Dose–response relationship between multiple trace elements and risk of all-cause mortality: a prospective cohort study

Zhao, Shaohua; Wang, Shaohua; Yang, Xiaorong; Shen, Lin

doi:10.3389/fnut.2023.1205537

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Previous studies have proven that adequate selenium consumption promotes human health by improving metabolism, enhancing immunity, and delaying aging, which is strongly negatively correlated with all-cause mortality ( 13 , 42 , 43 ). In another study, Jenkins et al ( 44 ) indicated that supplementing selenium helps to enhance the protective effect of antioxidant mixtures on cardiovascular disease and reduce all-cause mortality.…”

Section: Discussionmentioning

confidence: 99%

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Zhang,

Meng,

et al. 2024

Front. Nutr.

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ObjectiveSelenium is an essential micronutrient and a type of dietary antioxidant. This study aimed to investigate the associations of dietary selenium intake with the risk of human chronic disease [cardiovascular disease (CVD), diabetes mellitus (DM), and cancer] and mortality among US general adults.MethodsThe dietary and demographic data in this study were collected from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Death outcomes were determined by associating with the National Death Index (NDI) records as of December 31, 2019. Logistic regression analyses were used to investigate the relationship of selenium intake with the risk of CVD, DM, and cancer. The effect of dietary selenium on all-cause and disease-specific mortality was estimated with restricted cubic spline (RCS) curves based on the univariate and multivariate Cox proportional hazard models.ResultsAmong the 25,801 participants, dietary selenium intake was divided into quintiles (Q1–Q5). After covariate adjustment, the results showed that the participants with higher quintiles (Q4 and Q5) of selenium intake tended to have a low risk of CVD (OR = 0.97, 95% CI: 0.96, 0.99; OR = 0.98, 95% CI: 0.97, 1.00, respectively). Moreover, the RCS curves showed a significant nonlinear association between selenium intake and the risk of all-cause (with a HR of 0.82, 95% CI: 0.68, 0.99) and DM-specific mortality (with the lowest HR of 0.30; 95% CI, 0.12–0.75). Furthermore, we conducted a subgroup analysis and found a negative correlation between the highest quartile of selenium intake and all-cause mortality among participants aged 50 and above (HR = 0.75, 95% CI: 0.60–0.93, p = 0.009).ConclusionOur results indicated that a moderate dietary selenium supplement decreased the risk of CVD and displayed a nonlinear trend in association with the risk of all-cause and DM-specific mortality among US adults. In addition, we found that participants aged 50 and older may benefit from higher selenium intake. However, these findings still need to be confirmed through further mechanism exploration.

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Section: Discussionmentioning

confidence: 99%

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Zhang,

Meng,

et al. 2024

Front. Nutr.

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Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults

Schöttker,

Holleczek,

Hybsier

et al. 2024

Eur J Epidemiol

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Background Selenium is an essential trace mineral. The main function of selenoprotein P (SELENOP) is to transport selenium but it has also been ascribed anti-oxidative effects. Methods To assess the association of repeated measurements of serum SELENOP concentration with all-cause and cause-specific mortality serum SELENOP was measured at baseline and 5-year follow-up in 7,186 and 4,164 participants of the ESTHER study, a German population-based cohort aged 50–74 years at baseline. Results During 17.3 years of follow-up, 2,126 study participants (30%) died. The relationship of serum SELENOP concentration with all-cause mortality was L-shaped, with mortality being significantly higher at SELENOP concentrations < 4.1 mg/L, which is near the bottom tertile’s cut-off (4.2 mg/L). All-cause mortality of participants in the bottom SELENOP tertile was significantly increased compared to subjects in the top tertile (hazard ratio [95% confidence interval]: 1.35 [1.21–1.50]). SELENOP in the bottom tertile was further associated with increased cardiovascular mortality (1.24 [1.04–1.49]), cancer mortality (1.31 [1.09–1.58]), respiratory disease mortality (2.06 [1.28–3.32]) and gastrointestinal disease mortality (2.04 [1.25–3.32]). The excess risk of all-cause mortality for those in the bottom SELENOP tertile was more than twice as strong in men as in women (interaction of SELENOP and sex; p = 0.008). Conclusions In this large cohort study, serum SELENOP concentration was inversely associated with all-cause and cause-specific mortality. Consistent inverse associations with multiple mortality outcomes might be explained by an impaired selenium transport and selenium deficiency in multiple organs. Trials testing the efficacy of selenium supplements in subjects with low baseline SELENOP concentration are needed. Trial registration Retrospectively registered in the German Clinical Trials Register on Feb 14, 2018 (ID: DRKS00014028).

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Interaction effect between blood selenium levels and stroke history on all-cause mortality: a retrospective cohort study of NHANES

Li,

Liu,

Yang

et al. 2024

Front. Neurol.

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AimThe study aimed to investigate the interaction effect between blood selenium levels and stroke history on all-cause mortality.MethodsIn this retrospective cohort study, participant data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. The covariates were screened via the backward selection method in weighted univariate and multivariate Cox regression models. Weighted univariate and multivariate Cox regression models were conducted to investigate the association of blood selenium and stroke history with all-cause mortality. The results were expressed as hazard ratios (HRs) and 95% confidence intervals (CIs). The synergy index (SI) was used to assess the assistive interaction. The association was further explored in different gender groups.ResultsTotally, 8,989 participants were included, of whom 861 (9.57%) died. Participants with blood selenium ≥192.96 ug/L were associated with lower odds of all-cause mortality (HR = 0.70, 95% CI: 0.58–0.84), whereas those with a stroke history were associated with a higher risk of all-cause mortality (HR = 1.57, 95% CI: 1.15–2.16). Compared to participants with blood selenium ≥192.96 ug/L and non-stroke history, participants with both blood selenium < 192.96 ug/L and stroke history had a higher all–cause mortality risk (HR = 2.31, 95% CI: 1.62–3.29; SI = 0.713, 95% CI: 0.533–0.952). All participants with blood selenium < 192.96 ug/L and stroke history were related to higher all–cause mortality risk (HR = 1.61, 95% CI: 1.21–2.13). In males, the interaction effect of blood selenium and stroke history on all–cause mortality (HR = 2.27, 95% CI: 1.50–3.46; SI = 0.651, 95% CI: 0.430–0.986) increased twice.ConclusionBlood selenium and stroke history have an interaction effect on all-cause mortality. Increasing selenium-rich food or supplement intake, especially for individuals with a stroke history, may improve poor prognosis.

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Dose–response relationship between multiple trace elements and risk of all-cause mortality: a prospective cohort study

Cited by 4 publications

References 40 publications

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults

Interaction effect between blood selenium levels and stroke history on all-cause mortality: a retrospective cohort study of NHANES

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