Dosimetric Assessment of a High Precision System for Mouse Proton Irradiation to Assess Spinal Cord Toxicity

Howard, Michelle E.; Denbeigh, Janet M.; Debrot, Emily; García, Darwin Alexis Cruz; Remmes, Nicholas B.; Herman, Michael; Beltran, Chris

doi:10.1667/rade-20-00153.1

Cited by 4 publications

(1 citation statement)

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“…Here, precise and reproducible positioning is key, especially for 3D targets inside the animal body. Elaborated positioning for animal experiments is realized at the different proton centers [31,[42][43][44][45][46][47][48], which is, however, difficult to standardize. In a first attempt, Gerlach et al developed a portable setup for animal studies with protons [46]; some facilities installed small animal irradiators, enabling in situ CT imaging and precise positioning of target volumes [49,50].…”

Section: The Physicist's Point Of Viewmentioning

confidence: 99%

Models for Translational Proton Radiobiology—From Bench to Bedside and Back

Suckert

Nexhipi

Dietrich

et al. 2021

Cancers

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The number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call for basic and translational preclinical research. Open issues are the on-going discussion on an energy-dependent varying proton RBE (relative biological effectiveness), a better characterization of normal tissue side effects and combination treatments with drugs originally developed for photon therapy. At the same time, novel possibilities arise, such as radioimmunotherapy, and new proton therapy schemata, such as FLASH irradiation and proton mini-beams. The study of those aspects demands for radiobiological models at different stages along the translational chain, allowing the investigation of mechanisms from the molecular level to whole organisms. Focusing on the challenges and specifics of proton research, this review summarizes the different available models, ranging from in vitro systems to animal studies of increasing complexity as well as complementing in silico approaches.

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