Double-blind evaluation of nebulized cromolyn, terbutaline, and the combination for childhood asthma

Gg, Shapiro; Ct, Furukawa; We, Pierson; Sharpe, Melissa J; Menendez, Rogelio; Cw, Bierman

doi:10.1016/0091-6749(88)90915-3

Cited by 27 publications

(6 citation statements)

References 5 publications

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“…alone or in combination with nebulized terbutaline (0.1 mg/kg t.d.s.) but not after treatment with terbutaline alone in 27 children aged 6-12 years [36], Peak fiow was significantly higher witb the combination than with either drug alone, and cough was significantly reduced during DSCG treatment compared to terbutaline therapy. The study suggested a better effect of DSCG than terbutaline in the control of childhood asthma [36].…”

Section: School Children and Adolescentsmentioning

confidence: 79%

“…Several studies have assessed the long-term effect of inhaled DSCG and inhaled glucocorticoids on bronchial hyper-responsiveness (BHR) in children. Eight weeks' DSCG freatment alone or in combination with terbutaline reduced metacholine reactivity in asthmatic children whereas terbutaline alone did not [36]. Watanabe reported reduced sensitivity to histamine in 34 children with mild asthma over a 3year period of freatment with inhaled DSCG 20 mg t.d.s.…”

Section: Eftect On Bronchial Responsivenessmentioning

confidence: 99%

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The efficacy of inhaled disodium cromoglycate and glucocorticoids

Larsson²

1996

Clin Experimental Allergy

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Section: School Children and Adolescentsmentioning

confidence: 79%

Section: Eftect On Bronchial Responsivenessmentioning

confidence: 99%

The efficacy of inhaled disodium cromoglycate and glucocorticoids

Larsson²

1996

Clin Experimental Allergy

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“…Shapiro et al. (5) compared nebulized SCG, terbutaline, and the combination of the two, in a double‐blind cross‐over study in 27 children with mild‐to‐moderate asthma. Significant differences between treatments were found in three out of 12 variables.…”

Section: Discussionmentioning

confidence: 99%

The combination of nebulized sodium cromoglycate and salbutamol in the treatment of moderate‐to‐severe asthma in children

Furusho¹,

Nishikawa²,

Sasaki³

et al. 2002

Pediatric Allergy Immunology

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The aim of this multi-centre prospective study was to evaluate the efficacy, tolerability, and safety of the combination of sodium cromoglycate (SCG) and salbutamol (administered as a nebulized solution), compared to SCG alone and salbutamol alone, in the management of severe, intractable asthma in childhood. The study was an open, randomized, cross-over trial of 12 weeks' duration in children with moderate-to-severe intractable asthma. All treatments were administered twice daily by powered nebulizer. The primary outcome measure was the change in asthma severity, as measured by the mean asthma score during the last 2 weeks of a baseline period and the last 2 weeks of each treatment. Secondary outcome measure was the patient's opinion of the effectiveness of treatment. The change in asthma scores from baseline values were significantly greater with the combination treatment compared to each component administered separately. The mean difference in asthma score between the combination and salbutamol was: -7.5; 95% CI, -11.70 to -3.29 (p < 0.0001). The mean difference between the combination and SCG was: -8.53; 95% CI, -14.03 to -3.25 (p < 0.0001). Patients were also significantly in favor of combination treatment (p < 0.001 vs. salbutamol; p < 0.01 vs. SCG). Two patients reported adverse effects. We concluded that regular twice-daily inhalation of a combination of SCG and salbutamol gave better control of symptoms than previous treatments in patients with severe, intractable asthma. Few adverse effects with this therapy suggest that it is extremely useful, safe, and effective.

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“…Shapiro et al [102] compared nebulized cromolyn. sodium, terbutaline or the combination in 27 children aged 6-12 years with mild to moderate perennial asthma.…”

Section: Nebulizer Solutionmentioning

confidence: 99%

Sodium cromoglycate (Intal®) as an anti‐inflammatory agent for the treatment of chronic asthma

Edwards¹

1994

Clin Experimental Allergy

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Double-blind evaluation of nebulized cromolyn, terbutaline, and the combination for childhood asthma

Cited by 27 publications

References 5 publications

The efficacy of inhaled disodium cromoglycate and glucocorticoids

The efficacy of inhaled disodium cromoglycate and glucocorticoids

The combination of nebulized sodium cromoglycate and salbutamol in the treatment of moderate‐to‐severe asthma in children

Sodium cromoglycate (Intal®) as an anti‐inflammatory agent for the treatment of chronic asthma

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