Dosimetric comparison of Acuros TM BV with AAPM TG43 dose calculation formalism in breast interstitial high-dose-rate brachytherapy with the use of metal catheters

Sinnatamby, Mourougan; Nagarajan, Vivekanandan; Reddy, Sathyanarayana; Karunanidhi, Gunaseelan; Singhavajala, Vivekanandam

doi:10.5114/jcb.2015.54052

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…These ranges are in agreement with a 5-10% difference for skin point doses at different distances from the breast center, calculated with TG-43 and Monte Carlo simulations [ 4 ]. The difference of D max of lung and ribs has been previously reported for TG-43- and Acuros-based calculations of interstitial implants with metal catheters [ 15 ]. Reported results seem to indicate a ~2% larger impact of metal catheters on the differences in D max in comparison to the present results for plastic catheters.…”

Section: Discussionmentioning

confidence: 70%

Impact of heterogeneity-corrected dose calculation using a grid-based Boltzmann solver on breast and cervix cancer brachytherapy

Hofbauer

Kirisits

Resch

et al. 2016

jcb

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PurposeTo analyze the impact of heterogeneity-corrected dose calculation on dosimetric quality parameters in gynecological and breast brachytherapy using Acuros, a grid-based Boltzmann equation solver (GBBS), and to evaluate the shielding effects of different cervix brachytherapy applicators.Material and methodsCalculations with TG-43 and Acuros were based on computed tomography (CT) retrospectively, for 10 cases of accelerated partial breast irradiation and 9 cervix cancer cases treated with tandem-ring applicators. Phantom CT-scans of different applicators (plastic and titanium) were acquired. For breast cases the V20Gyαβ3 to lung, the D0.1cm3, D1cm3, D2cm3 to rib, the D0.1cm3, D1cm3, D10cm3 to skin, and Dmax for all structures were reported. For cervix cases, the D0.1cm3, D2cm3 to bladder, rectum and sigmoid, and the D50, D90, D98, V100 for the CTVHR were reported. For the phantom study, surrogates for target and organ at risk were created for a similar dose volume histogram (DVH) analysis. Absorbed dose and equivalent dose to 2 Gy fractionation (EQD2) were used for comparison.ResultsCalculations with TG-43 overestimated the dose for all dosimetric indices investigated. For breast, a decrease of ~8% was found for D10cm3 to the skin and 5% for D2cm3 to rib, resulting in a difference ~ –1.5 Gy EQD2 for overall treatment. Smaller effects were found for cervix cases with the plastic applicator, with up to –2% (–0.2 Gy EQD2) per fraction for organs at risk and –0.5% (–0.3 Gy EQD2) per fraction for CTVHR. The shielding effect of the titanium applicator resulted in a decrease of 2% for D2cm3 to the organ at risk versus 0.7% for plastic.ConclusionsLower doses were reported when calculating with Acuros compared to TG-43. Differences in dose parameters were larger in breast cases. A lower impact on clinical dose parameters was found for the cervix cases. Applicator material causes systematic shielding effects that can be taken into account.

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Section: Discussionmentioning

confidence: 70%

Impact of heterogeneity-corrected dose calculation using a grid-based Boltzmann solver on breast and cervix cancer brachytherapy

Hofbauer

Kirisits

Resch

et al. 2016

jcb

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“…Comparison of GBBS and TG-43 for- malism on breast interstitial metal catheters shows that the estimated dose to CTV was only marginally different from the two systems. There is a significant difference in estimated doses, ranging from 4% to 53% in the mean value of all parameters analyzed [16]. However, this uncertainty in HDR brachytherapy dose calculation is much more considerable than that observed in external beam dose calculations in the current clinical practice.…”

Section: Discussionmentioning

confidence: 91%

Impact of GBBS algorithm on post-mastectomy scar boost irradiation of breast using catheter flap

