Doses to Systemic Tissues from Radon Gas

Alam, Khursheed

doi:10.1093/oxfordjournals.rpd.a033035

Cited by 64 publications

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“…[16][17][18] The change in the activity concentration (C i ) of radon in the i th compartment per time (t) is given by…”

Section: Pbpk Model Structurementioning

confidence: 99%

“…These are two kinds of values 16,17) optimized on the basis of the work of Nussbaum and Hursh. 25) In the present study, both coefficients were individually applied for the calculation.…”

Section: Physicochemical Parametermentioning

confidence: 99%

“…16) For the purpose of accuracy, the self-absorption of alpha particle energies within the fat cells must also be taken into consideration. The simplification made in the present work, which is that the red bone marrow Solid and dashed lines represent our PBPK calculations using the partition coefficients of radon given by Khusheed 16) and NRC, 17) respectively. The radon concentration was calculated using two different partition coefficients reported by Khursheed 16) and NRC, 17) as presented in Table 3.…”

Section: )mentioning

confidence: 99%

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Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans

Sakoda

Ishimori

Kawabe

et al. 2010

Journal of Nuclear Science and Technology

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This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses to organs and tissues in mice, rats, and humans, we computed the behavior of inhaled radon in their bodies on the basis of a physiologically based pharmacokinetic (PBPK) model. It was assumed that radon dissolved in blood entering the gas exchange compartment is transported to any tissue by the blood circulation to be instantaneously distributed according to a tissue/blood partition coefficient. The calculated concentrations of radon in the adipose tissue and red bone marrow following its inhalation were much higher than those in the others, because of the higher partition coefficients. Compared with a previous experimental data for rats and model calculation for humans, the present calculation was proved to be valid. Absorbed dose rates to organs and tissues were estimated to be within the range of 0.04-1.4 nGy (Bq m À3 ) À1 day À1 for all the species. Although the dose rates are not so high, it may be better to pay attention to the dose to the red bone marrow from the perspective of radiation protection. For more accurate dose assessment, it is necessary to update tissue/blood partition coefficients of radon that strongly govern the result of the PBPK modeling.

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“…[16][17][18] The change in the activity concentration (C i ) of radon in the i th compartment per time (t) is given by…”

Section: Pbpk Model Structurementioning

confidence: 99%

“…These are two kinds of values 16,17) optimized on the basis of the work of Nussbaum and Hursh. 25) In the present study, both coefficients were individually applied for the calculation.…”

Section: Physicochemical Parametermentioning

confidence: 99%

Section: )mentioning

confidence: 99%

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Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans

Sakoda

Ishimori

Kawabe

et al. 2010

Journal of Nuclear Science and Technology

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“…De plus, une fraction du gaz radon entre dans la circulation sanguine et traverse le foie avant de se répartir dans les différents tissus, avec une affinité particulière pour la graisse, ou d'être exhalée via le poumon (Khursheed, 2000 ;NRC, 1999). En conséquence les tissus les plus irradiés après la paroi de l'estomac sont ceux qui contiennent une fraction adipeuse significative : moelle osseuse incluant les cellules souches hématopoïétiques et les cellules précurseurs de l'os ; ceux qui sont fortement vascularisés : foie, rein, cerveau ; et ceux qui se trouvent sur les voies d'épuration du gaz : intestin grêle, colon et poumon (NRC, 1999).…”

Section: Dosimétrie Du Radon Ingéré Avec L'eau De Boissonunclassified

Conséquences dosimétriques et sanitaires de l’ingestion de radonvial’eau de boisson

2010

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RÉSUMÉSi le risque de cancer du poumon lié à l'inhalation de radon est aujourd'hui largement reconnu, les possibles conséquences sanitaires de l'ingestion d'eau contenant du radon apparaissent moins bien documentées. Cet article synthétise les connaissances actuelles sur la dosimétrie correspondant à l'ingestion de radon. Les résultats des études épidémiologiques sur les effets sanitaires du radon dans l'eau de boisson sont également présentés et discutés. ABSTRACT Dosimetric and health consequences of radon ingestion via drinking water.Lung cancer risk following radon inhalation is strongly established. On the contrary, much less is known about the possible health effects of radon ingestion via drinking water. This article summarizes the current knowledge of dosimetry following radon ingestion. Results from epidemiological studies of radon in drinking water are also presented and discussed.

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“…Elle n'est donc pas calculée ici. Cependant, l'étude de Khursheed (2000) suggère que sa contribution à l'exposition interne globale dans les scénarios étudiés peut être négligée.…”

Section: Calcul De La Dose Par Exposition Interneunclassified

Évaluations dosimétriques de l’exposition potentielle liée à l’accumulation naturelle d’uranium et de thorium dans les sables de certaines plages du littoral de Camargue

et al. 2008

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Doses to Systemic Tissues from Radon Gas

Cited by 64 publications

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Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans

Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans

Conséquences dosimétriques et sanitaires de l’ingestion de radonvial’eau de boisson

Évaluations dosimétriques de l’exposition potentielle liée à l’accumulation naturelle d’uranium et de thorium dans les sables de certaines plages du littoral de Camargue

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