Dosing, efficacy and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines

Lowe, Nicholas J.; Shah, Aadarsh; Lowe, Philippa; Patnaik, Rickie

doi:10.3109/14764170903480013

Cited by 31 publications

(20 citation statements)

References 13 publications

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“…In another study, ONA (256 U total) was significantly more effective than ABO (64 U total) (dose ratio of 4:1) for upper face lines. However, an objective measurement by computerized photographic numerical assessment showed greater efficacy in the crow’s feet region with ABO vs ONA when a 3:1 dose ratio (96 U:32 U) was used [17]. …”

Section: Discussionmentioning

confidence: 99%

“…At doses of 20 and 30 U ABO for the unilateral glabellar and unilateral crow’s feet regions, respectively, onset of action based on patient self-assessment was shown to be significantly quicker than with ONA at 8 U in the unilateral glabellar and 10 U in the crow’s feet regions. Other studies compared the efficacies of ABO and ONA in different patients and thus do not account for variations between individuals, such as muscle mass and severity of wrinkles [17]. The current study was an internally controlled, prospective study with blinding of the patients as well as the evaluators and thus established better measures to compare clinical efficacy (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Triple-Blind, Prospective, Internally Controlled Comparative Study Between AbobotulinumtoxinA and OnabotulinumtoxinA for the Treatment of Facial Rhytids

Kassir

Kolluru

Kassir³

2013

Dermatol Ther (Heidelb)

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IntroductionOnabotulinumtoxinA (ONA; Botox, Allergan, Irvine, CA) was discovered for cosmetic use in the mid-1980s for which it was FDA approved in April 2002. AbobotulinumtoxinA (ABO; Dysport, Valeant Pharmaceuticals International, Inc, Montreal, Quebec) was FDA approved in April 2009 for therapeutic and esthetic uses. The most recent studies make a comparison between the two formulations; however, information is still lacking in comparison studies. In this study, we compare efficacy and safety of a single treatment of two preparations of botulinum toxin A in patients with moderate to severe rhytids in the glabellar and crow’s feet areas.MethodsA total of 85 patients with moderate to severe wrinkles in either the glabellar or crow’s feet area, or both, were given a single injection on day 0, with ABO and ONA injected on opposite sides of the face. Follow-up assessments were done at 2 weeks, 1 month, 3 months, 4 months, and 5 months. The study end points were onset of action, change in degree of wrinkles, patient satisfaction, duration of effect, and adverse effects.ResultsResults of onset of improvement with ABO vs. ONA in the glabellar and crow’s feet regions show higher percentage of patients with earlier onset improvement with ABO. Evaluator assessment showed ABO lasted longer after 3 months in a significant number of patients in both areas, 83% with ABO vs. 48% with ONA at 4 months in the glabellar area, and 65% with ABO vs. 47% with ONA at 4 months in the crow’s feet area.ConclusionTime to improvement showed earlier onset and longer duration of improvement in a higher percentage of individuals with ABO when compared with ONA. ABO provides a safe and effective alternative in a dose ratio of 2.5:1 and 3:1 in the glabellar and crow’s feet area, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Triple-Blind, Prospective, Internally Controlled Comparative Study Between AbobotulinumtoxinA and OnabotulinumtoxinA for the Treatment of Facial Rhytids

Kassir

Kolluru

Kassir³

2013

Dermatol Ther (Heidelb)

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“…Some studies have attempted to compare the efficacy and the duration of action of the different products among each other. The results remain controversial, so that currently no clear evaluation can be made .…”

Section: A: General Commentsmentioning

confidence: 99%

S1 guideline aesthetic botulinum toxin therapy

Imhof

Sommer²

2013

J Deutsche Derma Gesell

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“…Results from quantitative studies show that the onset and duration of benefit is variable when different BTXs are compared [20]. This is not surprising, as different BTXs are individual molecules with different molecular weights.…”

Section: Recent Quantitative Studies Of Btx-a For Facial Linesmentioning

confidence: 99%

Botulinum Toxins for Facial Lines: A Concise Review

Lowe

2012

Dermatol Ther (Heidelb)

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This is a concise review of the uses of botulinum toxins (BTXs) in dermatology and cosmetic procedures. It is a clinical rather than a basic science, pharmacological review. BTX had been initially used for selectively reducing and balancing periorbital muscle activity; thereby, reducing childhood strabismus and blepharospasm. This clinical research was initiated by Dr. Alan Scott over 40 years ago. BTX type A (BTX-A) was serendipitously observed to reduce forehead frown lines in patients being treated for blepharospasm. Extensive clinical research and development resulted in widespread aesthetic uses for BTX-A by reduction of selected hyperfunctional facial muscles. BTXs are also used for reduced localized hyperhidrosis. A topical BTX-A is being developed as a potential alternative to injected BTX.

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Dosing, efficacy and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines

Abstract: Two different botulinum toxins type A were shown to be effective and safe for hyperfunctional facial lines. The choice of dose, dilution and placement is critical for each individual toxin. Computerized photography gave numerical severity scores of crow's feet severity.

Cited by 31 publications

References 13 publications

Triple-Blind, Prospective, Internally Controlled Comparative Study Between AbobotulinumtoxinA and OnabotulinumtoxinA for the Treatment of Facial Rhytids

Triple-Blind, Prospective, Internally Controlled Comparative Study Between AbobotulinumtoxinA and OnabotulinumtoxinA for the Treatment of Facial Rhytids

S1 guideline aesthetic botulinum toxin therapy

Botulinum Toxins for Facial Lines: A Concise Review

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