Dosimetric comparison of stopping power calibration with dual‐energy CT and single‐energy CT in proton therapy treatment planning

Zhu, Jiahua; Penfold, Scott

doi:10.1118/1.4948683

Cited by 64 publications

(95 citation statements)

References 35 publications

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“…Due to comparable dose differences in the polymer and the anthropomorphic phantom, the authors transferred the results derived from the reference Catphan phantom to the Rando phantom for which a reference SPR dataset was not available (Section 3.D.). Based on these evaluations, the authors suggest clinical applicability and improved SPR accuracy of DECT for clinical treatment plans (“This suggests that the results obtained with the Catphan are a reasonable representation of potential advantages of DECT over SECT‐based clinical IMPT treatment planning”, last sentence in discussion).…”

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confidence: 98%

“…A dosimetric comparison of proton treatment planning based on single‐energy CT (SECT) and dual‐energy CT (DECT) was recently published by Zhu and Penfold in Medical Physics . In this study, the polymer phantom Catphan Module 404 (The Phantom Laboratory, Salem, NY, USA) of known material composition was used to demonstrate an improved accuracy of dose calculation using DECT instead of SECT.…”

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confidence: 99%

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Comment on: Dosimetric comparison of stopping‐power calibration with dual‐energy CT and single‐energy CT in proton therapy treatment planning [Med. Phys. 43(6), 2845‐2854 (2016)]

et al. 2017

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confidence: 98%

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confidence: 99%

Comment on: Dosimetric comparison of stopping‐power calibration with dual‐energy CT and single‐energy CT in proton therapy treatment planning [Med. Phys. 43(6), 2845‐2854 (2016)]

et al. 2017

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“…In fact recent publications are showing promise for proton beam range calculation uncertainties to be in the order of 1% error with the use of dual energy CT (DECT). 35,36,37 A potential initial workflow in MRPT would then be to register daily MR images back to the original planning CT dataset. This would accurately account for any patient anatomy changes, provided that there is confidence in the deformable image registration process for the given anatomical site.…”

Section: A Mri-only Proton Therapy Planningmentioning

confidence: 99%

Future of medical physics: Real‐time MRI‐guided proton therapy

et al. 2017

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With the recent clinical implementation of real-time MRI-guided x-ray beam therapy (MRXT), attention is turning to the concept of combining real-time MRI guidance with proton beam therapy; MRIguided proton beam therapy (MRPT). MRI guidance for proton beam therapy is expected to offer a compelling improvement to the current treatment workflow which is warranted arguably more than for x-ray beam therapy. This argument is born out of the fact that proton therapy toxicity outcomes are similar to that of the most advanced IMRT treatments, despite being a fundamentally superior particle for cancer treatment. In this Future of Medical Physics article, we describe the various software and hardware aspects of potential MRPT systems and the corresponding treatment workflow. Significant software developments, particularly focused around adaptive MRI-based planning will be required. The magnetic interaction between the MRI and the proton beamline components will be a key area of focus. For example, the modeling and potential redesign of a magnetically compatible gantry to allow for beam delivery from multiple angles towards a patient located within the bore of an MRI scanner. Further to this, the accuracy of pencil beam scanning and beam monitoring in the presence of an MRI fringe field will require modeling, testing, and potential further development to ensure that the highly targeted radiotherapy is maintained. Looking forward we envisage a clear and accelerated path for hardware development, leveraging from lessons learnt from MRXT development. Within few years, simple prototype systems will likely exist, and in a decade, we could envisage coupled systems with integrated gantries. Such milestones will be key in the development of a more efficient, more accurate, and more successful form of proton beam therapy for many common cancer sites.

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“…They confirmed a higher accuracy for DECT in their surrogate patients using a pencil beam algorithm. Zhu et al confirmed in a phantom the dosimetric advantages in proton therapy treatment planning with DECT over the current approach based on SECT [85]. Whether this is clinically relevant needs to be investigated in future.…”

Section: Applicationsmentioning

confidence: 99%

Dual-Energy CT in Head and Neck Imaging

et al. 2017

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Purpose of ReviewTo explain the technique of Dual-energy CT (DECT) and highlight its applications and advantages in head and neck radiology.Recent FindingsUsing DECT, additional datasets can be created next to conventional images. In head and neck radiology, three material decomposition algorithms can be used for improved lesion detection and delineation of the tumor. Iodine concentration measurements can aid in differentiating malignant from nonmalignant lymph nodes and benign posttreatment changes from tumor recurrence. Virtual non-calcium images can be used for detection of bone marrow edema. Virtual mono-energetic imaging can be useful for improved iodine conspicuity at lower keV and for reduction of metallic artifacts and increase in signal-to-noise ratio at higher keV.SummaryDECT and its additional reconstructions can play an important role in head and neck cancer patients, from initial diagnosis and staging, to therapy planning, evaluation of treatment response and follow-up. Moreover, it can be helpful in imaging of infections and inflammation and parathyroid imaging as supplementary reconstructions can be obtained at lower or equal radiation dose compared with conventional single energy scanning.

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Dosimetric comparison of stopping power calibration with dual‐energy CT and single‐energy CT in proton therapy treatment planning

Cited by 64 publications

References 35 publications

Comment on: Dosimetric comparison of stopping‐power calibration with dual‐energy CT and single‐energy CT in proton therapy treatment planning [Med. Phys. 43(6), 2845‐2854 (2016)]

Comment on: Dosimetric comparison of stopping‐power calibration with dual‐energy CT and single‐energy CT in proton therapy treatment planning [Med. Phys. 43(6), 2845‐2854 (2016)]

Future of medical physics: Real‐time MRI‐guided proton therapy

Dual-Energy CT in Head and Neck Imaging

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