Background: Myofunctional therapy has been shown to be effective in treating sleep-disordered breathing. The elaboration of this protocol arises with the purpose of establishing a complete and common evaluation of sleep respiratory disorders from the point of view of the anatomy and functionality of the upper airway to guarantee the long-term treatment of the different phenotypes of patients with obstructive sleep apnoea (OSA). Our multidisciplinary unit has an experience of more than 10 years in treating OSA patients and has numerous recent publications focused on the role of myofunctional therapy. Methods: The evaluation of the patient with obstructive sleep apnoea is carried out jointly by the medical team of Pulmonology and Otorhinolaryngology of the Sleep Unit. The patients undergo an anatomical and motor tone evaluation of the upper airway to find the cause of the collapse and a sleep study to confirm the diagnosis and its severity. Conclusions: With this protocol we want to present our clinical experience in the comprehensive diagnostic management of the patient with obstructive sleep apnea and provide the most correct treatment among the different therapeutic options available for sleep apnea.