Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling

Kim, Suck Won; Grant, Jon E.; Adson, David E.; Shin, Young Chul

doi:10.1016/s0006-3223(01)01079-4

Cited by 454 publications

(265 citation statements)

References 32 publications

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“…Significant time effects were noted with respect to ASI-G scores and dollars wagered. Reductions in gambling with no or minimal interventions have also been reported in pharmacological (Kim, Grant, Adson, & Shin;Grant et al, 2006) and other psychosocial treatment studies of gamblers (Hodgins et al, 2001;Petry et al, 2006). Decreases in gambling are reflected in epidemiological research as well.…”

Section: Discussionmentioning

confidence: 78%

A randomized trial of brief interventions for problem and pathological gamblers.

Petry¹,

Weinstock²,

Ledgerwood³

et al. 2008

Journal of Consulting and Clinical Psychology

137

112

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Limited research exists regarding methods for reducing problem gambling. Problem gamblers (N=180) were randomly assigned to: assessment only control, 10 minutes of Brief Advice, 1 session of motivational enhancement therapy (MET), or 1 session of MET plus 3 sessions of cognitivebehavioral therapy (CBT). Gambling was assessed at baseline, 6 weeks later, and a 9-month followup. Relative to assessment only, Brief Advice was the only condition that significantly decreased gambling between baseline and week 6, and it was associated with clinically significant reductions in gambling at month 9. Between week 6 and month 9, MET+CBT evidenced significantly reduced gambling on one index compared to the control condition. These results suggest the efficacy of a very brief intervention for reducing gambling among problem and pathological gamblers not actively seeking gambling treatment.

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Section: Discussionmentioning

confidence: 78%

A randomized trial of brief interventions for problem and pathological gamblers.

Petry¹,

Weinstock²,

Ledgerwood³

et al. 2008

Journal of Consulting and Clinical Psychology

137

112

View full text Add to dashboard Cite

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“…In addition, PG has demonstrated responses to opioid antagonists [30,31], drugs that have not been shown to be effective in treating OCD. The response of PG to pharmacologic treatment has been studied insufficiently to determine clearly the choice of treatment.…”

Section: Treatment Of Pathological Gamblingmentioning

confidence: 99%

Compulsive Aspects of Impulse-Control Disorders

Grant

Potenza

2006

Psychiatric Clinics of North America

157

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“…At present, the neuropharmacological basis for this frontal dysfunction is unclear. A possible clue derives from the fact that opioid receptor antagonists exhibit some degree of efficacy across several disorders characterized by the loss of control over appetitively motivated behavior (Cambridge et al, 2013;Kim et al, 2001;Mitchell et al, 2007;Volpicelli et al, 1992). This observation could suggest a role for dysregulated opioid signaling, possibly in frontal cortex, in the etiology of inhibitory control deficits.…”

Section: Introductionmentioning

confidence: 99%

Endogenous Opioid Signaling in the Medial Prefrontal Cortex is Required for the Expression of Hunger-Induced Impulsive Action

Selleck

Lake

Estrada

et al. 2015

Neuropsychopharmacol

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Opioid transmission and dysregulated prefrontal cortex (PFC) activity have both been implicated in the inhibitory-control deficits associated with addiction and binge-type eating disorders. What remains unknown, however, is whether endogenous opioid transmission within the PFC modulates inhibitory control. Here, we compared intra-PFC opioid manipulations with a monoamine manipulation (d-amphetamine), in two sucrose-reinforced tasks: progressive ratio (PR), which assays the motivational value of an incentive, and differential reinforcement of low response rates (DRLs), a test of inhibitory control. Intra-PFC methylnaloxonium (M-NX, a limited diffusion opioid antagonist) was given to rats in a 'low-drive' condition (2-h food deprivation), and also after a motivational shift to a 'highdrive' condition (18-h food deprivation). Intra-PFC DAMGO (D-[Ala2,N-MePhe4, Gly-ol]-enkephalin; a μ-opioid agonist) and damphetamine were also tested in both tasks, under the low-drive condition. Intra-PFC M-NX nearly eliminated impulsive action in DRL engendered by hunger, at a dose (1 μg) that significantly affected neither hunger-induced PR enhancement nor hyperactivity. At a higher dose (3 μg), M-NX eliminated impulsive action and returned PR breakpoint to low-drive levels. Conversely, intra-PFC DAMGO engendered 'high-drive-like' effects: enhancement of PR and impairment of DRL performance. Intra-PFC d-amphetamine failed to produce effects in either task. These results establish that endogenous PFC opioid transmission is both necessary and sufficient for the expression of impulsive action in a high-arousal, high-drive appetitive state, and that PFC-based opioid systems enact functionally unique effects on food impulsivity and motivation relative to PFC-based monoamine systems. Opioid antagonists may represent effective treatments for a range of psychiatric disorders with impulsivity features.

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Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling

Cited by 454 publications

References 32 publications

A randomized trial of brief interventions for problem and pathological gamblers.

A randomized trial of brief interventions for problem and pathological gamblers.

Compulsive Aspects of Impulse-Control Disorders

Endogenous Opioid Signaling in the Medial Prefrontal Cortex is Required for the Expression of Hunger-Induced Impulsive Action

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