Dose–response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate

Gasco, Manuel; Villegas, León; Yucra, Sandra; Rubio, Julio; Gonzales, Gustavo F.

doi:10.1016/j.phymed.2006.12.003

Cited by 54 publications

(54 citation statements)

References 18 publications

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“…Maca has been traditionally used for food and to increase nutrition and human fertility. In recent years, maca has gained significant interest due to its variety of bioactivities, such as fertility-enhancing properties [2,3], sexual function improvement [4], antifatigue [5,6], increasing immunity function [7], inhibition of prostate hyperplasia [8], and reducing menopause syndrome [9] that have been demonstrated by previous studies.…”

Section: Introductionmentioning

confidence: 99%

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Gan

Feng

et al. 2017

Journal of Food Quality

118

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The antioxidant capacity of maca has been considered to be the basis for other bioactivities, and revealing the active antioxidant compounds would help to elucidate a variety of bioactive compounds. In this study, the correlation between the antioxidant activity of maca and secondary metabolites, including ferric reducing antioxidant potential (FRAP), hydroxyl radical scavenging ability (HRSA), lipid peroxidation inhibition ability (LPIA), total phenolic contents (TPCs), total alkaloid contents (TACs), and total sterol contents (TSCs), was investigated by measuring. Chloroform was selected to be an efficient extraction solvent for antioxidant compounds in maca by polarity fractions test. The results showed that TPC exhibited significant linear correlations ( < 0.05) to FRAP and LPIA, while TAC had significant linear correlations ( < 0.05) to FRAP, HRSA, and LPIA. These results suggested that alkaloids and phenols were the most important substances for the antioxidation of maca, of which the antioxidant effect of alkaloids seemed to be higher than that of phenols.

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Section: Introductionmentioning

confidence: 99%

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Gan

Feng

et al. 2017

Journal of Food Quality

118

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“…Maca extracts are used for the treatment of a wide range of pathological conditions such as sexual infertility, osteoporosis, and benign prostatic hyperplasia [13,14]. On the contrary, limited evidence of efficacy against persistent pain has been described up to now [15].…”

Section: Introductionmentioning

confidence: 99%

Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats

Tenci

Mannelli

Maresca

et al. 2017

Zeitschrift Für Naturforschung C

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Lepidium meyenii (Walp.), commonly called maca, is an Andean crop belonging to the Brassicaceae family. Maca hypocotils are habitually consumed as customary food as well as traditional remedies for pathological conditions such as infertility. Moreover, the characterization of maca extracts revealed the presence of compounds that are able to modulate the nervous system. Aimed to evaluate the efficacy of L. meyenii in persistent pain, the present study analyzed the effects of a commercial root extract from maca in different animal models reproducing the most common causes of chronic painful pathologies. A qualitative characterization of this commercial extract by high performance liquid chromatography-mass spectrometry and tandem mass spectrometry analyses allowed us to confirm the presence of some macamides known as bioactive constituents of this root and the absence of the main aromatic glucosinolates. The acute oral administration of maca extract is able to reduce mechanical hypersensitivity and postural unbalance induced by the intra-articular injection of monoiodoacetate and the chronic-constriction injury of the sciatic nerve. Furthermore, L. meyenii extract reverts pain threshold alterations evoked by oxaliplatin and paclitaxel. A good safety profile in mice and rats was shown. In conclusion, the present maca extract could be considered as a therapeutic opportunity to relieve articular and neuropathic pain.

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“…16 Recently, the antidepressantrelevant medicinal properties of maca were reported. López-Fando et al reported that maca had antistress activity in a rat model.…”

Section: Introduction Dmentioning

confidence: 99%

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

Cheng

et al. 2014

Journal of Medicinal Food

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Maca has been consumed as a medical food in Peru for thousands of years, and exerts anxiolytic and antidepressant effects. Our present study aimed to evaluate the behavior and anatomical and biochemical effects of petroleum ether extract from maca (ME) in the chronic unpredictable mild stress (CUMS) model of depression in mice. Three different doses of maca extract (125, 250, and 500 mg/kg) were orally administrated in the six-week CUMS procedure. Fluoxetine (10 mg/kg) was used as a positive control drug. Maca extract (250 and 500 mg/kg) significantly decreased the duration of immobility time in the tail suspension test. After treatment with maca extract (250 and 500 mg/kg), the granule cell layer in the dentate gyrus appeared thicker. Maca extract (250 and 500 mg/kg) also induced a significant reduction in corticosterone levels in mouse serum. In mouse brain tissue, after six weeks of treatment, noradrenaline and dopamine levels were increased by maca extract, and the activity of reactive oxygen species was significantly inhibited. Serotonin levels were not significantly altered. These results demonstrated that maca extract (250 and 500 mg/kg) showed antidepressant-like effects and was related to the activation of both noradrenergic and dopaminergic systems, as well as attenuation of oxidative stress in mouse brain.

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Dose–response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate

Cited by 54 publications

References 18 publications

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

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