidative stress and inflammation, two processes linked to atherosclerosis and hypertension. Statins have been widely employed to control atherosclerosis; however, there could be neurological implications to its use—including cognitive impairment. Thus,we aimed to determine whether alpha-tocopherol is capable of reversing the neurological side effects of statins and enhancing its anti-inflammatory properties. To assess these effects, 15-week-old stroke-prone spontaneously hypertensive rats (SHRSPs) were divided into four groups (n = 6, each): alpha-tocopherol (AT), lovastatin (LoV), alpha-tocopherol + lovastatin (AT + LoV), and control (C).We administered 120 IU of alpha-tocopherol diluted in 0.1 ml of coconut oil,whereas the dose of lovastatin was administered at a ratio of 1 mg/kg of rat body weight. The control group received 0.1 ml coconut oil. All animals received the treatments via orogastric gavage.We assessed body weight, diuresis, food and water intake, oxidative stress (malondialdehyde levels), the total cellular injury marker (lactate dehydrogenase), short and long-term memory, cognition, and histopathological changes in the hippocampus. The results demonstrated that lovastatin treatment did not negatively affect the memory of our animal model. In fact, the animals treated with AT and LoV showed improvement in memory and cognition. Additionally, both treatments decrease lactate dehydrogenase and oxidative stress levels. Furthermore, our study also demonstrated hippocampal tissue preservation in the treated groups.

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Section: Introductionmentioning

confidence: 99%

Effects of alpha-tocopherol associated with lovastatin on brain tissue and memory function in SHRSPs

Guimarães

Murad

Paganelli

et al. 2015

Physiology & Behavior

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show abstract

“…On the other hand, novel treatments targeting endothelial dysfunction or atherosclerotic inflammation might be safer and, thus, should be investigated in both primary and secondary prevention of VTE. For instance, treatment with statins has been shown to markedly reduce the risk of venous thrombosis in a dose-related manner (16). Importantly, this beneficial effect was further improved by concomitant treatments with an antiplatelet drug (16), indicating that combined anti-atherosclerotic treatment might selectively improve also VTE.…”

Section: Invited Editorial Focusmentioning

confidence: 97%

Should we focus on “venous vulnerability” instead of “plaque vulnerability” in symptomatic atherosclerotic patients?

Montecucco¹,

Mach²

2011

Thromb Haemost

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“…5). In contrast to other lipid-lowering drugs, statins are therapeutic and also preventative against VTE among at-risk medical inpatients and also general population in a dose-dependent manner, however this effect has not been observed in elderly population [93,[96][97][98][99][100][101].…”

Section: Temporality Of Inflammatory Events Following Ptementioning

confidence: 99%