Dose‐response relationship and time course of action of Org 9426

Lambalk, L.M; Wit, Arjaan; Wierda, J. M. K. H.; Hennis, P. J.; Ágoston, S.

doi:10.1111/j.1365-2044.1991.tb09843.x

Cited by 44 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These resuts are in accordance with those of other recent studies [5,12,[20][21][22], which showed no significant differences in the onset times of rocuronium under volatile anesthetics. In our study, the shortest onset time (90.67 s) was observed in the sevoflurane group.…”

Section: Resultssupporting

confidence: 95%

Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium

Güngör

Bozkırlı

Çelebi

et al. 2003

Journal of Anesthesia

View full text Add to dashboard Cite

Materials and methodsForty-five unpremedicated ASA class I or II patients scheduled to undergo either orthopedic or ear, nose, and throat surgery under general anesthesia with an anticipated duration of approximately 1.5-3 h were enrolled in this study after approval of the hospital ethics committee and written informed consent from the patients had been obtained. All patients were free from neuromuscular, endocrine, liver, or renal diseases and were not receiving drugs known to interact with neuromuscular blocking agents. They required muscle relaxation only for endotracheal intubation.An intravenous infusion of 0.9% sodium chloride solution was given initially via the basilic vein on one of the arms, while the other arm was kept for monitoring neuromuscular block. The heart rate (HR), mean arterial pressure (MAP), peripheral oxygen saturation (SpO 2 ) (Odam Physiogard SM 785, Wissenbourg, France), and end-tidal concentrations of CO 2 and volatile anesthetics (Artema MM 256, Sundbyberg, Sweden) were monitored. Each patient was allocated to one of three groups: enflurane (group E, n ϭ 15), sevoflurane (group S, n ϭ 15), and neuroleptanesthesia (group NA, n ϭ 15). The induction of anesthesia was performed with i.v. fentanyl 2 µg · kg Ϫ1 and thiopentone 5-7 mg·kg Ϫ1 , followed by a volatile anesthetic, either enflurane or sevoflurane, with assisted ventilation by mask in groups E and S, respectively. The volatile anesthetics (enflurane or sevoflurane) were administered in 66%/33% : nitrous oxide/oxygen at the endtidal concentration corresponding to 1 minimum alveolar concentration (MAC) in the present study. One MAC of enflurane and sevoflurane was assumed to be 0.57% and 0.66% in approximately 66% nitrous oxide, respectively [13]. In group NA, anesthesia was induced with i.v. droperidol 0.2 mg · kg Ϫ1 , fentanyl 5 µg · kg Ϫ1 , and thiopentone 1-2 mg · kg Ϫ1 during inhalation of 66%/33% : N 2 O/O 2 . Stable end-tidal anesthetic concen-

show abstract

Section: Resultssupporting

confidence: 95%

Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium

Güngör

Bozkırlı

Çelebi

et al. 2003

Journal of Anesthesia

View full text Add to dashboard Cite

show abstract

“…Both groups of patients had median onset times of 4-5 min and a depth of block of 85-90% after 0.3 mg kg Ϫ1 rocuronium. These are similar to values found in previous studies [6] where mechanomyograph recordings were used. Eriksson in an Editorial in Anesthesiology has suggested that it is time that quantitative assessment of neuromuscular block be routine, or even mandatory, when non-depolarizing neuromuscular blocking agents are used [7].…”

Section: Discussionsupporting

confidence: 71%

Pharmacodynamics of rocuronium 0.3 mg kg−1 in adult patients with and without renal failure

Robertson

Driessen

Vogt

et al. 2005

European Journal of Anaesthesiology

View full text Add to dashboard Cite

show abstract

“…They concluded that intravenous anaesthetics do not appear to interact with rocuronium to a clinical significant degree. Lambalk et al [18] concluded that the influence of different anaesthetics on the time course of rocuronium was only fractional. We did not monitor neuromuscular function in our patients because of anticipated discomfort with baseline nerve stimulation in the awake state.…”

mentioning

confidence: 99%

The influence of intrathecal fentanyl on the characteristics of subarachnoid block for Caesarean section

1998

View full text Add to dashboard Cite

SummaryWe have assessed the effect of two induction agents on tracheal intubating conditions after rocuronium 0.6 mg.kg À1 in unpremedicated patients undergoing simulated rapid sequence induction. Following pre-oxygenation, anaesthesia was induced with propofol up to 2.5 mg.kg À1 (n 35) or etomidate 0.3 mg.kg À1 (n 36), and further increments as required. After loss of verbal contact, cricoid pressure was applied and rocuronium was injected. Laryngoscopy was performed at 45 s and intubation attempted at 60 s after rocuronium had been given. Ninety-four per cent of patients in the propofol group had clinically acceptable (good or excellent) intubating conditions compared to only 75% in the etomidate group (p 0.025). Owing to coughing, one patient in the etomidate group could not be intubated on the first attempt. A greater pressor response also followed intubation after induction with etomidate. We conclude that etomidate and rocuronium alone cannot be recommended for intubation at 60 s under rapid sequence induction conditions. After a period of oxygenation an intravenous barbiturate followed immediately by a full dose of muscle relaxant have long been used to permit rapid tracheal intubation in the patient at risk of aspiration [1, 2]. Thiopentone and suxamethonium are traditionally used for this purpose. Rocuronium has been shown to be a suitable alternative to suxamethonium for rapid tracheal intubation [3]. Pharyngeal and laryngeal reflexes are more depressed by propofol than by other intravenous induction agents [4] and may create more favourable intubating conditions. Propofol is increasingly being used as the induction agent of choice for rapid tracheal intubation in patients who are haemodynamically stable [5]. The main problem concerning induction of anaesthesia with propofol is dose-related hypotension and this may preclude its use in the elderly and hypovolaemic patients [6][7][8][9].Of the current induction agents, etomidate causes the least haemodynamic disturbance and may be more suitable when cardiac stability is desirable [6, 7, 10]. We were interested to see if intubating conditions and cardiovascular changes under rapid sequence induction conditions were acceptable if anaesthesia was induced with etomidate and rocuronium, rather than with propofol and rocuronium. Patients and methodAfter obtaining approval from the hospital ethics committee and informed patient consent, we studied 71 adult patients aged 18-75 years, ASA grades I and II, undergoing elective surgery. Patients with potential airway problems were not studied. No patient had hepatic or renal impairment or was receiving any medication known to interact with neuromuscular blocking agents. Patients were unpremedicated and randomly allocated to receive either propofol or etomidate after a 3-min period of preoxygenation. The estimated induction dose in the propofol group was 2.5 mg.kg À1 , and 0.3 mg.kg À1 in the etomidate group. The agent was titrated over 30 s until verbal contact was lost. Further increments were given if required. H...

show abstract

Dose‐response relationship and time course of action of Org 9426

Cited by 44 publications

References 12 publications

Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium

Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium

Pharmacodynamics of rocuronium 0.3 mg kg−1 in adult patients with and without renal failure

The influence of intrathecal fentanyl on the characteristics of subarachnoid block for Caesarean section

Contact Info

Product

Resources

About