Dose-volume Analysis of Predictors for Gastrointestinal Toxicity after Radiotherapy and Concurrent Full-dose Gemcitabine for Locally Advanced Pancreatic Adenocarcinoma

Stomach Dose–Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer

“…It is worth noting that in our analysis we failed to show associations of GI toxicity with duodenum dose-volume, despite other studies having shown evidence of a relationship [29]. Murphy et al showed a trend for association of increased duodenal dose-olu e ith g ade ≥ GI to i it i patie ts t eated ith o o ita t gemcitabine [7], but Huang et al found the best predictor of toxicity in similar patients was the duodenum V35Gy (V25Gy when including patients who received concomitant erlotinib) [9]. Kelly et al have examined the largest cohort in this group, and found duodenum V55Gy the best predictor of risk [5].…”

“…Clinical data on the radiotherapy tolerances for the stomach and duodenum remain sparse, but some studies have confirmed the association between organ-at-risk (OAR) radiotherapy parameters and subsequent risk of toxicity [5,[7][8][9][10][11][12].…”

Dosimetric benefits of dynamic wave arc over co-planar volumetric modulated radiotherapy for locally advanced pancreatic cancer

“…Clinical trials assessing the bene ts of escalated dose radiation with an IMRT technique in LAPC have shown signi cantly increased local control and OS [6,15] Previous reports have showed the association between DVIs and GI toxicities, but the prescribed doses and fractionations varied among these reports (Table 4) [16][17][18][19]. The BED is commonly used to compare such various doses and fractionation schedules with an alpha/beta ratio of 10 Gy (BED10) for acute toxicities and 3 Gy (BED3) for late toxicities in the duodenum.…”

Dosimetric analysis of upper gastrointestinal ulcer after carbon-ion radiotherapy for pancreatic cancer

“…The incidence of severe upper GI ulcer or hemorrhage after CRT for pancreatic cancer was reported as approximately 10-30% [10][11][12][13]. In most studies, an endoscopic examination was performed in patients with symptoms, so that the incidence might have been underestimated [14].…”