Dose-response relationship between weight loss and improvements in obstructive sleep apnea severity after a diet/lifestyle interventions: secondary analyses of the “MIMOSA” randomized clinical trial

Georgoulis, Michael; Yiannakouris, Nikos; Kechribari, Ioanna; Lamprou, Kallirroi; Perraki, Eleni; Vagiakis, Emmanοuil; Kontogianni, Meropi

doi:10.5664/jcsm.9834

Cited by 24 publications

(14 citation statements)

References 49 publications

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“…For example, weight-loss dietary/lifestyle interventions (e.g., a Mediterranean diet or a Mediterranean lifestyle, low-energy diets) can benefit weight, glycaemic and blood pressure control, and OSA severity. 49 , 50 , 51 Other relevant exposures could relate to socioeconomic status, ambient environment of noise pollution, passive smoking, and urban physical features like walkability and population density. 52 , 53 , 54 , 55 …”

Section: Discussionmentioning

confidence: 99%

Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL

et al. 2022

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“…In a clinical cohort, G eorgoulis et al . [ 28 ] found that even a <5% weight loss can reduce respiratory events, but ≥5% and ideally ≥10% weight loss was necessary for reducing the prevalence of severe OSA. Weight loss is not only associated with a decrease in AHI, but also with an improvement of hypoxaemia [ 29 ].…”

Section: Mechanical Obstructionmentioning

confidence: 99%

Current and novel treatment options for obstructive sleep apnoea

et al. 2022

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Obstructive sleep apnoea (OSA) is challenging medical problem due to its prevalence, its impact on quality of life and performance in school and profession, the implications on risk of accidents and comorbidities and mortality. Current research has carved out a broad spectrum of clinical phenotypes and defined major pathophysiological components. These findings indicate to the concept of personalised therapy, oriented on both the distinct clinical presentation and the most relevant pathophysiology in the individual patient. This leads to the question if sufficient therapeutical options other than positive airway pressure (PAP) alone are available, for which patients they may be useful, if there are specific indications for single or combined treatment, and if there is solid scientific evidence for recommendations. This review describes our knowledge on PAP and non-PAP therapies to address upper airway collapsibility, muscle responsiveness, arousability and respiratory drive. The spectrum is broad and heterogeneous, including technical and pharmaceutical options, already in clinical use or in an advanced experimental stage. Although there is an obvious need for more research on single or combined therapies, the available data demonstrate the variety of effective options, which should replace the unidirectional focus on PAP therapy.

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“…A more recent meta-analysis, of 13 randomized controlled trials and 22 uncontrolled before-and-after studies [ 24 ], showed a beneficial effect of diet-induced weight loss on OSA parameters, such as AHI, oxygen desaturation index (ODI), arousal index, and excessive daytime sleepiness (EDS). However, novel data have recently emerged [ 25 ••, 26 ••], while no systematic review has synthesized the evidence of a structured dietary program on OSA severity since then. Therefore, the aim of the study is to evaluate and summarize the existing evidence regarding the effect of different types of dietary management plans on OSA severity and symptoms.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Implementation of a Structured Diet Management Plan on the Severity of Obstructive Sleep Apnea: A Systematic Review

et al. 2022

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Purpose of Review The prevalence of obstructive sleep apnea (OSA) is increasing worldwide, in line with the increase in obesity prevalence. Taken into consideration the low compliance rates to continuous positive airway pressure (CPAP) treatment, and since obesity is a risk factor for OSA, these patients should receive additional counseling for weight loss through a diet plan. The aim of this review is to examine the role of a structured diet management plan on OSA severity, nocturnal oxygen indices, and subjective sleep parameters. Recent Findings Τhis systematic review of the literature resulted in four studies and demonstrated that severity of OSA, assessed by the apnea-hypopnea index, is reduced by a dietary management plan when delivered through an educational program. Moreover, nocturnal oxygenation is improved, as well as subjective sleep parameters, when initiating a diet on top of CPAP use. Summary In summary, the present systematic review reports on the beneficial effects of a structured diet management plan in patients with OSA. Although CPAP remains the gold standard of OSA treatment, a specific dietary plan should be sought when managing patients with OSA. Nevertheless, still the evidence is low, and further research on this field is needed to reduce the burden of OSA.

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Dose-response relationship between weight loss and improvements in obstructive sleep apnea severity after a diet/lifestyle interventions: secondary analyses of the “MIMOSA” randomized clinical trial

Cited by 24 publications

References 49 publications

Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL

Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL

Current and novel treatment options for obstructive sleep apnoea

Effect of the Implementation of a Structured Diet Management Plan on the Severity of Obstructive Sleep Apnea: A Systematic Review

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