Dosimetry and Measured Differential W Values of Air for Heavy Ions

Kanai, Tatsuaki; Kohno, Toshiyuki; Minohara, Shinichi; Sudou, Michio; Takada, E.; Soga, F.; Kawachi, Kiyomitsu; Fukumura, Akifumi

doi:10.2307/3578867

Cited by 56 publications

(23 citation statements)

References 16 publications

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“…The heavy ion irradiation (Riken Ring Cyclotron, Wako-shi, Saitama, Japan) was performed at three different LET (22, 120 and 250 keV/µm for C ions and 67, 120 and 310 keV/µm for Ne ions) by decreasing the initial accelerated energy (135 MeV/µm) with the use of Lucite absorbers. Dosimetry has been described (Kanai et al, 1993. The cells were irradiated as a suspension in culture medium and this is the only departure from the previous irradiation in which the cells were attached to the inside wall of the flask.…”

Section: Methodsmentioning

confidence: 99%

Complex hprt deletion events are recovered after exposure of human lymphoblastoid cells to high-LET carbon and neon ion beams

Kagawa

Shimazu²,

Gordon³

et al. 1999

Mutagenesis

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Hypoxanthine phosphoribosyltransferase gene (hprt) mutations were induced in human TK-6 lymphoblastoid cells by irradiation at a linear energy transfer (LET) of 250 or 310 keV/µm for carbon and neon ions, respectively. At such a high level of LET, ions will lose most of their total energy and stop shortly after passing through the cell. The hprt mutations were analyzed by multiplex PCR, long-PCR and DNA sequencing of both genomic and cDNA. Over half of the C ion-induced hprt mutations (10 of 19) were point mutations, in contrast to 15% of the mutations induced by Ne ions (three of 20). The remaining 47 and 85% of the C and Ne ion-induced mutants, respectively, are deletion events. The latter events include three complex losses of multiple non-contiguous exon regions in both ion irradiation collections. We note that mutations involving the exon 6 region are frequent in the Ne ion collection: all three of the complex events retained the exon 6 region with flanking deletion of sequence and three other mutants involved deletion of this region. It may be concluded that these high-LET C and Ne ion irradiations produce different mutational spectra.

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Section: Methodsmentioning

confidence: 99%

Complex hprt deletion events are recovered after exposure of human lymphoblastoid cells to high-LET carbon and neon ion beams

Kagawa

Shimazu²,

Gordon³

et al. 1999

Mutagenesis

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“…The beam loses kinetic energy as it passes through the aluminum disk. Figure 4 shows the LET of carbon ions (Kanai et al 1993). The horizontal axis indicates the water equivalent thickness at which carbon ions penetrate, and the vertical axis indicates the LET of the carbon ions.…”

Section: Automatic Irradiation Systemmentioning

confidence: 99%

Heavy-ion beam irradiation facility for biological samples in RIKEN

Ryuto

Fukunishi

Hayashi

et al. 2008

Plant Biotechnology

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“…On the other side, this figure makes also apparent the well-known d isadvantage of carbon ions, namely the eno rmous amount of energy of carbon ions in order to reach an acceptable dose distribution in the domain of the target, where a SOBP is required. W ith the help of GEA NT4 a real depth dose curve (HIMAC, 290 MeV/nucleon [14][15]) has been determined. The role of GEA NT4 was only to account for the nuclear reactions, which are based in this Monte-Carlo code on an evaporation model.…”

Section: Resultsmentioning

confidence: 99%

“…Th is is, however, not satisfactory, since electron capture is a dynamical p rocess. Therefore the range of charged particles has been subjected to many studies due to the increasing importance of carbon ions in rad iotherapy [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The Role of Electron Capture and Energy Exchange of Positively Charged Particles Passing Through Matter

Ulmer¹

2012

JNPP

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The conventional treatment of the Bethe-Bloch equation for protons accounts for electron capture at the end of the projectile track by the small Barkas correction. This is only a possible way for protons, whereas for light and heavier charged nuclei the exchange of energy and charge along the track has to be accounted for by regarding the projectile charge q as a function of the residual energy. This leads to a significant modification of the Bethe-Bloch equation, otherwise the range in a mediu m is incorrectly determined. The linear energy transfer (LET) in the Bragg peak domain and at the distal end is significantly influenced by the electron capture: Thus the stepwise filling operation of the electron shells along the particle track is treated by the Fermi energy E F of Fermi-Dirac statistics and leads to the conversion of carbon ions from C 6+ at the beginning of the track to C 1+ at the Bragg peak reg ion. A rather significant consequence is that in the do main of the Bragg peak the superiority of carbon ions is reduced compared to protons.

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Dosimetry and Measured Differential W Values of Air for Heavy Ions

Cited by 56 publications

References 16 publications

Complex hprt deletion events are recovered after exposure of human lymphoblastoid cells to high-LET carbon and neon ion beams

Complex hprt deletion events are recovered after exposure of human lymphoblastoid cells to high-LET carbon and neon ion beams

Heavy-ion beam irradiation facility for biological samples in RIKEN

The Role of Electron Capture and Energy Exchange of Positively Charged Particles Passing Through Matter

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