DoseMRT: A Software Package for Individualised Monte Carlo Dose Calculations of Synchrotron-Generated Microbeam Radiation Therapy

Paino, Jason; Cameron, Matthew; Large, Matthew J.; Barnes, Micah; Engels, Elette; Vogel, Sarah; Tehei, Moeava; Corde, Stéphanie; Guatelli, Susanna; Rosenfeld, Anatoly; Lerch, Michael L. F

doi:10.3390/radiation3020011

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…The high-resolution mode delivers a uniform field of n cm , while the latter provides a n cm beam particularly suitable for phase contrast imaging 36 . Monte Carlo simulations were performed using Geant4 version 10.07 patch 2, which we chose in this work due to its open-source licensing, the ease with which the physics models in the code can be manually modified, and the extensive institutional expertise at ANSTO and the University of Wollongong with this toolkit 37 – 40 . Geant4 has previously been used for many similar projects, including neutron transport as well as the design of the neutron beam and beamline components 41 – 43 .…”

Section: Methodsmentioning

confidence: 99%

A Monte Carlo model of the Dingo thermal neutron imaging beamline

Jakubowski,

Chacon,

Tran

et al. 2023

Sci Rep

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In this study, we present a validated Geant4 Monte Carlo simulation model of the Dingo thermal neutron imaging beamline at the Australian Centre for Neutron Scattering. The model, constructed using CAD drawings of the entire beam transport path and shielding structures, is designed to precisely predict the in-beam neutron field at the position at the sample irradiation stage. The model’s performance was assessed by comparing simulation results to various experimental measurements, including planar thermal neutron distribution obtained in-beam using gold foil activation and $$^{10}$$ 10 B$$_{4}$$ 4 C-coated microdosimeters and the out-of-beam neutron spectra measured with Bonner spheres. The simulation results demonstrated that the predicted neutron fluence at the field’s centre is within 8.1% and 2.1% of the gold foil and $$^{10}$$ 10 B$$_{4}$$ 4 C-coated microdosimeter measurements, respectively. The logarithms of the ratios of average simulated to experimental fluences in the thermal (E$$_{th}<$$ th < 0.414 eV), epithermal (0.414 eV < E$$_{epi}<$$ epi < 11.7 keV) and fast (E$$_{fast}>$$ fast > 11.7 keV) spectral regions were approximately − 0.03 to + 0.1, − 0.2 to + 0.15, and − 0.4 to + 0.2, respectively. Furthermore, the predicted thermal, epithermal and fast neutron components in-beam at the sample stage position constituted approximately 18%, 64% and 18% of the total neutron fluence.

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Section: Methodsmentioning

confidence: 99%

A Monte Carlo model of the Dingo thermal neutron imaging beamline

Jakubowski,

Chacon,

Tran

et al. 2023

Sci Rep

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Minibeam Radiation Therapy Treatment (MBRT): Commissioning and First Clinical Implementation

Grams,

Mateus,

Mashayekhi

et al. 2024

International Journal of Radiation Oncology*Biology*Physics

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Comparison of X-Ray Absorption in Mandibular Tissues and Tissue-Equivalent Polymeric Materials Using PHITS Monte Carlo Simulations

Gokcekuyu,

Ekinci,

Buyuksungur

et al. 2024

Applied Sciences

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This study investigates the absorption of X-rays in mandibular tissues by comparing real tissues with tissue-equivalent materials using the PHITS Monte Carlo simulation program. The simulation was conducted over a range of X-ray photon energies from 50 to 100 keV, with increments of 5 keV, to evaluate the dose absorbed by different tissues. Real tissues, such as the skin, parotid gland, and masseter muscle, were compared with their tissue-equivalent polymeric materials, including PMMA, Parylene N, and Teflon. The results showed that the real tissues generally absorbed more X-rays than their corresponding equivalents, especially at lower energy levels. For instance, at 50 keV, differences in the absorbed doses reached up to 50% for the masseter muscle and its equivalent, while this gap narrowed at higher energies. The study highlights the limitations of current tissue-equivalent materials in accurately simulating real tissue behavior, particularly in low-energy X-ray applications. These discrepancies suggest that utilizing tissue-equivalent materials may lead to less accurate medical imaging and radiotherapy dose calculations. Future research should focus on improving tissue-equivalent materials and validating simulation results with experimental data to ensure more reliable dosimetric outcomes. This study provides a foundation for refining radiation dose calculations and improving patient safety in clinical applications involving X-rays.

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DoseMRT: A Software Package for Individualised Monte Carlo Dose Calculations of Synchrotron-Generated Microbeam Radiation Therapy

Cited by 3 publications

References 33 publications

A Monte Carlo model of the Dingo thermal neutron imaging beamline

A Monte Carlo model of the Dingo thermal neutron imaging beamline

Minibeam Radiation Therapy Treatment (MBRT): Commissioning and First Clinical Implementation

Comparison of X-Ray Absorption in Mandibular Tissues and Tissue-Equivalent Polymeric Materials Using PHITS Monte Carlo Simulations

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