Dosing Frequency and Medication Adherence in Chronic Disease

Coleman, Craig I.; Limone, Brendan; Sobieraj, Diana M; Lee, Soyon; Roberts, Matthew; Kaur, Rajbir; Alam, Tawfikul

doi:10.18553/jmcp.2012.18.7.527

Cited by 360 publications

(309 citation statements)

References 61 publications

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“…In other study this information confirmed that lower adherence was associated with more prescribed medications [10], especially in users of diuretics and beta blockers, rarely in users of angiotensin -converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) [11], which was promoted by…”

Section: Discussionmentioning

confidence: 55%

The causes of low adherence in patients with antihypertensive therapy

et al. 2016

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Abstract. Low adherence to antihypertensive therapy is a major cause of adverse cardiovascular outcomes by uncontrolled high blood pressure. If the most frequent causes of inappropriate taking of medicine are identified, possible improvements within the health care could be performed, promoting the safety and efficacy of antihypertensive therapy. The aim was to find the factors affecting patient's adherence during antihypertensive therapy. In the period from June to September 2014 a quantitative study was carried out including patients with diagnosed arterial hypertension who visited pharmacies in Riga to get the antihypertensive therapy. The study collected data of 152 patients with the mean antihypertensive treatment duration of 9.7 ± 2.4 years. Most of the patients knew the reason for the use of the medication (n = 123, 80.8%), but it was also unclear for some patients (n = 29, 19.2%), more frequently with use of 2 or 3 medications at the same time, compared with the patients who received 4 or more medications (n = 26, 17.3% vs n = 3, 1.9%; p = 0.063). High medication load was more frequently associated with lower adherence during antihypertensive therapy. Awareness of antihypertensive therapy for an individual patient, reminders of prescribed medications and dosage instructions may contribute to adherence of patients.

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Section: Discussionmentioning

confidence: 55%

The causes of low adherence in patients with antihypertensive therapy

et al. 2016

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“…A switch from a daily to a twice daily regimen was considered acceptable (i.e., a therapeutic alternative), but conversion to a 3 or more times a day drug was not considered acceptable due to the increased risk of nonadherence. [17][18][19] 4. For medications still remaining, the reviewer determined if the medication was a branded member of a class that is thought clinically to have class effect benefits and minimal risk of harm in switching (i.e., a therapeutic alternative).…”

Section: ■■ Methodsmentioning

confidence: 99%

A Case Study in Generic Drug Use: Should There Be Risk Adjustment in Incentive Payments for the Use of Generic Medications?

Walton¹,

Rash

Lambert³

et al. 2014

JMCP

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BACKGROUND: Encouraging generic drug use has reduced health care costs for payers and consumers, but the availability of therapeutically interchangeable medications or generic medications of choice is not equal across disease states. The extent to which systems of care are able to substitute with generics is not well understood. OBJECTIVES: To (a) define and measure the maximum generic rate (MGR) of currently prescribed drugs within an academic medical group in and (b) illustrate differences across drugs associated with selected underlying diseases. METHODS: Prescription claims data were examined from an academic medical group in Chicago, Illinois. Based on pharmacologic and therapeutic criteria, drugs were classified into 2 categories-potentially substitutable and not potentially substitutable-based on whether the drugs are branded forms of the same chemical entities that are available as generics or are therapeutically interchangeable with other medications that have different chemical compositions but the same mechanisms of action and potential efficacy. A medication was considered potentially substitutable if it (a) did not have a narrow therapeutic index as defined by the FDA; (b) did not belong to 1 of 6 protected classes of drugs in the Medicare D provisions; (c) was substitutable with a generic medication containing the same chemical entity; or (d) was therapeutically interchangeable with a therapeutically equivalent medication. MGR was defined as the percentage of prescriptions that could potentially be prescribed in generic form. This rate was examined overall and across drugs known to be associated with illustrative diseases including hypertension, diabetes mellitus, and obstructive lung diseases. RESULTS: The MGR ranged from 100% for drugs used in hypertension to 26.7% for drugs used in obstructive lung diseases. The MGR was 83.6%. CONCLUSIONS: Payers wishing to promote generic substitution should incorporate the potential for substitution of clinically appropriate generic medications as part of incentives for generic utilization to avoid unintended consequences of using a fixed target rate. A practical methodology for determining an MGR is offered.

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“…Studies have demonstrated an inverse relationship between medication adherence and dosing frequency in patients with chronic diseases. Up to a 19% decrease in taking adherence, up to a 23% decrease in regimen adherence, and up to a 54% decrease in timing adherence in chronically ill patients whose treatment required them to take multiple daily doses compared to patients who are on once-daily regimens [62]. Similarly, researchers found that adherence was up to 12% higher in patients on a once-weekly dosing regimen compared to patients on more frequently dosed agents for the same conditions and up to 96% of patients preferred an intermittent dosing regimen [63].…”

Section: Igg-fc Fusion Therapeutics In a Real World Settingmentioning

confidence: 99%