Dose–response relationships between exercise intensity, cravings, and inhibitory control in methamphetamine dependence: An ERPs study

Wang, Dongshi; Zhou, Changle; Zhao, Min; Wu, Xuesong; Chang, Yu Kai

doi:10.1016/j.drugalcdep.2016.02.023

Cited by 100 publications

(121 citation statements)

References 47 publications

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“…Similar effects of exercise have been reported in numerous recent studies conducted in men and women with other substance use disorders (18–20; for meta-analyses see 9,58). For example, acute aerobic exercise (cycling) decreased drug-craving in women and men undergoing residential treatment for methamphetamine use disorder (19), and chronic aerobic exercise (8-week treadmill interval training) decreased measures of depression in men and women undergoing residential treatment for an illicit substance use disorder (i.e., heroin, amphetamine, cannabis; 18).…”

Section: Overview Of Clinical Findingssupporting

confidence: 82%

“…Recent work has expanded this investigation to include withdrawal symptoms/craving for other drugs of abuse (9,18–20), and feasibility for relapse prevention for other substance use disorders (21–33). …”

Section: Overview Of Clinical Findingsmentioning

confidence: 99%

“…For example, acute aerobic exercise (cycling) decreased drug-craving in women and men undergoing residential treatment for methamphetamine use disorder (19), and chronic aerobic exercise (8-week treadmill interval training) decreased measures of depression in men and women undergoing residential treatment for an illicit substance use disorder (i.e., heroin, amphetamine, cannabis; 18). Recent studies have also shown that aerobic exercise during abstinence can offset deficits in inhibitory control (19–20) that have been linked to relapse (60). …”

Section: Overview Of Clinical Findingsmentioning

confidence: 99%

“…Most of the recent evidence in this regard has been provided by studies conducted in men and women with tobacco and other substance use disorders showing that exercise reduces withdrawal symptoms including craving and negative affect (7–9,12–20). Studies in male and female smokers further suggest the potential for exercise to prevent relapse and improve treatment outcomes when combined with other smoking cessation treatments (21–25).…”

Section: Introductionmentioning

confidence: 99%

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Exercise as a Sex-Specific Treatment for Substance Use Disorder

et al. 2017

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Purpose of Review Exercise is a promising treatment for substance use disorder that may reduce withdrawal symptoms and prevent relapse. In this review, we discuss recent evidence from clinical and preclinical studies for its efficacy, from a behavioral to a molecular level, in order to understand the exercise conditions that lead to beneficial effects. We also highlight the few recent findings of sex-specific differences. Recent Findings Clinical and preclinical findings show that exercise decreases withdrawal symptoms, including craving, in both males and females. Evidence from clinical studies support the efficacy of exercise to prevent relapse to smoking, although further research is needed to examine sex differences, establish long-term efficacy, and to determine if effects extend to other substance use disorders. Preclinical findings also support the potential utility of exercise to prevent relapse with evidence suggesting that its efficacy is enhanced in males, and mediated by blocking drug-induced adaptations that occur during early abstinence. Summary Sex differences and timing of exercise availability during abstinence should be considered in future studies examining exercise as an intervention for relapse. A better understanding of the neurobiological mechanisms underlying the efficacy of exercise to reduce withdrawal symptoms and prevent relapse is needed to guide its development as a sex-specific treatment.

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Section: Overview Of Clinical Findingssupporting

confidence: 82%

Section: Overview Of Clinical Findingsmentioning

confidence: 99%

Section: Overview Of Clinical Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exercise as a Sex-Specific Treatment for Substance Use Disorder

et al. 2017

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“…In this analysis, the subject showed enhanced PFC activity during the Stroop test, as well as improved performance on the cognitive test (see Figure 2). Previous studies have shown that patients with substance use disorder usually exhibit decreased inhibitory response on the Stroop test (Hillman & Drobes, 2012), and that an acute session of aerobic exercise improves the performance on inhibitory control associated with greater activity on electrophysiological records of the PFC (Wang, Zhou, Zhao, Wu, & Chang, 2016). Interestingly, exercise has been related to increased levels of brain-derived neurotrophic factor, which plays an important role on several molecular changes that might enhance cognitive functions (Monnier et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

