2022
DOI: 10.1186/s12989-022-00468-9
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Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

Abstract: Background In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP) at a chemical plant suffered from lung diseases, including fibrosis, interstitial pneumonia, emphysema, and pneumothorax. We recently demonstrated that inhalation of CWAAP-A, one type of CWAAP, causes pulmonary disorders in rats. It is important to investigate dose–response relationships and recoverability from exposure to CWAAPs for establishing occupational health guidelines, such as setting thre… Show more

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Cited by 11 publications
(21 citation statements)
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“…Takeda et al and Suka et al also performed inhalation exposure and intratracheal instillation of CL‐PAA and reviewed that lung inflammation and fibrosis were observed. 16 , 17 Although the physicochemical properties of CL‐PAA are related to the potential for inflammation and fibrosis by CL‐PAA, sufficient physicochemical properties are not shown in their papers. 16 , 17 Considering that CL‐PAA induced inflammation and fibrosis in the rat lung in their studies, we speculated that the physicochemical properties of CL‐PAA used in their studies may be partially similar to those in our study.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Takeda et al and Suka et al also performed inhalation exposure and intratracheal instillation of CL‐PAA and reviewed that lung inflammation and fibrosis were observed. 16 , 17 Although the physicochemical properties of CL‐PAA are related to the potential for inflammation and fibrosis by CL‐PAA, sufficient physicochemical properties are not shown in their papers. 16 , 17 Considering that CL‐PAA induced inflammation and fibrosis in the rat lung in their studies, we speculated that the physicochemical properties of CL‐PAA used in their studies may be partially similar to those in our study.…”
Section: Discussionmentioning
confidence: 99%
“…Considering that lung damage caused by inorganic materials such as asbestos and crystalline silica can progress from persistent inflammation to irreversible fibrosis and tumors, CL‐PAA, which showed persistent inflammation by intratracheal instillation, was considered to have inflammatory and fibrotic potential in human lungs. Takeda et al and Suka et al also performed inhalation exposure and intratracheal instillation of CL‐PAA and reviewed that lung inflammation and fibrosis were observed 16,17 . Although the physicochemical properties of CL‐PAA are related to the potential for inflammation and fibrosis by CL‐PAA, sufficient physicochemical properties are not shown in their papers 16,17 .…”
Section: Discussionmentioning
confidence: 99%
“…We have previously conducted systemic inhalation exposure studies of assorted chemicals in rodents, including rasH2 mice, and have examined their toxicities, including carcinogenicity and pulmonary fibrosis 25 27 . The present study, is a 26-week systemic inhalation exposure study to 2-BP using rasH2 mice.…”
Section: Introductionmentioning
confidence: 99%
“…Several animal exposure studies using PAA have confirmed that its pathogenesis is lung disorder, as in humans [7,10,11]. Rat intratracheal instillation and inhalation exposure studies of PAA have reported neutrophilic lung inflammation, lung injury, and subsequent rapid fibrosis [7,10,11]; however, it has not yet been elucidated as to what physicochemical properties of PAA affect the physiopathology in the lung.…”
Section: Introductionmentioning
confidence: 99%