DOTAP Modified Formulations of Aminoacid Based Cationic Liposomes for Improved Gene Delivery and Cell Viability
Venkatesh Ravula,
Venkanna Muripiti,
Akash Kumar
et al.
Abstract:The liposomal systems proved remarkably useful for the delivery of genetic materials but enhancing their efficacy remains a significant challenge. While structural alterations could result in the discovery of more effective transfecting lipids, improving the efficacy of widely used lipid carriers is also crucial in order to compete with viral vectors for gene delivery. Herein, we developed formulations of commercially available lipid, 1,2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP) with synthetic cationic lip… Show more
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