Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

Farahani, Saeid; Alam, Nader Riahi; Haghgoo, Soheila; Khoobi, Mehdi; Geraily, Gh; Gorji, E

doi:10.31661/jbpe.v0i0.827

Cited by 5 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of this increment is that, when the polymer gel is irradiated, more energy will be deposited due to higher generations of photoelectrons resulted from the presence of ZnO NPs in the polymer gel which may lead to an increase in gel sensitivity. The sensitivity enhancement in the polymer gel dosimeter is essential to reduce a certain amount of absorbed dose to the patient while also being able to reduce random errors in radiotherapy treatment (11) . These results are in good agreement with those reported by Mustaqim et al, (26) and Banaee et al, (27) which showed that when the ZnO was added into the polymer gel formulation, the polymer gel's sensitivity increased.…”

Section: Discussionmentioning

confidence: 99%

“…There are a number of published studies on the significance and influence of nanoparticles on dose amplification in polymer gel dosimeter application (7)(8)(9)(10) . The fact that photoelectric chance increases when metal is presence inside a biological target leads to an increased dose absorption has driven the nanoparticle application in radiotherapy (radionanotherapy) (11) . This process takes advantage of the high mass-energy absorption coefficient (μen/ρ) of these materials relative to tissue.…”

Section: Introductionmentioning

confidence: 99%

“…As the deposited dose from ionizing radiation is proportionate to attenuation coefficient, the nanoparticles are high likely to increase the local tumor dose (12) . Despite that, with regard from extensive studies comprising radiation dose enhancement using gold nanoparticles, bismuth, and platinum in polymer gel dosimeter (7)(8)(9)(10)(11)(12) , several studies have been conducted to investigate the probable dominance of other high atomic numbers, Z nanoparticles mainly the metal oxide particles. Thus, the comparative valuation of the outcomes of dose enhancement in clinical radiotherapy has been scarce.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radiological properties and structural morphology of different MAGAT gel dosimeters formulation

Al-Asady

Razak²,

Zin³

et al. 2022

Int J Radiat Res

View full text Add to dashboard Cite

Background: : One of the most important qualities of a radiation dosimeter is tissueequivalent, which represents radiation absorption and scattering that is similar to that of human tissue. The goal of this study is to determine the radiological and structural properties of several MAGAT gel dosimeter formulations prior to irradiation. This will provide a basis on how radiation properties altered prior to irradiation, which will later affect radiation absorption behaviour. Materials and Methods: Radiological properties of different MAGAT gel formulations (MAGAT, MAGAT doped methylene blue, MAGAT doped zinc oxide nanoparticles, MAGAT dope methylene blue and zinc oxide nanoparticles) were measured from density, linear attenuation coefficients, mass attenuation coefficients and CT values. The results were compared to soft tissue and water as references. The gel's morphological structures were investigated using electron microscopy for better understanding of gel's absorption mechanism. Results: The mass density of all MAGAT gel formulations differed by up to 2.5% from that of water and are very close to that of muscle tissue. This is due to the high gelatin and monomer concentration used in MAGAT gel formulation. The CT-values, furthermore, are within the soft tissue range. The MAGAT doped with methylene blue and ZnO NPs demonstrated the greatest increase in linear attenuation value, as well as having a nano spider-web morphological structure with a large surface area, which may have increased gel sensitivity and attenuation coefficients of MAGAT gel. Conclusion: Different MAGAT gel formulations were found to exhibit similar radiological properties to soft tissues and water.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radiological properties and structural morphology of different MAGAT gel dosimeters formulation

Al-Asady

Razak²,

Zin³

et al. 2022

Int J Radiat Res

View full text Add to dashboard Cite

show abstract

“…Recently, addition of high atomic elements (such as bismuth, gadolinium, silver or gold nanoparticles, etc.) has been investigated for increasing photon sensitivity [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ].…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

“…Various studies have analyzed the MRI response of polymer gels for possible application in radiotherapy dose mapping ([ 58 , 63 ] and references therein). In particular, polymer gels have been investigated for dosimetry in conformal therapy, IMRT, IMAT, IGRT, VMAT and tomotherapy [ 55 , 70 , 83 , 88 , 102 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], small photon fields [ 136 , 137 , 138 ], stereotactic radiosurgery [ 55 , 139 , 140 , 141 , 142 ], 60-cobalt source [ 143 , 144 ], brachytherapy [ 55 , 85 , 92 , 145 , ...…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

View full text Add to dashboard Cite

Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

show abstract

Pilot Study of Polymerization Dynamics in nMAG Dose Gel

Merkis

Urbonavičius

Adlienė

et al. 2022

Gels

View full text Add to dashboard Cite

The essential component of modern radiation therapy is the application of steep dose gradients during patient treatment in order to maximize the radiation dose to the target volume and protect neighboring heathy tissues. However, volumetric dose distribution in an irradiated target is still a bottleneck of dose verification in modern radiotherapy. Dose gels are almost the only known dosimetry tool which allows for the evaluation of dose distribution in the irradiated volume due to gel’s polymerization upon irradiation. The accuracy of dose gel dosimetry has its own obstacle, which is related to the continuation of the gel’s polymerization after the radiation treatment procedure is finished. In this article, a method to monitor the polymerization dynamics of dose gels in real-time is proposed using a modified optical spectrometry system. Using the proposed method, the changes of the optical characteristics of irradiated nMAG dose gels in situ were assessed. The investigation revealed that the detectable polymerization in dose gel proceeds up to 6 h after irradiation. This time is significantly shorter compared with a commonly recommended 24 h waiting time allocated for polymer gel to settle. It was also found that dose rate significantly influences the temporal response of the nMAG dosimeter. By increasing the irradiation dose rate by a factor of 2, the time needed for the polymerization process to settle was increased by 22%. Identification of the gel’s post-irradiation polymerization time interval and its dependence on irradiation parameters will contribute to more accurate dose verification using dose gel dosimetry.

show abstract

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

Cited by 5 publications

References 51 publications

Radiological properties and structural morphology of different MAGAT gel dosimeters formulation

Radiological properties and structural morphology of different MAGAT gel dosimeters formulation

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Pilot Study of Polymerization Dynamics in nMAG Dose Gel

Contact Info

Product

Resources

About