The Benefits of High Intensity Exercise on the Brain of a Drug Abuser

Cabral¹,

Tavares²,

Costa³

et al. 2018

GJHS

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Chronic drug abuse has been shown to cause dysfunctions on the frontal lobe and affect cognition, cardiac autonomic control and psychosocial aspects. Despite physical exercise has been shown to improve cerebral functioning, the effects of a high intensity exercise training program needs to be further explored in a drug abuse condition. The patient was a 32-year-old male who has been an alcohol and crack/cocaine user for 20 years. The high intensity exercise training protocol consisted of four 30-second "all-out" bouts performed three times per week during four weeks. The participant had electroencephalographic (EEG) activity, cognition, cardiac autonomic control and psychosocial questionnaires evaluated before and after high intensity exercise training. Prefrontal cortex (PFC) oxygenation during an incremental running exercise test was also recorded. EEG topographical analysis revealed greater PFC activation during the cognitive test. Performance on the cognitive test was enhanced (l number of total errors and reaction time). Parasympathetic cardiac indices, including RMSSD, SDNN, Pnn50% and HF power increased by 77.4%, 83.3%, 57.7% and 293.2%, respectively. Sleep quality increased 23% and anxiety levels decreased 52.6%. Psychological and social domains increased 5.3% and 13.7%, respectively. In addition, incremental treadmill running time increased 12.5% and PFC oxyhemoglobin increased 228.2% at the beginning of the treadmill test, 305.4% at the middle and 359.4% at the end of the test. Thus, high intensity exercise training improved PFC functioning, cardiac autonomic control and psychological parameters. These results might indicate high intensity exercise as an alternative and non-pharmacological tool to help the rehabilitation of a drug abuser.

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Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

2020

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In the wake of the opioid crisis, methamphetamine has reemerged as a challenge to mental health clinicians and researchers alike. Methamphetamine is now available in different forms such as ice, powder, and pills, with different pharmacokinetic characteristics that make them popular among certain types of individuals. 1 Recent seizure data suggest that methamphetamine production and trafficking are spreading into new areas of the globe. 2 According to the Automation of Reports and Consolidated Orders System, methamphetamine consumption increased 4-fold between 2015 and 2016 and total stimulant use doubled in the last decade. 3 From 2011 through 2016, the age-adjusted rate of drug overdose deaths involving methamphetamine more than tripled. 4 Moreover, drug overdose deaths involving cocaine, amphetamines, or both substances combined increased 42.4% from 12 122 in 2015 to 17 258 in 2016. 5 Based on the most recent data from the National Survey on Drug Use and Health, 6 the 12-month prevalence of individuals aged 12 years or older reporting methamphetamine use has increased by 195% from its low in 2010 to 2018 (Figure 1), and it is estimated that 1.86 million Americans used methamphetamine in 2018. These numbers underline the importance of paying attention to the possibility of the next substance use crisis. However, whereas opioid use disorder can be treated pharmacologically 7 and behaviorally, 8 there are significant challenges for the treatment of methamphetamine use disorder (MUD). This review focuses on 3 specific aspects of MUD. First, the neurobiology of methamphetamine is more complex than the traditional view of it as a monoaminergic modulator. Second, the clinical presentation is not limited to the symptoms associated with use disorder but extend to medical presentations, most notably the cardiovascular and cerebrovascular systems. Third, pharmacologic interventions focused on modulating the monoaminergic pathways have largely failed, and new pharmacologic approaches are necessary to focus on novel treatment targets. In the final section, several suggestions will be proposed for both clinicians and researchers to advance the understanding of MUD. Biological Pathways, Neural Basis, and CognitionMethamphetamine has been conceptualized primarily as a releaser of dopamine, serotonin, noradrenaline, and adrenaline from nerve terminals in the central and peripheral nervous system, 9 which occurs via several different mechanisms, including (1) redistributing catecholamines from synaptic vesicles to the cytosol, (2) reversing the plasma membrane transport of neurotransmitters, (3) blocking the activity of monoamine transporters, (4) decreasing the expression of dopamine transporters at the cell surface, (5) inhibiting monoamine oxidase activity, and (6) increasing the activity and IMPORTANCE The prevalence of and mortality associated with methamphetamine use has doubled during the past 10 years. There is evidence suggesting that methamphetamine use disorder could be the next substance use crisis in the United ...

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Dose–response relationships between exercise intensity, cravings, and inhibitory control in methamphetamine dependence: An ERPs study

Cited by 100 publications

References 47 publications

Exercise as a Sex-Specific Treatment for Substance Use Disorder

Exercise as a Sex-Specific Treatment for Substance Use Disorder

The Benefits of High Intensity Exercise on the Brain of a Drug Abuser

Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

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