1995
DOI: 10.1016/0022-2828(95)90012-8
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Dose/response curves of lipoic acid R- and S-forms in the working rat heart during reoxygenation: Superiority of the R-enantiomer in enhancement of aortic flow

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Cited by 19 publications
(11 citation statements)
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“…These findings corroborate the results obtained by our previous study, showing the identical capacity of LA in isolated perfused rat livers (17). The potency of LA to increase ATP levels in rat heart mitochondria has been reported by another group (26). This gives rise to the question as to how LA increases ATP levels in liver tissue after ischemia/reperfusion.…”
Section: Discussionsupporting
confidence: 93%
“…These findings corroborate the results obtained by our previous study, showing the identical capacity of LA in isolated perfused rat livers (17). The potency of LA to increase ATP levels in rat heart mitochondria has been reported by another group (26). This gives rise to the question as to how LA increases ATP levels in liver tissue after ischemia/reperfusion.…”
Section: Discussionsupporting
confidence: 93%
“…However, although only R-LA has been identified as the biologically active form of LA (32), R,S-LA has been administered in therapeutic applications as well as in food supplements simply due to more cost-efficient achiral production processes that were introduced in the 1950s (33). Whereas S-LA (as free form or in R,S-LA) is considered non-toxic, there is evidence that S-LA can adversely affect the activity of R-LA (34). To test whether this effect can be attributed to the cellular delivery of LA by the Na ϩ /multivitamin transporter, the transport system suggested to be central in the transport of LA (16), we characterized the interaction of LA with hSMVT using transport and binding studies.…”
Section: Discussionmentioning
confidence: 99%
“…As is becoming evident from the foregoing discussion, in mitochondria, oligomycin -sensitive thiol reactivity occurs to a remarkable extent [1,4,7,8,[18][19][20]33,43,57,58,61,62,64,66]. Such mitochondrial -SH reactivity can be also deduced to working rat hearts in experimentation with MPG [65] and alpha lipoic acid [67].…”
Section: Discussionmentioning
confidence: 98%