Dosimetric properties of megavoltage grid therapy

Reiff, Jay E.; Huq, M. Saiful; Mohiuddin, Mohammed; Suntharalingam, N.

doi:10.1016/0360-3016(95)00114-3

Cited by 46 publications

(50 citation statements)

References 8 publications

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“…Whereas the low-dose bystander effect in a biological system is of relevance to carcinogenesis and could have serious implications for radiation risk assessment, the bystander signaling induced by a high dose has therapeutic implications. High-dose RIBEs could be the underlying mechanism involved in a novel treatment modality, such as high-dose spatially fractionated radiation GRID therapy for management of advanced cancers (33)(34)(35)(36)(37). Significant induction of LDL-enriched ceramide, secretory SMase, and TNF-a in serum from patients treated with spatially fractionated Figure 5.…”

Section: Discussionmentioning

confidence: 99%

Role of Tumor Necrosis Factor-α and TRAIL in High-Dose Radiation–Induced Bystander Signaling in Lung Adenocarcinoma

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Role of Tumor Necrosis Factor-α and TRAIL in High-Dose Radiation–Induced Bystander Signaling in Lung Adenocarcinoma

et al. 2007

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“…The dose distributions of grid block with hole diameters of 0.5 cm, 0.75 cm, 1.0 cm, 1.25 cm, and 1.5 cm with constant center‐to‐center spacing of 1.8 cm, were calculated separately using the Monte Carlo simulation technique. Since the prescription dose of 15 Gy per fraction in megavoltage grid therapy is widely accepted, 9 , 10 , 19 , 29 this dose was considered in comparison of the TR values for different grid blocks. Equivalent uniform dose (EUD) for a grid with hole diameter of 1.0 cm and center‐to‐center distance of 1.8 cm was calculated.…”

Section: Methodsmentioning

confidence: 99%

Is grid therapy useful for all tumors and every grid block design?

Gholami

Nedaie

Longo

et al. 2016

J Applied Clin Med Phys

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Grid therapy is a treatment technique that has been introduced for patients with advanced bulky tumors. The purpose of this study is to investigate the effect of the radiation sensitivity of the tumors and the design of the grid blocks on the clinical response of grid therapy. The Monte Carlo simulation technique is used to determine the dose distribution through a grid block that was used for a Varian 2100C linear accelerator. From the simulated dose profiles, the therapeutic ratio (TR) and the equivalent uniform dose (EUD) for different types of tumors with respect to their radiation sensitivities were calculated. These calculations were performed using the linear quadratic (LQ) and the Hug‐Kellerer (H‐K) models. The results of these calculations have been validated by comparison with the clinical responses of 232 patients from different publications, who were treated with grid therapy. These published results for different tumor types were used to examine the correlation between tumor radiosensitivity and the clinical response of grid therapy. Moreover, the influence of grid design on their clinical responses was investigated by using Monte Carlo simulations of grid blocks with different hole diameters and different center‐to‐center spacing. The results of the theoretical models and clinical data indicated higher clinical responses for the grid therapy on the patients with more radioresistant tumors. The differences between TR values for radioresistant cells and radiosensitive cells at 20 Gy and 10 Gy doses were up to 50% and 30%, respectively. Interestingly, the differences between the TR values with LQ model and H‐K model were less than 4%. Moreover, the results from the Monte Carlo studies showed that grid blocks with a hole diameters of 1.0 cm and 1.25 cm may lead to about 19% higher TR relative to the grids with hole diameters smaller than 1.0 cm or larger than 1.25 cm (with 95% confidence interval). In summary, the results of this study indicate that grid therapy is more effective for tumors with radioresistant characteristics than radiosensitive tumors.PACS number(s): 87.55.‐x

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“…Spatially fractionated radiotherapy (GRID) is a technique of irradiation that has been used successfully for the curative or palliative treatment of bulky tumors $6 cm (3)(4)(5). Irradiation is delivered through a specially made grid collimator or by using a multileaf collimator (MLC) as a grid field shaper (3,(6)(7)(8). In GRID therapy the target volume does not receive a homogeneous dose of radiation.…”

Section: Introductionmentioning

confidence: 99%