Dosimetry of tumor targeting imaging by convergent X-ray beam as compared with nuclear medicine

Figueroa, R.; Guarda, Jaime; Leiva, Jorge Andres; Malano, Francisco; Valente, M.

doi:10.1016/j.apradiso.2020.109451

Cited by 1 publication

(4 citation statements)

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“…The scope of the OXIRIS project, as reported in this work, is to overcome such limitations attaining SNR improvements when targeting tumors by GNP fluorescence implementing a convergent X-ray beam coupled to a confocal EDXRF detection system with the remarkable advantage of mapping by exciting the K-lines of the high atomic number elements, like gold nanoparticles. Previous works [49][50][51] have demonstrated the feasibility of the technique here proposed. Furthermore, aimed at validating the methodology along with prototype design, dedicated Monte Carlo simulation tools 52,53 have been developed and implemented.…”

Section: Introductionmentioning

confidence: 77%

“…The effective distance from the X-ray source to F I G U R E 2 Dynamic (left) and static (right) configurations for orthovoltage X-ray convergent beam devices. 51 C-arc support for rotation (1), the X-ray tube (2), counterweight (3), dynamic convergent cone (4), dynamic focus (5), cathode electron gun (6), cylindrical anode and shield (7), collimator outlet holes (8), brake and shield (9), and static device focus (10) [Colour figure can be viewed at wileyonlinelibrary.com] the system geometrical focus is 150 mm. Finally, a hollow confocal spherical phantom was considered, made of ABS material, 0.8 mm thick and 10 cm in diameter, filled with water.…”

Section: Methodology and Prototype Designmentioning

confidence: 99%

“…Dynamic (left) and static (right) configurations for orthovoltage X‐ray convergent beam devices 51 . C‐arc support for rotation (1), the X‐ray tube (2), counterweight (3), dynamic convergent cone (4), dynamic focus (5), cathode electron gun (6), cylindrical anode and shield (7), collimator outlet holes (8), brake and shield (9), and static device focus (10) [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Methodsmentioning

confidence: 99%

“…F I G U R E 5 Orthovoltage X-Ray-Induced Radiation System (OXIRIS) prototype the different components are shown: The dynamic X-ray source mounted the different components are shown on the C-arm, the sample holder mounted on the automatic scanning system, the confocal detection system provided with precision positioners, and the phantom (white walls sphere) containing a gold nanoparticle (GNP)-infused artificial tumor; the while device is mounted on the metrology table 51 Figure 8 shows a typical XRF profile for the 1% w/w GNP concentration reporting acquired data along with corresponding smoothing and background.…”

Section: Oxiris Performance and Uncertaintiesmentioning

confidence: 99%

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OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

et al. 2021

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A novel and suitable energy‐dispersive X‐ray fluorescent (EDXRF) device, currently at the prototype stage, the Project OXIRIS (Orthovoltage X‐Ray–Induced Radiation System), is presented for the simultaneous detection and treatment of cancer diseases. Monte Carlo simulation and experimental results of EDXRF signals from a small deep artificial tumor consisting of a solution of gold nanoparticles bio‐targeted and immersed in a tissue‐bioequivalent matrix are presented and compared. Briefly, the device consists of a dynamic orthovoltage X‐ray fluence concentration coupled to confocal with an EDXRF system along with a sample holder for 3D scanning; all integrated and controlled by a dedicated software capable of controlling the whole operation functionalities: the X‐ray source, the rotating arm, the sample holder, and the detection system. The software also includes dedicated subroutines for X‐ray fluorescent spectra processing to correlate K‐lines signal at each acquisition position with the corresponding high atomic number elements' concentration to produce a 3D distribution according to the user‐defined grid. The confocal configuration ensures that the detected signal comes exclusively from the excited volume as defined by the bulk of the focal spot. Hence, the 3D image is achieved by scanning the sample holder through the movement of the sample‐carrier stretcher moved by step motors in the 3 coordinated axes. The feasibility of the proposed methodology and the design of the prototype have been successfully demonstrated experimentally, targeting gold nanoparticles in water‐equivalent phantoms.

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