Dose-response association between cardiovascular health and mortality in cancer survivors

Background The present study aimed to investigate the association between physical activity before the incidence of cardiovascular disease (CVD) and clinical outcomes in cancer survivors. Methods and Results We analyzed 904 cancer survivors (median age [interquartile range] 75 [68–80] years; 297 [32.9%] patients were female) who required hospitalization for treatment of CVD. The amount of physical activity 1 month before the admission was assessed using the 3-question (3Q) assessment tool, and categorized as minimal, low, adequate, and high according to physical activity level. The primary outcome was the composite events of all-cause death and/or rehospitalization for CVD up to 1 year after discharge. The total amount of physical activity was identified in 544 (60.2%) patients in the minimal group, 95 (10.5%) in the low group, 253 (28.0%) in the adequate group, and 12 (1.3%) in the high group. A total of 686 (75.9%) patients completed follow up, with 252 (27.9%) composite events occurring. Even after adjustment for various confounders, higher physical activity was significantly associated with a lower composite event rate (adjusted hazard ratio [95% confidence interval] 0.859 [0.833–0.900]). Conclusions High physical activity in cancer survivors was associated with a lower composite event rate after treatment for CVD. Assessment of prehospital physical activity using the 3Q score may be useful in their risk stratification.

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Adherence to Life's Essential 8 is associated with reduced all-cause and cause-specific mortality in individuals with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2005-2018

Li,

Yu,

Zhang

et al. 2024

Preprint

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The American Heart Association updated the cardiovascular health (CVH) assessment tool, the Life's Essential 8 (LE8). Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease worldwide and is associated with excessive mortality risk. 10050 participants with MASLD were included from NHANES 2005–2018. LE8 was assessed by combining 4 health behaviors and 4 health factors, with 0–49 being low CVH, 50–79 being moderate CVH, and 80–100 being high CVH. In the fully adjusted model, each point increase in the LE8 score was associated with a 2.7%, 2.7%, and 1.6% decrease in all-cause, CVD, and cancer mortality risk, respectively, in people with MASLD. Compared to low CVH, being in moderate/high CVH was negatively associated with most mortality outcomes, while health factors lost significant association with cancer mortality. Most of the associations showed dose-response associations, except for health factors and all-cause mortality and LE8 and CVD mortality. Race/ethnicity and income-poverty ratio significantly influenced the association between LE8 and all-cause mortality.LE8 was associated with significantly lower all-cause, CVD, and cancer mortality in people with MASLD. Assessment of CVH by LE8 may contribute to targeted healthy lifestyle and factor modification to prevent excess mortality in MASLD.

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Dose-response association between cardiovascular health and mortality in cancer survivors

Cited by 4 publications

References 31 publications

Association of life’s essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

Association of life’s essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

Association Between Amount of Physical Activity and Clinical Outcomes After Treatment for Cardiovascular Disease in Cancer Survivors

Adherence to Life's Essential 8 is associated with reduced all-cause and cause-specific mortality in individuals with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2005-2018

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