2020
DOI: 10.1017/s0007114520000434
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Dose–response relationship between dietary choline and lipid accumulation in pyloric enterocytes of Atlantic salmon (Salmo salar L.) in seawater

Abstract: Foamy, whitish appearance of the pyloric caeca, reflecting elevated lipid content, histologically visible as hypervacuolation, is frequently observed in Atlantic salmon fed high-plant diets. Lipid malabsorption syndrome (LMS) is suggested as term for the phenomenon. Earlier studies have shown that insufficient supply of phospholipids may cause similar symptoms. The objective of the present study was to strengthen knowledge on the role of choline, the key component of phosphatidylcholine, in development of LMS … Show more

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Cited by 26 publications
(39 citation statements)
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“…Choline and PC uptake, synthesis and excretion are heavily involved in the hepatic phospholipid metabolism (63) . In the present study, increasing dietary choline did not significantly affect the phospholipid or sterol content of liver, indicating that these lipids might be tightly regulated in the liver or less responsive to dietary choline (67,68) . Unretained phospholipids and sterol were likely excreted from the liver via VLDL or bile because NEFA and TAG continued to build up with increasing dietary choline (63,69) .…”
Section: Lipid Class: Phospholipids and Sterolscontrasting
confidence: 46%
“…Choline and PC uptake, synthesis and excretion are heavily involved in the hepatic phospholipid metabolism (63) . In the present study, increasing dietary choline did not significantly affect the phospholipid or sterol content of liver, indicating that these lipids might be tightly regulated in the liver or less responsive to dietary choline (67,68) . Unretained phospholipids and sterol were likely excreted from the liver via VLDL or bile because NEFA and TAG continued to build up with increasing dietary choline (63,69) .…”
Section: Lipid Class: Phospholipids and Sterolscontrasting
confidence: 46%
“…Intestinal steatosis is a condition caused by excessive lipid accumulation within enterocytes. It represents a lipid transport disorder likely caused by deficiencies in nutrients required for the lipoprotein assembly [ 61 63 ]. Our findings, showing that several bacterial clades enriched in salmon fed the insect meal diet were negatively associated with the expression of lipid droplet marker plin2 , indicate that the intestinal microbiota might also play a role in the development of intestinal steatosis.…”
Section: Discussionmentioning
confidence: 99%
“…The observations of the above-mentioned studies suggest that dietary n-3 PL are required for the efficient export of dietary lipids from the liver and intestine [26,45,46,[73][74][75]. Besides, the dietary choline has also been shown to prevent excessive lipid accumulation in the intestine of Atlantic salmon [38].…”
Section: Effects Of Krill On Liver and Intestinal Healthmentioning
confidence: 97%
“…Choline, as part of PC, is essential for de novo synthesis of PL, betaine, and the neurotransmitter acetylcholine. Choline deficiency results in liver dysfunction in different species [38] [39,40]. Fish fed choline-deficient diets demonstrated reduced feed intake, growth, and survival [41].…”
Section: Salmo Salar (Atlantic Salmonmentioning
confidence: 99%
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