Dose-Response Relationship Between Orally Administered Ammonium Perchlorate and Urine Perchlorate Concentrations in Rats: Possible Biomarker to Quantify Environmental Ammonium Perchlorate Exposure on Thyroid Homeostasis

Chen, Hong Xia; Ding, Miao; Li, Yong Gan; Liu, Qin; Peng, Kai

doi:10.1080/19338244.2014.904265

Cited by 6 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, the accumulation of perchlorate in the milk powder and rice groups also showed a pattern of feces > urine > body, whereas the bioaccumulations in the body for these two food constituent groups were 55 and 58% lower than that in the control group, respectively. These findings are inconsistent with those from previous rat studies conducted with ammonium perchlorate aqueous solution, which have demonstrated that urinary excretion is the main pathway for elimination of perchlorate from the body. − Of note, the highest bioaccumulation of perchlorate in the pork and lettuce groups was in the urine followed by the feces and body. This finding was presumably associated with the highest moisture content occurring in pork and lettuce feeds among the investigated foods.…”

Section: Results and Discussioncontrasting

confidence: 59%

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Liu

Zhang

Yimei

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Perchlorate in various foods continuously arouses public health concern. Bioavailability is a critical parameter to better estimate perchlorate exposure from diets. In this study, perchlorate bioavailability in five foods was determined in an in vivo mouse model and compared with in vitro bioaccessibility/bioavailability. The estimated in vivo perchlorate bioavailability for different foods ranged from 18.01 ± 4.53% to 45.60 ± 7.11%, with the order lettuce > pork > rice > milk powder > soybean. Moisture, fiber, and fat in foods were identified as critical factors affecting perchlorate bioavailability (correlation r = 0.71, 0.52, and −0.67, respectively). Linear regression analysis revealed that the in vitro perchlorate bioavailability determined using the Caco-2 cell model has the potential to estimate the in vivo perchlorate bioavailability in foods (R 2 = 0.67, slope = 1.33, and y intercept = 4.99). These findings provide insights into the effects of the food matrices on perchlorate bioavailability and could contribute to decrease the uncertainty regarding perchlorate dietary exposure risk assessment.

show abstract

Section: Results and Discussioncontrasting

confidence: 59%

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Liu

Zhang

Yimei

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The dose of NaClO 4 treatment was chosen based in previous studies that evaluated the deleterious effects of chronic perchlorate exposure on thyroid function . Additionally, this dose is expressively lower than the dose used in several previous studies . Male rats were used in this study to avoid the hormone fluctuation that is usually observed in female rats (estrous cycle).…”

Section: Methodsmentioning

confidence: 99%

“…Short‐term low‐level perchlorate exposure apparently does not affect thyroid function in humans . Conversely, several studies have reported significant alterations in the thyroid axis of chronically perchlorate exposed rats, humans, amphibians, and fishes . Even so, the regulation of gene and protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats

Serrano‐Nascimento

Calil-Silveira

Dalbosco

et al. 2017

Environmental Toxicology

View full text Add to dashboard Cite

Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO in the drinking water (35 mg/Kg/day) for 60 days. Thereafter, hormone/cytokines serum levels were measured through multiplex assays; genes/proteins expression were investigated by qPCR/Western Blotting and thyroid morphology was evaluated through histological analysis. Serum TSH levels were increased and serum T /T levels were decreased in perchlorate-treated animals. This treatment also altered the thyrotropin-releasing hormone mRNA/protein content in the hypothalamus. Additionally, the expression of both subunits of TSH were increased in the pituitary of perchlorate-treated rats, which also presented significant alterations in the thyroid morphology/gene expression. Furthermore, perchlorate exposure reduced liver Dio1 mRNA expression and increased the content of pro-inflammatory cytokines in the thyroid and the serum. In conclusion, our study adds novel findings about the perchlorate-induced disruption of the hypothalamus-pituitary-thyroid axis gene/protein expression in male rats. The data presented herein also suggest that perchlorate induces thyroid and systemic inflammation through the increased production of cytokines. Taken together, our results suggest that perchlorate contamination should be monitored, especially in the individuals most susceptible to the deleterious effects of reduced levels of thyroid hormones.

show abstract

“…A dose-response sigmoid curve has been reported for describing NIS sensitivity to ClO 4 − inhibition in different species and the half maximal inhibiting concentration in humans was found at 1.566 μM [ 43 ]. To confirm these experimental results, an orally delivered acute exposure to up to 520 µg/kg of body weight (bw) induced a significant increase in serum thyroid stimulating hormone (TSH) levels, with a relevant decline in serum-free levothyroxine concentrations [ 44 ]. On the other hand, it is thought that a chronic low-dose exposure to ClO 4 − , normally observed as the consequence of food and drink intake, could impair thyroid function by reducing iodine uptake particularly in predisposed individuals, such as those with an underlying iodine deficiency [ 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food

et al. 2020

View full text Add to dashboard Cite

Background: Perchlorate-induced natrium-iodide symporter (NIS) interference is a well-recognized thyroid disrupting mechanism. It is unclear, however, whether a chronic low-dose exposure to perchlorate delivered by food and drinks may cause thyroid dysfunction in the long term. Thus, the aim of this review was to overview and summarize literature results in order to clarify this issue. Methods: Authors searched PubMed/MEDLINE, Scopus, Web of Science, institutional websites and Google until April 2020 for relevant information about the fundamental mechanism of the thyroid NIS interference induced by orally consumed perchlorate compounds and its clinical consequences. Results: Food and drinking water should be considered relevant sources of perchlorate. Despite some controversies, cross-sectional studies demonstrated that perchlorate exposure affects thyroid hormone synthesis in infants, adolescents and adults, particularly in the case of underlying thyroid diseases and iodine insufficiency. An exaggerated exposure to perchlorate during pregnancy leads to a worse neurocognitive and behavioral development outcome in infants, regardless of maternal thyroid hormone levels. Discussion and conclusion: The effects of a chronic low-dose perchlorate exposure on thyroid homeostasis remain still unclear, leading to concerns especially for highly sensitive patients. Specific studies are needed to clarify this issue, aiming to better define strategies of detection and prevention.

show abstract

Dose-Response Relationship Between Orally Administered Ammonium Perchlorate and Urine Perchlorate Concentrations in Rats: Possible Biomarker to Quantify Environmental Ammonium Perchlorate Exposure on Thyroid Homeostasis

Cited by 6 publications

References 29 publications

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food

Contact Info

Product

Resources

About