Sinnatamby¹,

Neelakandan²,

Karunanidhi³

et al. 2021

jcb

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Purpose: Post-mastectomy radiation therapy significantly reduces locoregional recurrence rates, which can be achieved with external beam radiotherapy delivered to chest wall, followed by scar irradiation either by electron or high-dose-rate (HDR) mould brachytherapy. The present study evaluates dosimetric advantage of Acuros ® BV, a TG-186 MBDCA, over TG-43 formalism using 192 Ir source for HDR brachytherapy in chest wall scar boost using catheter flap.Material and methods: A total of 25 patients, free of cardiac and pulmonary co-morbidities, who met the inclusion criteria were involved in the study. Catheter flap made of silicon with 20 channels was used to deliver a total dose of 7.5 Gy/3 fx by HDR surface mould brachytherapy to delineated scar volume. Plan was optimized with iterative method to obtain desired results with TG-43 formalism, followed by Acuros ® BV (GBBS algorithm) without altering dwell positions or time. The two algorithm plans were analyzed qualitatively and quantitatively with dose-volume histograms.Results: The mean D 98% CTV-HDR_evl coverage decreased by 1.16% compared to TG-43, and near-maximum dose decreased by 8.18% (p = 0.000), mean D max dose to CTV-HDR_evl, and mean D mean dose was lesser by 6.25% (p = 0.000) and 10.82% (p = 0.000), respectively, compared to TG-43. Heart D 2% showed significant results, whereas D median (cGy) revealed very significant difference. A 5 mm thick skin contour showed statistically significant results (p = 0.000) for V 150% and V 200% .Conclusions: The presented data showed how Acuros ® BV, algorithm-based calculation in scar boost irradiation of breast, accounting for a mass density of the medium and scatter condition, considered actual dose prediction in a medium.

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“…Given the geometric uncertainties, it was postulated to consider all cardiac dose parameters including V 4Gy and V 25Gy , along with MHD, when assessing the risk of future cardiac morbidity [ 18 ]. For interstitial BT with the use of both metal and plastic catheters, the planning system applied was demonstrated to influence the dose to various volumes of interest [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Radiation dose to the left anterior descending coronary artery during interstitial pulsed-dose-rate brachytherapy used as a boost in breast cancer patients undergoing organ-sparing treatment

Sinacki

Serkies

Dziadziuszko

et al. 2017

jcb

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PurposeTo assess dose received by the left anterior descending (LAD) coronary artery during interstitial pulsed-dose-rate brachytherapy (PDR-BT) boost for left-sided breast cancer patients undergoing organ-sparing treatment.Material and methodsThirty consecutive pT1-3N0-1M0 breast cancer patients boosted between 2014 and 2015 with 10 Gy/10 pulses/hour PDR-BT following a computed tomography (CT) simulation with the multi-catheter implant were included. The most common localization of primary tumor were upper quadrants. Patients were implanted with rigid tubes following breast conserving surgery and whole breast external beam irradiation (40 Gy/15 or 50 Gy/25 fractions). Computed tomography scans were retrospectively reviewed and LADs were contoured without and with margin of 5 mm (LAD5mm). Standard treatment plan encompassed tumor bed determined by the surgical clips with margin of 2 cm. Dosimetric parameters were extracted from the dose-volume histograms.ResultsThe mean D90 and V100 were 10.3 Gy (range: 6.6-13.3), and 42.0 cc (range: 15.3-109.3), respectively. The median dose non-uniformity ratio (DNR) was 0.50 (range: 0.27-0.82). The mean doses to LAD and LAD5mm were 1.0 Gy and 0.96 Gy, and maximal doses were 1.57 Gy and 1.99 Gy, respectively. Dose to the 0.1 cc of the LAD and LAD5mm were 1.42 Gy and 1.85 Gy (range: 0.01-4.98 Gy and 0.1-6.89 Gy), respectively.ConclusionsInterstitial multi-catheter PDR-BT used as a boost for left-sided breast cancer is generally associated with low dose to the LAD. However, higher dose in individual cases may require alternative approaches.

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Dosimetric comparison of Acuros TM BV with AAPM TG43 dose calculation formalism in breast interstitial high-dose-rate brachytherapy with the use of metal catheters

Cited by 12 publications

References 21 publications

Impact of heterogeneity-corrected dose calculation using a grid-based Boltzmann solver on breast and cervix cancer brachytherapy

Impact of heterogeneity-corrected dose calculation using a grid-based Boltzmann solver on breast and cervix cancer brachytherapy

Impact of GBBS algorithm on post-mastectomy scar boost irradiation of breast using catheter flap

Radiation dose to the left anterior descending coronary artery during interstitial pulsed-dose-rate brachytherapy used as a boost in breast cancer patients undergoing organ-sparing treatment

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