Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population

Li, YangFan; He, Fei; He, Yun; Pan, Xinting; Wu, Yunli; Hu, Zhijian; Lin, Xu; Xu, Shuai; Peng, Xian-E

doi:10.1136/bmjopen-2018-026854

Cited by 17 publications

(18 citation statements)

References 41 publications

(31 reference statements)

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“…Further increases in physical activity (1000 MET-minutes/week) were associated with a 33% risk reduction in NAFLD (RR = 0.67, 95% CI 0.54-0.83). These findings are consistent with those of Li and colleagues who reported that moderate-and vigorous-intensity physical activity effectively reduced the risk of NAFLD independent of energy intake and sedentary time (>684 MET-minutes/week compared to none: OR 0.58, 95% CI 0.40 to 0.86, vigorous-intensity physical activity: >960 MET-min/week compared to none: OR 0.63, 95% CI 0.41 to 0.95) [39]. Li et al used ultrasound measurements to assess LF.…”

Section: Exercise and Liver Fatsupporting

confidence: 89%

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Negative Energy Balance Induced by Exercise or Diet: Effects on Visceral Adipose Tissue and Liver Fat

2020

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The indisputable association between visceral adipose tissue (VAT) and cardiometabolic risk makes it a primary target for lifestyle-based strategies designed to prevent or manage health risk. Substantive evidence also confirms that liver fat (LF) is positively associated with increased health risk and that reduction is associated with an improved metabolic profile. The independent associations between reductions in VAT, LF, and cardiometabolic risk is less clear. In this narrative review, we summarize the evidence indicating whether a negative energy balance induced by either an increase in energy expenditure (aerobic exercise) or a decrease in energy intake (hypocaloric diet) are effective strategies for reducing both VAT and LF. Consideration will be given to whether a dose-response relationship exists between the negative energy balance induced by exercise or diet and reduction in either VAT or LF. We conclude with recommendations that will help fill gaps in knowledge with respect to lifestyle-based strategies designed to reduce VAT and LF.

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Section: Exercise and Liver Fatsupporting

confidence: 89%

“…Hallworth and colleagues randomized participants to 12 weeks of HITT on a cycle ergometer three times a week. Participants were instructed to perform 5 intervals of cycling at 16-17 on the Borg scale for 3 min followed by 3 min of recovery [39]. Abdelbasset et al randomized participants to an eight-week cycling protocol.…”

Section: Exercise and Liver Fatmentioning

confidence: 99%

Negative Energy Balance Induced by Exercise or Diet: Effects on Visceral Adipose Tissue and Liver Fat

2020

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“… 17 This dose-dependent negative association of physical activity with CLD in our study is also consistent with data reporting a dose-response association between physical activity and NAFLD. 18 Based on our data, an additional walk of 40 min per day ( e.g. change from quartile 1 to quartile 2) could decrease the risk of liver disease development by 22%.…”

Section: Discussionmentioning

confidence: 70%

Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Schneider¹,

Zandvakili²,

Thaiss³

et al. 2021

JHEP Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…31 Another case-control study found that among men physical activity was inversely associated with the risk of NAFLD in a dose-dependent manner. 32 A review emphasized the independent effect of physical activity, including aerobic exercise in the treatment of NAFLD. 33 Exercise increases fatty acid oxidation, decreases fatty acid synthesis, and prevents mitochondrial and hepatocellular damage.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Non-Alcoholic Fatty Liver Disease Among the Patients Admitted to a Teaching Hospital in Sri Lanka: Case Control study

Nissanka¹,

Abeysena

2020

Preprint

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Background: The burden of Non-Alcoholic Fatty Liver Disease (NAFLD) was rising globally. It was the disease condition where there was increase fat deposition (≥5%) in the hepatic cells. The objective of this study was to determine the risk factors for NAFLD among the patients admitted to a Teaching Hospital in Sri Lanka.Methods: A case control study was conducted among the 106 cases with NAFLD and 212 unmatched hospital-based controls without having NAFLD. A case was defined based on the presence of fatty liver according to the diagnostic ultrasonographic criteria. Those were increase echogenicity of the liver compared to kidney and spleen, obliteration of vascular architecture, and deep attenuation of ultrasonic signals. There should be at least two out of three criteria to diagnosed as NAFLD. The data was collected by using an interviewer-administered questionnaire. The risk factors were determined by using multiple logistic regression and the results were interpreted by using adjusted odds ratio (AOR) and 95 % confidence interval (95% CI).Results: The risk factors for NAFLD were found as the fast food consumption more than 1 time per week (AOR=9.34, 95% CI= 4.47-19.49), none consumption of coffee (AOR=2.78, 95% CI= 2.78-1.32), family history of liver disease (AOR=12.2, 95% CI= 2.16-67.97), methotrexate usage (AOR=32.02, 95% CI=1.45-707.29), inadequate physical activity (AOR=8.10, 95% CI= 4.04-16.26), high BMI value more ≥23Kg/m2 (AOR=6.17, 95% CI=2.93-12.99) Being a Sinhalese (AOR=12.7, 95% CI=2.03-79.33).Conclusion: There were seven independent risk factors for NAFLD were identified. Among those, most of the risk factors were modifiable risk factors such as inadequate physical activity, High BMI value (≥ 23Kg/m2) with overweight, infrequent coffee consumption, and increase fast-food consumption. It should be taken primary preventive strategies for those modifiable risk factors to prevent NAFLD.

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Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population

Cited by 17 publications

References 41 publications

Negative Energy Balance Induced by Exercise or Diet: Effects on Visceral Adipose Tissue and Liver Fat

Negative Energy Balance Induced by Exercise or Diet: Effects on Visceral Adipose Tissue and Liver Fat

Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Risk Factors for Non-Alcoholic Fatty Liver Disease Among the Patients Admitted to a Teaching Hospital in Sri Lanka: Case Control study

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