Dosimetric Impact and Theoretical Clinical Benefits of Fiducial Markers for Dose Escalated Prostate Cancer Radiation Treatment

Gauthier, Isabelle; Carrier, Jean‐François; Béliveau-Nadeau, D.; Fortin, B.; Taussky, Daniel

doi:10.1016/j.ijrobp.2008.09.043

Cited by 28 publications

(16 citation statements)

References 43 publications

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“…Fiducial markers have been traditionally used as a part of image-guided radiotherapy in the management of prostate cancer and, more recently, lung and gastrointestinal tumors (10,11). Fiducial markers have been shown to improve verification of organ position at the time of radiation delivery, leading to a reduction in setup error and therefore allowing for a reduction in margin expansion for the PTV.…”

Section: Discussionmentioning

confidence: 99%

Improvement in Interobserver Accuracy in Delineation of the Lumpectomy Cavity Using Fiducial Markers

Shaikh

Chen

Khan

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 99%

Improvement in Interobserver Accuracy in Delineation of the Lumpectomy Cavity Using Fiducial Markers

Shaikh

Chen

Khan

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…[9][10][11] Such markers can improve treatment through optimized planning, tumor positioning accuracy, and tumor tracking resulting in more precise dose delivery and enable treatment of cancers, which are presently not eligible for radiotherapy. [ 12,13 ] Tissue markers currently used in the clinic are metal-based solid implants with large physical dimensions, which require complicated insertion procedures and therefore the risk of complications. Lung tumor insertion is especially problematic, with pneumothorax (reported in 33%-68% of patients) as well as bleeding being reported as primary complications.…”

Section: Introductionmentioning

confidence: 99%

Injectable Colloidal Gold for Use in Intrafractional 2D Image‐Guided Radiation Therapy

Jølck

Rydhög

Christensen

et al. 2015

Adv Healthcare Materials

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In the western world, approximately 50% of all cancer patients receive radiotherapy alone or in combination with surgery or chemotherapy. Image-guided radiotherapy (IGRT) has in recent years been introduced to enhance precision of the delivery of radiation dose to tumor tissue. Fiducial markers are often inserted inside the tumor to improve IGRT precision and to enable monitoring of the tumor position during radiation therapy. In the present article, a liquid fi ducial tissue marker is presented, which can be injected into tumor tissue using thin and fl exible needles. The liquid fi ducial has high radioopacity, which allows for marker-based image guidance in 2D and 3D X-ray imaging during radiation therapy. This is achieved by surface-engineering gold nanoparticles to be highly compatible with a carbohydrate-based gelation matrix. The new fi ducial marker is investigated in mice where they are highly biocompatible and stable after implantation. To investigate the clinical potential, a study is conducted in a canine cancer patient with spontaneous developed solid tumor in which the marker is successfully injected and used to align and image-guide radiation treatment of the canine patient. It is concluded that the new fi ducial marker has highly interesting properties that warrant investigations in cancer patients.

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“…It is essential to account for these motion deviations to achieve desired dose coverage of the target volumes and minimize normal tissue toxicities. Correcting for target motion and location can allow the oncologist to prescribe tighter treatment margins around the tumor, possibly reducing the dose to normal tissue 5 , 7 …”

Section: Introductionmentioning

confidence: 99%

“…Many of these IGRT methods rely on comparing daily X‐ray images taken at the time of treatment to images created at the time of treatment planning. The target geometric deviation is then determined by aligning the soft tissue structures, bony anatomy, (11) implanted fiducial markers, 4 , 7 or other landmarks to the corresponding ones on the original images. When X‐ray‐based imaging is used for IGRT, it is typically at the discretion of the oncologist or radiation therapist to align the daily images with the original treatment planning images, sometimes with the help of computer‐assisted registration software (10) .…”

Section: Introductionmentioning

confidence: 99%

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Determination of optimal fiducial marker across image‐guided radiation therapy (IGRT) modalities: visibility and artifact analysis of gold, carbon, and polymer fiducial markers

Handsfield¹,

Yue²,

Zhou³

et al. 2012

J Applied Clin Med Phys

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The purpose of this study was to evaluate the visibility and artifact created by gold, carbon, and polymer fiducial markers in a simple phantom across computed tomography (CT), kilovoltage (kV), and megavoltage (MV) linear accelerator imaging and MV tomotherapy imaging. Three types of fiducial markers (gold, carbon, and polymer) were investigated for their visibility and artifacts in images acquired with various modalities and with different imaging parameters (kV, mAs, slice thickness). The imaging modalities include kV CT, 2D linac‐based kilovoltage and megavoltage X‐ray imaging systems, kV cone‐beam CT, and normal and fine tomotherapy imaging. The images were acquired on a phantom constructed using Superflab bolus in which markers of each type were inserted into the center layer. The visibility and artifacts produced by each marker were assessed qualitatively and quantitatively. All tested markers could be identified clearly on the acquired CT and linac‐based kV images; gold markers demonstrated the highest contrast. On the CT images, gold markers produced a significant artifact, while no artifacts were observed with polymer markers. Only gold markers were visible when using linac‐based MV and tomotherapy imaging. For linac‐based kV images, the contrast increased with kV and mAs values for all the markers, with the gold being the most pronounced. On CT images, the contrast increased with kV for the gold markers, while decreasing for the polymer and carbon marker. With the bolus phantom used, we found that when kV imaging‐based treatment verification equipment is available, polymer and carbon markers may be the preferred choice for target localization and patient treatment positioning verification due to less image artifacts. If MV imaging will be the sole modality for positioning verification, it may be necessary to use gold markers despite the artifacts they create on the simulation CT images.PACS number: 87

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Dosimetric Impact and Theoretical Clinical Benefits of Fiducial Markers for Dose Escalated Prostate Cancer Radiation Treatment

Cited by 28 publications

References 43 publications

Improvement in Interobserver Accuracy in Delineation of the Lumpectomy Cavity Using Fiducial Markers

Improvement in Interobserver Accuracy in Delineation of the Lumpectomy Cavity Using Fiducial Markers

Injectable Colloidal Gold for Use in Intrafractional 2D Image‐Guided Radiation Therapy

Determination of optimal fiducial marker across image‐guided radiation therapy (IGRT) modalities: visibility and artifact analysis of gold, carbon, and polymer fiducial markers

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